Bovine host genome acts on rumen microbiome function linked to methane emissions
[EN] Our study provides substantial evidence that the host genome affects the comprehensive function of the microbiome in the rumen of bovines. Of 1,107/225/1,141 rumen microbial genera/metagenome assembled uncultured genomes (RUGs)/genes identified from whole metagenomics sequencing, 194/14/337 had...
| Autores: | ; ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:riunet.upv.es:10251/232548 |
| Acceso en línea: | https://riunet.upv.es/handle/10251/232548 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Rumen microbiome Host genomic control Methane emissions Bovine genetics Microbiome heritability Greenhouse gas mitigation |
| _version_ | 1878742900985036800 |
|---|---|
| author | Martínez-Álvaro, Marina|||0000-0003-2295-5839 |
| author2 | Auffret, Marc D. Duthie, Carol-Anne Dewhurst, Richard J. Cleveland, Matthew A. Watson, Mick Roehe, Rainer |
| author2_role | author author author author author author |
| author_browse | Auffret, Marc D. Cleveland, Matthew A. Dewhurst, Richard J. Duthie, Carol-Anne Martínez-Álvaro, Marina|||0000-0003-2295-5839 Roehe, Rainer Watson, Mick |
| author_facet | Martínez-Álvaro, Marina|||0000-0003-2295-5839 Auffret, Marc D. Duthie, Carol-Anne Dewhurst, Richard J. Cleveland, Matthew A. Watson, Mick Roehe, Rainer |
| author_role | author |
| collection | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| description | [EN] Our study provides substantial evidence that the host genome affects the comprehensive function of the microbiome in the rumen of bovines. Of 1,107/225/1,141 rumen microbial genera/metagenome assembled uncultured genomes (RUGs)/genes identified from whole metagenomics sequencing, 194/14/337 had significant host genomic effects (heritabilities ranging from 0.13 to 0.61), revealing that substantial variation of the microbiome is under host genomic control. We found 29/22/115 microbial genera/RUGs/genes host-genomically correlated (|0.59| to |0.93|) with emissions of the potent greenhouse gas methane (CH4), highlighting the strength of a common host genomic control of specific microbial processes and CH4. Only one of these microbial genes was directly involved in methanogenesis (cofG), whereas others were involved in providing substrates for archaea (e.g. bcd and pccB), important microbial interspecies communication mechanisms (ABC.PE.P), host-microbiome interaction (TSTA3) and genetic information processes (RP-L35). In our population, selection based on abundances of the 30 most informative microbial genes provided a mitigation potential of 17% of mean CH4 emissions per generation, which is higher than for selection based on measured CH4 using respiration chambers (13%), indicating the high potential of microbiome-driven breeding to cumulatively reduce CH4 emissions and mitigate climate change. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_fe4b4e00417fe7e72a1f70d31fe8a5bd |
| institution | Universitat Politècnica de València (UPV) |
| instname_str | Universitat Politècnica de València (UPV) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:riunet.upv.es:10251/232548 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher | Springer Nature |
| publisherStr | Springer Nature |
| reponame_str | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| spelling | Bovine host genome acts on rumen microbiome function linked to methane emissions Martínez-Álvaro, Marina|||0000-0003-2295-5839 Auffret, Marc D. Duthie, Carol-Anne Dewhurst, Richard J. Cleveland, Matthew A. Watson, Mick Roehe, Rainer Rumen microbiome Host genomic control Methane emissions Bovine genetics Microbiome heritability Greenhouse gas mitigation [EN] Our study provides substantial evidence that the host genome affects the comprehensive function of the microbiome in the rumen of bovines. Of 1,107/225/1,141 rumen microbial genera/metagenome assembled uncultured genomes (RUGs)/genes identified from whole metagenomics sequencing, 194/14/337 had significant host genomic effects (heritabilities ranging from 0.13 to 0.61), revealing that substantial variation of the microbiome is under host genomic control. We found 29/22/115 microbial genera/RUGs/genes host-genomically correlated (|0.59| to |0.93|) with emissions of the potent greenhouse gas methane (CH4), highlighting the strength of a common host genomic control of specific microbial processes and CH4. Only one of these microbial genes was directly involved in methanogenesis (cofG), whereas others were involved in providing substrates for archaea (e.g. bcd and pccB), important microbial interspecies communication mechanisms (ABC.PE.P), host-microbiome interaction (TSTA3) and genetic information processes (RP-L35). In our population, selection based on abundances of the 30 most informative microbial genes provided a mitigation potential of 17% of mean CH4 emissions per generation, which is higher than for selection based on measured CH4 using respiration chambers (13%), indicating the high potential of microbiome-driven breeding to cumulatively reduce CH4 emissions and mitigate climate change. Springer Nature https://riunet.upv.es/handle/10251/232548 |
| spellingShingle | Bovine host genome acts on rumen microbiome function linked to methane emissions Martínez-Álvaro, Marina|||0000-0003-2295-5839 Rumen microbiome Host genomic control Methane emissions Bovine genetics Microbiome heritability Greenhouse gas mitigation |
| title | Bovine host genome acts on rumen microbiome function linked to methane emissions |
| title_full | Bovine host genome acts on rumen microbiome function linked to methane emissions |
| title_fullStr | Bovine host genome acts on rumen microbiome function linked to methane emissions |
| title_full_unstemmed | Bovine host genome acts on rumen microbiome function linked to methane emissions |
| title_short | Bovine host genome acts on rumen microbiome function linked to methane emissions |
| title_sort | Bovine host genome acts on rumen microbiome function linked to methane emissions |
| topic | Rumen microbiome Host genomic control Methane emissions Bovine genetics Microbiome heritability Greenhouse gas mitigation |
| topic_facet | Rumen microbiome Host genomic control Methane emissions Bovine genetics Microbiome heritability Greenhouse gas mitigation |
| url | https://riunet.upv.es/handle/10251/232548 |