Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models
Introduction: Chronic reduction of oxygen and nutrient delivery to the fetus has been related to neurodevelopmental problems. Placental underperfusion induces a significant reduction in oxygen and nutrient delivery, whereas maternal undernutrition causes mainly nutrient deficiency. A comparison of t...
| Authors: | ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Accepted version |
| Publication date: | 2017 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/125371 |
| Online Access: | https://hdl.handle.net/2445/125371 |
| Access Level: | Open access |
| Keyword: | Malnutrició Retard del creixement intrauterí Neonatologia Models animals en la investigació Malnutrition Fetal growth retardation Neonatology Animal models in research |
| _version_ | 1878742880336478208 |
|---|---|
| author | Illa Armengol, Míriam |
| author2 | Eixarch Roca, Elisenda Muñoz-Moreno, Emma Batallé Bolaño, Dafnis Leal Campanario, Rocio Gruart i Massó, Agnès Delgado Garcia, José M. Figueras Retuerta, Francesc Gratacós Solsona, Eduard |
| author2_role | author author author author author author author author |
| author_browse | Batallé Bolaño, Dafnis Delgado Garcia, José M. Eixarch Roca, Elisenda Figueras Retuerta, Francesc Gratacós Solsona, Eduard Gruart i Massó, Agnès Illa Armengol, Míriam Leal Campanario, Rocio Muñoz-Moreno, Emma |
| author_facet | Illa Armengol, Míriam Eixarch Roca, Elisenda Muñoz-Moreno, Emma Batallé Bolaño, Dafnis Leal Campanario, Rocio Gruart i Massó, Agnès Delgado Garcia, José M. Figueras Retuerta, Francesc Gratacós Solsona, Eduard |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Introduction: Chronic reduction of oxygen and nutrient delivery to the fetus has been related to neurodevelopmental problems. Placental underperfusion induces a significant reduction in oxygen and nutrient delivery, whereas maternal undernutrition causes mainly nutrient deficiency. A comparison of the neurodevelopmental effects of both situations in pregnant rabbits was performed. Materials and Methods: The placental underperfusion model was induced after uteroplacental vessel ligation at 25 days of pregnancy. The undernutrition model was induced after a reduction of 70% of the basal maternal intake at 22 days of pregnancy. Neurobehavioral tests were applied in the derived offspring at the neonatal period and over the long term. Structural brain differences were evaluated by brain networks obtained from diffusion magnetic resonance imaging. Results: Birth weight was significantly lower in both cases. However, stillbirth was only increased in the placental underperfusion model. Cases from both models presented poorer neurobehavioral performance and network infrastructure, being more pro-nounced in the placental underperfusion model. Discussion: Prenatal insults during the last third of gestation resulted in functional and structural disturbances. The degree of neurodevelopmental impairment and its association with structural brain reorganization seemed to be related to the type of the prenatal insult, showing stronger effects in the placental underperfusion model. (C) 2017 S. Karger AG, Basel |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_fdef237f8a42e7a7917e9c8ac2c4afbe |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/125371 |
| publishDate | 2017 |
| publishDateSort | 2017 |
| publisher | Karger |
| publisherStr | Karger |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models Illa Armengol, Míriam Eixarch Roca, Elisenda Muñoz-Moreno, Emma Batallé Bolaño, Dafnis Leal Campanario, Rocio Gruart i Massó, Agnès Delgado Garcia, José M. Figueras Retuerta, Francesc Gratacós Solsona, Eduard Malnutrició Retard del creixement intrauterí Neonatologia Models animals en la investigació Malnutrition Fetal growth retardation Neonatology Animal models in research Introduction: Chronic reduction of oxygen and nutrient delivery to the fetus has been related to neurodevelopmental problems. Placental underperfusion induces a significant reduction in oxygen and nutrient delivery, whereas maternal undernutrition causes mainly nutrient deficiency. A comparison of the neurodevelopmental effects of both situations in pregnant rabbits was performed. Materials and Methods: The placental underperfusion model was induced after uteroplacental vessel ligation at 25 days of pregnancy. The undernutrition model was induced after a reduction of 70% of the basal maternal intake at 22 days of pregnancy. Neurobehavioral tests were applied in the derived offspring at the neonatal period and over the long term. Structural brain differences were evaluated by brain networks obtained from diffusion magnetic resonance imaging. Results: Birth weight was significantly lower in both cases. However, stillbirth was only increased in the placental underperfusion model. Cases from both models presented poorer neurobehavioral performance and network infrastructure, being more pro-nounced in the placental underperfusion model. Discussion: Prenatal insults during the last third of gestation resulted in functional and structural disturbances. The degree of neurodevelopmental impairment and its association with structural brain reorganization seemed to be related to the type of the prenatal insult, showing stronger effects in the placental underperfusion model. (C) 2017 S. Karger AG, Basel Karger https://hdl.handle.net/2445/125371 |
| spellingShingle | Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models Illa Armengol, Míriam Malnutrició Retard del creixement intrauterí Neonatologia Models animals en la investigació Malnutrition Fetal growth retardation Neonatology Animal models in research |
| status_str | acceptedVersion |
| title | Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models |
| title_full | Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models |
| title_fullStr | Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models |
| title_full_unstemmed | Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models |
| title_short | Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models |
| title_sort | Neurodevelopmental effects of undernutrition and placental underperfusion in fetal growth restriction rabbit models |
| topic | Malnutrició Retard del creixement intrauterí Neonatologia Models animals en la investigació Malnutrition Fetal growth retardation Neonatology Animal models in research |
| topic_facet | Malnutrició Retard del creixement intrauterí Neonatologia Models animals en la investigació Malnutrition Fetal growth retardation Neonatology Animal models in research |
| url | https://hdl.handle.net/2445/125371 |