The synergetic effect of childhood trauma and recent stressful events in psychosis: associated neurocognitive dysfunction

Background A higher incidence of childhood trauma (CT) has been reported in first episode of psychosis (FEP). There is, however, a lack of knowledge about the synergetic effect between CT and recent stressful events (RSE). Methods Information on specific types of CT (under 17 years) and RSE (within...

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Authors: Ayesa Arriola, Rosa; Setien Suero, Esther; Marques-Feixa, Laia; Neergaard, Karl; Butjosa, A.; Vázquez-Bourgon, J.; Fañanás Saura, Lourdes; Crespo Facorro, Benedicto
Format: Article
Status:Accepted version
Publication date:2019
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/173141
Online Access:https://hdl.handle.net/2445/173141
Access Level:Open access
Keyword:Traumes psíquics
Malalties mentals
Infants
Psychic trauma
Mental illness
Children
Summary:Background A higher incidence of childhood trauma (CT) has been reported in first episode of psychosis (FEP). There is, however, a lack of knowledge about the synergetic effect between CT and recent stressful events (RSE). Methods Information on specific types of CT (under 17 years) and RSE (within the past 3 years) was available for 290 FEP patients and 52 healthy controls (HC). Cognitive function at baseline was assessed through a comprehensive neuropsychological test battery. Results While 45.2% of FEP patients and 25% of HC reported at least one CT event, 62.7% of FEP and 21.2% of HC reported an RSE. Meanwhile, 36.2% of FEP patients and 9.6% of HC encountered both childhood and recent stressful events. The patients that just reported CT showed normality in all but the verbal memory cognitive domain; those with additive CT and RSE presented worse general cognitive function, specifically on working memory, processing speed, and executive function. RSE and general cognitive dysfunction were significant determinants of psychosis onset. Conclusions These results support a synergetic influence of trauma and stressful events on brain function and allow a better understanding of mediators for psychotic disorders useful in the design of specific strategies based on stress‐targeted therapies.

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