Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer's Disease Pathology
GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer's disease (LOAD) with reported odds ratios (ORs) ranging from 0.75-0.85. We tested eight GAB2 variants in four North American Caucasian case-control series (2,316 LOAD, 2,538 contr...
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| Format: | Article |
| Publication date: | 2013 |
| Country: | España |
| Institution: | Universitat Autònoma de Barcelona |
| Repository: | Dipòsit Digital de Documents de la UAB |
| Language: | English |
| OAI Identifier: | oai:ddd.uab.cat:303536 |
| Online Access: | https://ddd.uab.cat/record/303536 https://dx.doi.org/urn:doi:10.1371/journal.pone.0064802 |
| Access Level: | Open access |
| _version_ | 1878741399486070784 |
|---|---|
| author | Zou, Fanggeng |
| author2 | Belbin, Olivia|||0000-0002-6109-6371 Carrasquillo, Minerva M. Culley, Oliver J. Hunter, Talisha A. Ma, Li Bisceglio, Gina D. Allen, Mariet Dickson, Dennis W.|||0000-0001-7189-7917 Graff-Radford, Neill R. Petersen, Ronald C. Morgan, Kevin|||0000-0002-8217-2396 Younkin, Steven G. Harold, Denise|||0000-0001-5195-0143 Sims, Rebecca C. Gerrish, Amy Chapman, Jade A. Moskvina, V. Abraham, Richard Hollingworth, Paul Hamshere, M. Singh Pahwa, J. Dowzell, K. Williams, A. Jones, Nicola Thomas, Charlene Stretton, A. Morgan, A. Williams, K. Lovestone, Simon|||0000-0003-0473-4565 Powell, J. Proitsi, P. Lupton, M.K. Brayne, C. Rubinsztein, D.C. Gill, M. Lawlor, B. Lynch, A. Brown, K. Passmore, P. Craig, D. McGuinness, B. Johnston, J.A. Todd, S. Holmes, Clive Mann, D. David Smith, A. Love, S. Kehoe, P.G. Hardy, J. Guerreiro, Rita|||0000-0001-5879-3486 Singleton, A. Mead, S. Fox, N. Rossor, M. N. Collinge, John Maier, Wolfgang Jessen, Frank Heun, R. Schürmann, B. Ramirez, Alfredo|||0000-0003-4991-763X Herold, C. Lacour, A. Drichel, D. van den Bussche, H. Heuser, I. Kornhuber, Johannes|||0000-0002-8096-3987 Wiltfang, J. Dichgans, Martin|||0000-0002-0654-387X Frölich, L. Hampel, H. Hüll, M. Rujescu, D. Goate, A. Kauwe, J.S.K. Cruchaga, Carlos|||0000-0002-0276-2899 Nowotny, P. Morris, J.C. Mayo, K. Livingston, G. Bass, N.J. Gurling, H. McQuillin, A. Gwilliam, R. Deloukas, P. Nöthen, M.M. Holmans, Peter|||0000-0003-0870-9412 O'Donovan, M. Owen, M.J. Williams, J. |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Abraham, Richard Allen, Mariet Bass, N.J. Belbin, Olivia|||0000-0002-6109-6371 Bisceglio, Gina D. Brayne, C. Brown, K. Carrasquillo, Minerva M. Chapman, Jade A. Collinge, John Craig, D. Cruchaga, Carlos|||0000-0002-0276-2899 Culley, Oliver J. David Smith, A. Deloukas, P. Dichgans, Martin|||0000-0002-0654-387X Dickson, Dennis W.|||0000-0001-7189-7917 Dowzell, K. Drichel, D. Fox, N. Frölich, L. Gerrish, Amy Gill, M. Goate, A. Graff-Radford, Neill R. Guerreiro, Rita|||0000-0001-5879-3486 Gurling, H. Gwilliam, R. Hampel, H. Hamshere, M. Hardy, J. Harold, Denise|||0000-0001-5195-0143 Herold, C. Heun, R. Heuser, I. Hollingworth, Paul Holmans, Peter|||0000-0003-0870-9412 Holmes, Clive Hunter, Talisha A. Hüll, M. Jessen, Frank Johnston, J.A. Jones, Nicola Kauwe, J.S.K. Kehoe, P.G. Kornhuber, Johannes|||0000-0002-8096-3987 Lacour, A. Lawlor, B. Livingston, G. Love, S. Lovestone, Simon|||0000-0003-0473-4565 Lupton, M.K. Lynch, A. Ma, Li Maier, Wolfgang Mann, D. Mayo, K. McGuinness, B. McQuillin, A. Mead, S. Morgan, A. Morgan, Kevin|||0000-0002-8217-2396 Morris, J.C. Moskvina, V. Nowotny, P. Nöthen, M.M. O'Donovan, M. Owen, M.J. Passmore, P. Petersen, Ronald C. Powell, J. Proitsi, P. Ramirez, Alfredo|||0000-0003-4991-763X Rossor, M. N. Rubinsztein, D.C. Rujescu, D. Schürmann, B. Sims, Rebecca C. Singh Pahwa, J. Singleton, A. Stretton, A. Thomas, Charlene Todd, S. Williams, A. Williams, J. Williams, K. Wiltfang, J. Younkin, Steven G. Zou, Fanggeng van den Bussche, H. |
