PAI-1 haplogenotype confers genetic susceptibility for obesity and hypertriglyceridemia in Mexican children.
The presence of childhood obesity predisposes to the development of cardio - vascular and metabolic diseases, such as coronary artery disease and type 2 diabetes mellitus, in adulthood. The polymorphisms described in PAI-1 gene have been linked with obesity and metabolic syndrome in several populati...
| Authors: | ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2016 |
| Country: | México |
| Institution: | UAGro |
| Repository: | Redalyc-UAGro |
| OAI Identifier: | oai:redalyc.org:372946635003 |
| Online Access: | https://www.redalyc.org/articulo.oa?id=372946635003 https://www.redalyc.org/journal/3729/372946635003/ https://www.redalyc.org/journal/3729/372946635003/html/ https://www.redalyc.org/journal/3729/372946635003/372946635003.epub https://www.redalyc.org/journal/3729/372946635003/movil |
| Access Level: | Open access |
| Keyword: | Medicina PAI obesity children polymorphism hypertriglyceridemia |
| Summary: | The presence of childhood obesity predisposes to the development of cardio - vascular and metabolic diseases, such as coronary artery disease and type 2 diabetes mellitus, in adulthood. The polymorphisms described in PAI-1 gene have been linked with obesity and metabolic syndrome in several populations. The aim of this study was to investigate the as - sociation of the -844 G/A (rs2227631), -675 4G/5G (rs1799889) and HindIII C/G (rs757716) PAI-1 polymorphisms with obesity and dyslipidemia in a sample of Mexican children. A cross-sectional study was performed in 222 children with an age range between 6-11 years; 104 children were classified as obese and 118 children with normal-weight. The PAI-1 poly - morphisms were analyzed by PCR-RFLP. Linkage disequilibrium (LD) and haplogenotype analysis among the three polymorphisms were determined. The results showed significant as - sociations with obesity of the -844 G/A genotype and the A allele (OR= 2.75, p<0.001 and OR= 1.76, p=0.01, respectively). The -844 G/A polymorphism was found in LD with -675 4G/5G PAI-1 polymorphism (D’= 0.77). We found that G-4G-C/A-5G-G is a risk haplogeno - type for obesity [OR=2.6; 95% confidence interval (CI) 1.17-4.22; p= 0.01] and with marginal association with hypertriglyceridemia(OR= 2.6; 95% CI 1.04-6.35; p= 0.05). The G-4G-C/A- 5G-G PAI-1 haplogenotype may be a genetic marker of susceptibility for obesity and hypertri - glyceridemia in Mexican children. |
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