MELAS in Latin America
A thematic review on MELAS in Latin America between 1990 and 2021 was conducted through a systematic literature search on LILACs, Scielo, PubMed/Medline and Scopus databases. Nineteen case reports/series out of 966 publications were selected and included 51 patients, 42 of them with genetic diagnosi...
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2022 |
| Country: | Perú |
| Institution: | UPCH |
| Repository: | Revistas - Universidad Peruana Cayetano Heredia |
| Language: | Spanish |
| OAI Identifier: | oai:revistas.upch.edu.pe:article/4137 |
| Online Access: | https://revistas.upch.edu.pe/index.php/RNP/article/view/4137 |
| Access Level: | Open access |
| Keyword: | MELAS syndrome mitochondrial encephalomyopathies mitochondrial diseases mitochondrial genes Síndrome de MELAS enfermedades mitocondriales genes mitocondriales Latinoamérica |
| Summary: | A thematic review on MELAS in Latin America between 1990 and 2021 was conducted through a systematic literature search on LILACs, Scielo, PubMed/Medline and Scopus databases. Nineteen case reports/series out of 966 publications were selected and included 51 patients, 42 of them with genetic diagnosis reported in eight Latin American countries. The m.3243A> G variant was the most frequently reported, the mean age at onset being 12 ± 9.7 years, with a mild female predominance. The most frequent neurological features were stroke-like episodes and seizures. Neuroimaging tests highlighted ischemic stroke-like lesions as well as calcified lesions in the basal ganglia. |
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