BRAF, MEK and EGFR inhibition as treatment strategies in BRAF V600E metastatic colorectal cancer
Inhibidor de BRAF; Binimetinib; Cáncer de colon
| Authors: | ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2021 |
| Country: | España |
| Institution: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repository: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/7159 |
| Online Access: | https://hdl.handle.net/11351/7159 |
| Access Level: | Open access |
| Keyword: | Còlon - Càncer - Tractament Recte - Càncer - Tractament Metàstasi DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Metastasis ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia ENFERMEDADES::neoplasias::procesos neoplásicos::metástasis neoplásica |
| _version_ | 1878742981125603328 |
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| author | Ros Montañá, Fco. Javier |
| author2 | Baraibar Argota, Iosune Sardo, Emilia Mulet Margalef, Núria Salva Ballabrera, Francesc Argilés Martinez, Guillem Ciardiello, Davide Tabernero Caturla, Josep Elez Fernandez, Mª Elena Martini, Giulia |
| author2_role | author author author author author author author author author |
| author_browse | Argilés Martinez, Guillem Baraibar Argota, Iosune Ciardiello, Davide Elez Fernandez, Mª Elena Martini, Giulia Mulet Margalef, Núria Ros Montañá, Fco. Javier Salva Ballabrera, Francesc Sardo, Emilia Tabernero Caturla, Josep |
| author_facet | Ros Montañá, Fco. Javier Baraibar Argota, Iosune Sardo, Emilia Mulet Margalef, Núria Salva Ballabrera, Francesc Argilés Martinez, Guillem Ciardiello, Davide Tabernero Caturla, Josep Elez Fernandez, Mª Elena Martini, Giulia |
| author_role | author |
| collection | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| description | Inhibidor de BRAF; Binimetinib; Cáncer de colon |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_ffbf60ab9b76b8a082decfe790cffe4d |
| institution | Departament de Salut de la Generalitat de Catalunya (DS) |
| instname_str | Departament de Salut de la Generalitat de Catalunya (DS) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:scientiasalut.gencat.cat:11351/7159 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher | SAGE Publications |
| publisherStr | SAGE Publications |
| reponame_str | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| spelling | BRAF, MEK and EGFR inhibition as treatment strategies in BRAF V600E metastatic colorectal cancer Ros Montañá, Fco. Javier Baraibar Argota, Iosune Sardo, Emilia Mulet Margalef, Núria Salva Ballabrera, Francesc Argilés Martinez, Guillem Ciardiello, Davide Tabernero Caturla, Josep Elez Fernandez, Mª Elena Martini, Giulia Còlon - Càncer - Tractament Recte - Càncer - Tractament Metàstasi DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Metastasis ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia ENFERMEDADES::neoplasias::procesos neoplásicos::metástasis neoplásica Inhibidor de BRAF; Binimetinib; Cáncer de colon BRAF inhibitor; Binimetinib; Colon cancer Inhibidor de BRAF; Binimetinib; Càncer de còlon Introduction: BRAF driver mutations are found in up to 15% of patients with colorectal cancer (CRC) and lead to constitutive activation of BRAF kinase and sustained RAS/RAF/MEK/ERK pathway signaling. BRAF mutations define a sub-population characterized by a poor prognosis and dismal median survival. Following successful outcomes with BRAF inhibition in BRAF mutant metastatic melanoma, this approach was evaluated in metastatic colorectal cancer (mCRC). The development and combination of targeted therapies against multiple signaling pathways has proved particularly successful, with improved survival and response rates. Areas covered: This review addresses the development of therapeutic strategies with inhibitors targeting MAPK/ERK and EGFR signaling in BRAF V600E mutated mCRC, focusing on encorafenib, binimetinib and cetuximab. A pharmacological and clinical review of these drugs and the therapeutic approaches behind their optimization are presented. Expert opinion: Exploiting knowledge of the mechanisms of resistance to BRAF inhibitors has been crucial to developing effective therapeutic strategies in BRAF-V600E mutant mCRC. The BEACON trial is a successful example of this approach, using encorafenib and cetuximab with or without binimetinib in patients with previously treated BRAF V600E mutant mCRC, showing an impressive improvement in clinical outcomes and tolerable toxicity compared with chemotherapy, establishing a new standard of care in this setting. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by grants from Instituto de Salud Carlos III (ISCIII) FIS/FEDER (PI17/00947, PI20/00968) and from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 635342. SAGE Publications https://hdl.handle.net/11351/7159 |
| spellingShingle | BRAF, MEK and EGFR inhibition as treatment strategies in BRAF V600E metastatic colorectal cancer Ros Montañá, Fco. Javier Còlon - Càncer - Tractament Recte - Càncer - Tractament Metàstasi DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Metastasis ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia ENFERMEDADES::neoplasias::procesos neoplásicos::metástasis neoplásica |
| status_str | publishedVersion |
| title | BRAF, MEK and EGFR inhibition as treatment strategies in BRAF V600E metastatic colorectal cancer |
| title_full | BRAF, MEK and EGFR inhibition as treatment strategies in BRAF V600E metastatic colorectal cancer |
| title_fullStr | BRAF, MEK and EGFR inhibition as treatment strategies in BRAF V600E metastatic colorectal cancer |
| title_full_unstemmed | BRAF, MEK and EGFR inhibition as treatment strategies in BRAF V600E metastatic colorectal cancer |
| title_short | BRAF, MEK and EGFR inhibition as treatment strategies in BRAF V600E metastatic colorectal cancer |
| title_sort | BRAF, MEK and EGFR inhibition as treatment strategies in BRAF V600E metastatic colorectal cancer |
| topic | Còlon - Càncer - Tractament Recte - Càncer - Tractament Metàstasi DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Metastasis ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia ENFERMEDADES::neoplasias::procesos neoplásicos::metástasis neoplásica |
| topic_facet | Còlon - Càncer - Tractament Recte - Càncer - Tractament Metàstasi DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Metastasis ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia ENFERMEDADES::neoplasias::procesos neoplásicos::metástasis neoplásica |
| url | https://hdl.handle.net/11351/7159 |