Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated in the pathogenesis of various brain diseases, including neurodegenerative disorders, stroke, and psychiatric illnesses. T...
| Autores: | ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artigo |
| Data de publicação: | 2023 |
| País: | España |
| Recursos: | Universidad Europea (UEM) |
| Repositório: | ABACUS. Repositorio de Producción Científica |
| Idioma: | Inglês |
| OAI Identifier: | oai:abacus.universidadeuropea.com:11268/12344 |
| Acesso em linha: | http://hdl.handle.net/11268/12344 |
| Nível de acesso: | Acesso aberto |
| Palavra-chave: | Mitocondrias Enfermedades neurodegenerativas Análisis mutacional de ADN Enfermedad del sistema nervioso Investigación sobre el cerebro Genética humana |
| _version_ | 1878741642605756416 |
|---|---|
| author | Clemente Suárez, Vicente Javier |
| author2 | Redondo Flórez, Laura Beltrán Velasco, Ana Isabel Ramos Campo, Domingo Jesús Belinchón de Miguel, Pedro Martínez Guardado, Ismael Dalamitros, Athanasios A. Yáñez Sepúlveda, Rodrigo Martín Rodríguez, Alexandra Tornero Aguilera, José Francisco |
| author2_role | author author author author author author author author author |
| author_browse | Belinchón de Miguel, Pedro Beltrán Velasco, Ana Isabel Clemente Suárez, Vicente Javier Dalamitros, Athanasios A. Martín Rodríguez, Alexandra Martínez Guardado, Ismael Ramos Campo, Domingo Jesús Redondo Flórez, Laura Tornero Aguilera, José Francisco Yáñez Sepúlveda, Rodrigo |
| author_facet | Clemente Suárez, Vicente Javier Redondo Flórez, Laura Beltrán Velasco, Ana Isabel Ramos Campo, Domingo Jesús Belinchón de Miguel, Pedro Martínez Guardado, Ismael Dalamitros, Athanasios A. Yáñez Sepúlveda, Rodrigo Martín Rodríguez, Alexandra Tornero Aguilera, José Francisco |
| author_role | author |
| collection | ABACUS. Repositorio de Producción Científica |
| description | Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated in the pathogenesis of various brain diseases, including neurodegenerative disorders, stroke, and psychiatric illnesses. This review paper provides a comprehensive overview of the intricate relationship between mitochondria and brain disease, focusing on the underlying pathological mechanisms and exploring potential therapeutic opportunities. The review covers key topics such as mitochondrial DNA mutations, impaired oxidative phosphorylation, mitochondrial dynamics, calcium dysregulation, and reactive oxygen species generation in the context of brain disease. Additionally, it discusses emerging strategies targeting mitochondrial dysfunction, including mitochondrial protective agents, metabolic modulators, and gene therapy approaches. By critically analysing the existing literature and recent advancements, this review aims to enhance our understanding of the multifaceted role of mitochondria in brain disease and shed light on novel therapeutic interventions. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_e8d46a206675bc77ebcaa7584352bf72 |
| institution | Universidad Europea (UEM) |
| instname_str | Universidad Europea (UEM) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:abacus.universidadeuropea.com:11268/12344 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| reponame_str | ABACUS. Repositorio de Producción Científica |
| spelling | Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities Clemente Suárez, Vicente Javier Redondo Flórez, Laura Beltrán Velasco, Ana Isabel Ramos Campo, Domingo Jesús Belinchón de Miguel, Pedro Martínez Guardado, Ismael Dalamitros, Athanasios A. Yáñez Sepúlveda, Rodrigo Martín Rodríguez, Alexandra Tornero Aguilera, José Francisco Mitocondrias Enfermedades neurodegenerativas Análisis mutacional de ADN Enfermedad del sistema nervioso Investigación sobre el cerebro Genética humana Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated in the pathogenesis of various brain diseases, including neurodegenerative disorders, stroke, and psychiatric illnesses. This review paper provides a comprehensive overview of the intricate relationship between mitochondria and brain disease, focusing on the underlying pathological mechanisms and exploring potential therapeutic opportunities. The review covers key topics such as mitochondrial DNA mutations, impaired oxidative phosphorylation, mitochondrial dynamics, calcium dysregulation, and reactive oxygen species generation in the context of brain disease. Additionally, it discusses emerging strategies targeting mitochondrial dysfunction, including mitochondrial protective agents, metabolic modulators, and gene therapy approaches. By critically analysing the existing literature and recent advancements, this review aims to enhance our understanding of the multifaceted role of mitochondria in brain disease and shed light on novel therapeutic interventions. http://hdl.handle.net/11268/12344 |
| spellingShingle | Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities Clemente Suárez, Vicente Javier Mitocondrias Enfermedades neurodegenerativas Análisis mutacional de ADN Enfermedad del sistema nervioso Investigación sobre el cerebro Genética humana |
| title | Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities |
| title_full | Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities |
| title_fullStr | Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities |
| title_full_unstemmed | Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities |
| title_short | Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities |
| title_sort | Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities |
| topic | Mitocondrias Enfermedades neurodegenerativas Análisis mutacional de ADN Enfermedad del sistema nervioso Investigación sobre el cerebro Genética humana |
| topic_facet | Mitocondrias Enfermedades neurodegenerativas Análisis mutacional de ADN Enfermedad del sistema nervioso Investigación sobre el cerebro Genética humana |
| url | http://hdl.handle.net/11268/12344 |