Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer's Disease Pathology

GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer's disease (LOAD) with reported odds ratios (ORs) ranging from 0.75-0.85. We tested eight GAB2 variants in four North American Caucasian case-control series (2,316 LOAD, 2,538 contr...

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Autores: Zou, Fanggeng; Belbin, Olivia|||0000-0002-6109-6371; Carrasquillo, Minerva M.; Culley, Oliver J.; Hunter, Talisha A.; Ma, Li; Bisceglio, Gina D.; Allen, Mariet; Dickson, Dennis W.|||0000-0001-7189-7917; Graff-Radford, Neill R.; Petersen, Ronald C.; Morgan, Kevin|||0000-0002-8217-2396; Younkin, Steven G.; Harold, Denise|||0000-0001-5195-0143; Sims, Rebecca C.; Gerrish, Amy; Chapman, Jade A.; Moskvina, V.; Abraham, Richard; Hollingworth, Paul; Hamshere, M.; Singh Pahwa, J.; Dowzell, K.; Williams, A.; Jones, Nicola; Thomas, Charlene; Stretton, A.; Morgan, A.; Williams, K.; Lovestone, Simon|||0000-0003-0473-4565; Powell, J.; Proitsi, P.; Lupton, M.K.; Brayne, C.; Rubinsztein, D.C.; Gill, M.; Lawlor, B.; Lynch, A.; Brown, K.; Passmore, P.; Craig, D.; McGuinness, B.; Johnston, J.A.; Todd, S.; Holmes, Clive; Mann, D.; David Smith, A.; Love, S.; Kehoe, P.G.; Hardy, J.; Guerreiro, Rita|||0000-0001-5879-3486; Singleton, A.; Mead, S.; Fox, N.; Rossor, M. N.; Collinge, John; Maier, Wolfgang; Jessen, Frank; Heun, R.; Schürmann, B.; Ramirez, Alfredo|||0000-0003-4991-763X; Herold, C.; Lacour, A.; Drichel, D.; van den Bussche, H.; Heuser, I.; Kornhuber, Johannes|||0000-0002-8096-3987; Wiltfang, J.; Dichgans, Martin|||0000-0002-0654-387X; Frölich, L.; Hampel, H.; Hüll, M.; Rujescu, D.; Goate, A.; Kauwe, J.S.K.; Cruchaga, Carlos|||0000-0002-0276-2899; Nowotny, P.; Morris, J.C.; Mayo, K.; Livingston, G.; Bass, N.J.; Gurling, H.; McQuillin, A.; Gwilliam, R.; Deloukas, P.; Nöthen, M.M.; Holmans, Peter|||0000-0003-0870-9412; O'Donovan, M.; Owen, M.J.; Williams, J.
Tipo de documento: Artículo
Fecha de publicación:2013
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Lenguaje:Inglés
OAI Identifier:oai:ddd.uab.cat:303536
Acceso en línea:https://ddd.uab.cat/record/303536
https://dx.doi.org/urn:doi:10.1371/journal.pone.0064802
Nivel de acceso:Acceso abierto
Sumario:GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer's disease (LOAD) with reported odds ratios (ORs) ranging from 0.75-0.85. We tested eight GAB2 variants in four North American Caucasian case-control series (2,316 LOAD, 2,538 controls) for association with LOAD. Meta-analyses revealed ORs ranging from (0.61-1.20) with no significant association (all p.

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