Autoantibodies against Cajal bodies in systemic lupus erythematosus
Cajal bodies (CB) are distinct sub-nuclear domains rich in small nuclear ribonucleoprotein particles (snRNPs); they are involved in pre-mRNA processing. Lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production against different nuclear molecules, including those in...
| Authors: | ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2004 |
| Country: | México |
| Institution: | UAZ |
| Repository: | Repositorio Institucional Caxcán |
| Language: | Spanish |
| OAI Identifier: | oai:http://ricaxcan.uaz.edu.mx:20.500.11845/623 |
| Online Access: | http://hdl.handle.net/20.500.11845/623 |
| Access Level: | Open access |
| Keyword: | BIOLOGIA Y QUIMICA [2] systemic lupus erythematous p80 coilin small nuclear ribonucleoprotein particles (snRNPs) pre-mRNA processing autoantibodies immunofluorescence |
| _version_ | 1878408717144162304 |
|---|---|
| author | Vázquez Talavera, José |
| author2 | Ramírez Sandoval, Roxana Esparza Ibarra, Edgar León Ávalos Díaz, Esperanza del Refugio Herrera Esparza, Rafael |
| author2_role | author author author author |
| author_browse | Esparza Ibarra, Edgar León Herrera Esparza, Rafael Ramírez Sandoval, Roxana Vázquez Talavera, José Ávalos Díaz, Esperanza del Refugio |
| author_facet | Vázquez Talavera, José Ramírez Sandoval, Roxana Esparza Ibarra, Edgar León Ávalos Díaz, Esperanza del Refugio Herrera Esparza, Rafael |
| author_role | author |
| collection | Repositorio Institucional Caxcán |
| description | Cajal bodies (CB) are distinct sub-nuclear domains rich in small nuclear ribonucleoprotein particles (snRNPs); they are involved in pre-mRNA processing. Lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production against different nuclear molecules, including those involved in pre-mRNA processing. The aim of the present investigation is to assess the presence of anti-CB autoantibodies in a cohort of SLE sera. Material/Methods: Antinuclear antibodies (ANA) were screened by indirect immunofluorescence in a batch of 190 sera from patients who met the ACR criteria for SLE classification; fine specificity was determined by Western blot using HEp-2 cells or rat hepatocyte extracts purified by ion exchange chromatography. Results: Four sera had anti-Cajal body (CB) autoantibodies. Interestingly, all of these patients had intermittent extensive oral and esophageal ulceration. The autoantibodies to CB were of the IgG class, and by Western blot these sera had reactivity against an 80 kDa protein (coilin) associated with Sm proteins. Conclusions: Anti-CB autoantibodies constitute an uncommon specificity of SLE; therefore it seems that anti-CB antibody specificity is associated with extensive mucous ulceration. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | MX_711dfd77f68a42a596ef59dc76f65cbd |
| identifier_str_mv | info:eu-repo/semantics/publishedVersion 1643-3750 |
| institution | UAZ |
| instname_str | Universidad Autónoma de Zacatecas |
| language | spa |
| network_acronym_str | MX |
| network_name_str | México |
| oai_identifier_str | oai:http://ricaxcan.uaz.edu.mx:20.500.11845/623 |
| publishDate | 2004 |
| publishDateSort | 2004 |
| publisher | International Scientific Information |
| publisherStr | International Scientific Information |
| reponame_str | Repositorio Institucional Caxcán |
| spelling | Autoantibodies against Cajal bodies in systemic lupus erythematosus Vázquez Talavera, José Ramírez Sandoval, Roxana Esparza Ibarra, Edgar León Ávalos Díaz, Esperanza del Refugio Herrera Esparza, Rafael BIOLOGIA Y QUIMICA [2] systemic lupus erythematous p80 coilin small nuclear ribonucleoprotein particles (snRNPs) pre-mRNA processing autoantibodies immunofluorescence Cajal bodies (CB) are distinct sub-nuclear domains rich in small nuclear ribonucleoprotein particles (snRNPs); they are involved in pre-mRNA processing. Lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production against different nuclear molecules, including those involved in pre-mRNA processing. The aim of the present investigation is to assess the presence of anti-CB autoantibodies in a cohort of SLE sera. Material/Methods: Antinuclear antibodies (ANA) were screened by indirect immunofluorescence in a batch of 190 sera from patients who met the ACR criteria for SLE classification; fine specificity was determined by Western blot using HEp-2 cells or rat hepatocyte extracts purified by ion exchange chromatography. Results: Four sera had anti-Cajal body (CB) autoantibodies. Interestingly, all of these patients had intermittent extensive oral and esophageal ulceration. The autoantibodies to CB were of the IgG class, and by Western blot these sera had reactivity against an 80 kDa protein (coilin) associated with Sm proteins. Conclusions: Anti-CB autoantibodies constitute an uncommon specificity of SLE; therefore it seems that anti-CB antibody specificity is associated with extensive mucous ulceration. International Scientific Information info:eu-repo/semantics/publishedVersion 1643-3750 http://hdl.handle.net/20.500.11845/623 |
| spellingShingle | Autoantibodies against Cajal bodies in systemic lupus erythematosus Vázquez Talavera, José BIOLOGIA Y QUIMICA [2] systemic lupus erythematous p80 coilin small nuclear ribonucleoprotein particles (snRNPs) pre-mRNA processing autoantibodies immunofluorescence |
| status_str | publishedVersion |
| title | Autoantibodies against Cajal bodies in systemic lupus erythematosus |
| title_full | Autoantibodies against Cajal bodies in systemic lupus erythematosus |
| title_fullStr | Autoantibodies against Cajal bodies in systemic lupus erythematosus |
| title_full_unstemmed | Autoantibodies against Cajal bodies in systemic lupus erythematosus |
| title_short | Autoantibodies against Cajal bodies in systemic lupus erythematosus |
| title_sort | Autoantibodies against Cajal bodies in systemic lupus erythematosus |
| topic | BIOLOGIA Y QUIMICA [2] systemic lupus erythematous p80 coilin small nuclear ribonucleoprotein particles (snRNPs) pre-mRNA processing autoantibodies immunofluorescence |
| topic_facet | BIOLOGIA Y QUIMICA [2] systemic lupus erythematous p80 coilin small nuclear ribonucleoprotein particles (snRNPs) pre-mRNA processing autoantibodies immunofluorescence |
| url | http://hdl.handle.net/20.500.11845/623 |