Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding
Feed efficiency (FE) is one of the most economically and environmentally relevant traits in the animal production sector. The objective of this study was to gain knowledge about the genetic control of FE in rabbits. To this end, GWASs were conducted for individual growth under two feeding regimes (f...
| Authors: | ; ; ; ; ; ; ; |
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| Format: | Article |
| Publication date: | 2020 |
| Country: | España |
| Institution: | Universitat Autònoma de Barcelona |
| Repository: | Dipòsit Digital de Documents de la UAB |
| Language: | English |
| OAI Identifier: | oai:ddd.uab.cat:236999 |
| Online Access: | https://ddd.uab.cat/record/236999 https://dx.doi.org/urn:doi:10.1111/age.12988 |
| Access Level: | Open access |
| Keyword: | Candidate gene Feed efficiency Genome-wide association study Growth Pooled records Rabbit Restricted feeding |
| _version_ | 1878742812103540736 |
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| author | Sánchez, Juan Pablo|||0000-0001-8639-6146 |
| author2 | Legarra, Andres Velasco-Galilea, M. Piles, Miriam|||0000-0001-8265-9930 Sánchez Bonastre, Armando|||0000-0001-9160-1124 Rafel Guarro, Oriol González-Rodríguez, Olga Ballester Devis, Maria|||0000-0002-5413-4640 |
| author2_role | author author author author author author author |
| author_browse | Ballester Devis, Maria|||0000-0002-5413-4640 González-Rodríguez, Olga Legarra, Andres Piles, Miriam|||0000-0001-8265-9930 Rafel Guarro, Oriol Sánchez Bonastre, Armando|||0000-0001-9160-1124 Sánchez, Juan Pablo|||0000-0001-8639-6146 Velasco-Galilea, M. |
| author_facet | Sánchez, Juan Pablo|||0000-0001-8639-6146 Legarra, Andres Velasco-Galilea, M. Piles, Miriam|||0000-0001-8265-9930 Sánchez Bonastre, Armando|||0000-0001-9160-1124 Rafel Guarro, Oriol González-Rodríguez, Olga Ballester Devis, Maria|||0000-0002-5413-4640 |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | Feed efficiency (FE) is one of the most economically and environmentally relevant traits in the animal production sector. The objective of this study was to gain knowledge about the genetic control of FE in rabbits. To this end, GWASs were conducted for individual growth under two feeding regimes (full feeding and restricted) and FE traits collected from cage groups, using 114 604 autosome SNPs segregating in 438 rabbits. Two different models were implemented: (1) an animal model with a linear regression on each SNP allele for growth trait; and (2) a two-trait animal model, jointly fitting the performance trait and each SNP allele content, for FE traits. This last modeling strategy is a new tool applied to GWAS and allows information to be considered from non-genotyped individuals whose contribution is relevant in the group average traits. A total of 189 SNPs in 17 chromosomal regions were declared to be significantly associated with any of the five analyzed traits at a chromosome-wide level. In 12 of these regions, 20 candidate genes were proposed to explain the variation of the analyzed traits, including genes such as FTO, NDUFAF6 and CEBPA previously associated with growth and FE traits in monogastric species. Candidate genes associated with behavioral patterns were also identified. Overall, our results can be considered as the foundation for future functional research to unravel the actual causal mutations regulating growth and FE in rabbits. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_fcb49a0c40df5cba2eaa9387ea2afbfb |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:236999 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding Sánchez, Juan Pablo|||0000-0001-8639-6146 Legarra, Andres Velasco-Galilea, M. Piles, Miriam|||0000-0001-8265-9930 Sánchez Bonastre, Armando|||0000-0001-9160-1124 Rafel Guarro, Oriol González-Rodríguez, Olga Ballester Devis, Maria|||0000-0002-5413-4640 Candidate gene Feed efficiency Genome-wide association study Growth Pooled records Rabbit Restricted feeding Feed efficiency (FE) is one of the most economically and environmentally relevant traits in the animal production sector. The objective of this study was to gain knowledge about the genetic control of FE in rabbits. To this end, GWASs were conducted for individual growth under two feeding regimes (full feeding and restricted) and FE traits collected from cage groups, using 114 604 autosome SNPs segregating in 438 rabbits. Two different models were implemented: (1) an animal model with a linear regression on each SNP allele for growth trait; and (2) a two-trait animal model, jointly fitting the performance trait and each SNP allele content, for FE traits. This last modeling strategy is a new tool applied to GWAS and allows information to be considered from non-genotyped individuals whose contribution is relevant in the group average traits. A total of 189 SNPs in 17 chromosomal regions were declared to be significantly associated with any of the five analyzed traits at a chromosome-wide level. In 12 of these regions, 20 candidate genes were proposed to explain the variation of the analyzed traits, including genes such as FTO, NDUFAF6 and CEBPA previously associated with growth and FE traits in monogastric species. Candidate genes associated with behavioral patterns were also identified. Overall, our results can be considered as the foundation for future functional research to unravel the actual causal mutations regulating growth and FE in rabbits. https://ddd.uab.cat/record/236999 https://dx.doi.org/urn:doi:10.1111/age.12988 |
| spellingShingle | Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding Sánchez, Juan Pablo|||0000-0001-8639-6146 Candidate gene Feed efficiency Genome-wide association study Growth Pooled records Rabbit Restricted feeding |
| title | Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding |
| title_full | Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding |
| title_fullStr | Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding |
| title_full_unstemmed | Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding |
| title_short | Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding |
| title_sort | Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding |
| topic | Candidate gene Feed efficiency Genome-wide association study Growth Pooled records Rabbit Restricted feeding |
| topic_facet | Candidate gene Feed efficiency Genome-wide association study Growth Pooled records Rabbit Restricted feeding |
| url | https://ddd.uab.cat/record/236999 https://dx.doi.org/urn:doi:10.1111/age.12988 |