| author_facet | Zou, Fanggeng Belbin, Olivia|||0000-0002-6109-6371 Carrasquillo, Minerva M. Culley, Oliver J. Hunter, Talisha A. Ma, Li Bisceglio, Gina D. Allen, Mariet Dickson, Dennis W.|||0000-0001-7189-7917 Graff-Radford, Neill R. Petersen, Ronald C. Morgan, Kevin|||0000-0002-8217-2396 Younkin, Steven G. Harold, Denise|||0000-0001-5195-0143 Sims, Rebecca C. Gerrish, Amy Chapman, Jade A. Moskvina, V. Abraham, Richard Hollingworth, Paul Hamshere, M. Singh Pahwa, J. Dowzell, K. Williams, A. Jones, Nicola Thomas, Charlene Stretton, A. Morgan, A. Williams, K. Lovestone, Simon|||0000-0003-0473-4565 Powell, J. Proitsi, P. Lupton, M.K. Brayne, C. Rubinsztein, D.C. Gill, M. Lawlor, B. Lynch, A. Brown, K. Passmore, P. Craig, D. McGuinness, B. Johnston, J.A. Todd, S. Holmes, Clive Mann, D. David Smith, A. Love, S. Kehoe, P.G. Hardy, J. Guerreiro, Rita|||0000-0001-5879-3486 Singleton, A. Mead, S. Fox, N. Rossor, M. N. Collinge, John Maier, Wolfgang Jessen, Frank Heun, R. Schürmann, B. Ramirez, Alfredo|||0000-0003-4991-763X Herold, C. Lacour, A. Drichel, D. van den Bussche, H. Heuser, I. Kornhuber, Johannes|||0000-0002-8096-3987 Wiltfang, J. Dichgans, Martin|||0000-0002-0654-387X Frölich, L. Hampel, H. Hüll, M. Rujescu, D. Goate, A. Kauwe, J.S.K. Cruchaga, Carlos|||0000-0002-0276-2899 Nowotny, P. Morris, J.C. Mayo, K. Livingston, G. Bass, N.J. Gurling, H. McQuillin, A. Gwilliam, R. Deloukas, P. Nöthen, M.M. Holmans, Peter|||0000-0003-0870-9412 O'Donovan, M. Owen, M.J. Williams, J. |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer's disease (LOAD) with reported odds ratios (ORs) ranging from 0.75-0.85. We tested eight GAB2 variants in four North American Caucasian case-control series (2,316 LOAD, 2,538 controls) for association with LOAD. Meta-analyses revealed ORs ranging from (0.61-1.20) with no significant association (all p. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_e48657279a838ca1aafd9ff95e9bc16f |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:303536 |
| publishDate | 2013 |
| publishDateSort | 2013 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer's Disease Pathology Zou, Fanggeng Belbin, Olivia|||0000-0002-6109-6371 Carrasquillo, Minerva M. Culley, Oliver J. Hunter, Talisha A. Ma, Li Bisceglio, Gina D. Allen, Mariet Dickson, Dennis W.|||0000-0001-7189-7917 Graff-Radford, Neill R. Petersen, Ronald C. Morgan, Kevin|||0000-0002-8217-2396 Younkin, Steven G. Harold, Denise|||0000-0001-5195-0143 Sims, Rebecca C. Gerrish, Amy Chapman, Jade A. Moskvina, V. Abraham, Richard Hollingworth, Paul Hamshere, M. Singh Pahwa, J. Dowzell, K. Williams, A. Jones, Nicola Thomas, Charlene Stretton, A. Morgan, A. Williams, K. Lovestone, Simon|||0000-0003-0473-4565 Powell, J. Proitsi, P. Lupton, M.K. Brayne, C. Rubinsztein, D.C. Gill, M. Lawlor, B. Lynch, A. Brown, K. Passmore, P. Craig, D. McGuinness, B. Johnston, J.A. Todd, S. Holmes, Clive Mann, D. David Smith, A. Love, S. Kehoe, P.G. Hardy, J. Guerreiro, Rita|||0000-0001-5879-3486 Singleton, A. Mead, S. Fox, N. Rossor, M. N. Collinge, John Maier, Wolfgang Jessen, Frank Heun, R. Schürmann, B. Ramirez, Alfredo|||0000-0003-4991-763X Herold, C. Lacour, A. Drichel, D. van den Bussche, H. Heuser, I. Kornhuber, Johannes|||0000-0002-8096-3987 Wiltfang, J. Dichgans, Martin|||0000-0002-0654-387X Frölich, L. Hampel, H. Hüll, M. Rujescu, D. Goate, A. Kauwe, J.S.K. Cruchaga, Carlos|||0000-0002-0276-2899 Nowotny, P. Morris, J.C. Mayo, K. Livingston, G. Bass, N.J. Gurling, H. McQuillin, A. Gwilliam, R. Deloukas, P. Nöthen, M.M. Holmans, Peter|||0000-0003-0870-9412 O'Donovan, M. Owen, M.J. Williams, J. GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer's disease (LOAD) with reported odds ratios (ORs) ranging from 0.75-0.85. We tested eight GAB2 variants in four North American Caucasian case-control series (2,316 LOAD, 2,538 controls) for association with LOAD. Meta-analyses revealed ORs ranging from (0.61-1.20) with no significant association (all p. https://ddd.uab.cat/record/303536 https://dx.doi.org/urn:doi:10.1371/journal.pone.0064802 |
| spellingShingle | Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer's Disease Pathology Zou, Fanggeng |
| title | Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer's Disease Pathology |
| title_full | Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer's Disease Pathology |
| title_fullStr | Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer's Disease Pathology |
| title_full_unstemmed | Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer's Disease Pathology |
| title_short | Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer's Disease Pathology |
| title_sort | Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer's Disease Pathology |
| url | https://ddd.uab.cat/record/303536 https://dx.doi.org/urn:doi:10.1371/journal.pone.0064802 |