Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes
Ethyl alpha-N-lauroyl L-arginate hydrochloride (LAE) was coupled with hyaluronic acid (HyA) 2 to form ionic complexes with LAE to HyA ratios of 1:1 and 1:2. The complexes were extensively 3 characterized by FTIR and NMR spectroscopies and their thermal properties evaluated by 4 thermogravimetry and...
| Authors: | ; ; ; ; |
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| Format: | Article |
| Publication date: | 2018 |
| Country: | España |
| Institution: | Universitat Politècnica de Catalunya (UPC) |
| Repository: | UPCommons. Portal del coneixement obert de la UPC |
| Language: | English |
| OAI Identifier: | oai:upcommons.upc.edu:2117/122201 |
| Online Access: | https://hdl.handle.net/2117/122201 https://dx.doi.org/10.1016/j.carbpol.2018.05.057 |
| Access Level: | Open access |
| Keyword: | Antimicrobial polymers Ethyl alpha-N-lauroyl L-arginate LAE hyaluronic acid ionic complexes biocide activity Biopolímers Àrees temàtiques de la UPC::Enginyeria química |
| _version_ | 1878742724168908800 |
|---|---|
| author | Gamarra Montes, Ana|||0000-0002-7163-716X |
| author2 | Missagia, Beatriz Urpí Garriga, Lourdes|||0000-0002-2356-033X Morató Farreras, Jordi|||0000-0003-2588-8846 Muñoz Guerra, Sebastián|||0000-0002-4273-2301 |
| author2_role | author author author author |
| author_browse | Gamarra Montes, Ana|||0000-0002-7163-716X Missagia, Beatriz Morató Farreras, Jordi|||0000-0003-2588-8846 Muñoz Guerra, Sebastián|||0000-0002-4273-2301 Urpí Garriga, Lourdes|||0000-0002-2356-033X |
| author_facet | Gamarra Montes, Ana|||0000-0002-7163-716X Missagia, Beatriz Urpí Garriga, Lourdes|||0000-0002-2356-033X Morató Farreras, Jordi|||0000-0003-2588-8846 Muñoz Guerra, Sebastián|||0000-0002-4273-2301 |
| author_role | author |
| collection | UPCommons. Portal del coneixement obert de la UPC |
| description | Ethyl alpha-N-lauroyl L-arginate hydrochloride (LAE) was coupled with hyaluronic acid (HyA) 2 to form ionic complexes with LAE to HyA ratios of 1:1 and 1:2. The complexes were extensively 3 characterized by FTIR and NMR spectroscopies and their thermal properties evaluated by 4 thermogravimetry and calorimetry. Thin films prepared from these complexes by casting 5 displayed a smectic-like structure based on an ordered arrangement of LAE and HyA layers 6 with a nanometric periodicity of 3.8-3.9 nm. Films immersed in water at pH 7.4 and 5.5 7 dissociated to deliver free LAE to the environment and reaching the equilibrium in few hours. 8 The biocide activity of these films against both Gram-positive and Gram-negative bacteria was 9 preliminary assessed by the liquid medium method, and shown to be notable in both cases. The 10 antibacterial property of the complexes was found to increase with the content of LAE and to be 11 particularly efficient against Gram-negative S. enterica bacteria. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_fb17e04871cc7ffecd0e25da71db9fa7 |
| institution | Universitat Politècnica de Catalunya (UPC) |
| instname_str | Universitat Politècnica de Catalunya (UPC) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:upcommons.upc.edu:2117/122201 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| reponame_str | UPCommons. Portal del coneixement obert de la UPC |
| spelling | Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes Gamarra Montes, Ana|||0000-0002-7163-716X Missagia, Beatriz Urpí Garriga, Lourdes|||0000-0002-2356-033X Morató Farreras, Jordi|||0000-0003-2588-8846 Muñoz Guerra, Sebastián|||0000-0002-4273-2301 Antimicrobial polymers Ethyl alpha-N-lauroyl L-arginate LAE hyaluronic acid ionic complexes biocide activity Biopolímers Àrees temàtiques de la UPC::Enginyeria química Ethyl alpha-N-lauroyl L-arginate hydrochloride (LAE) was coupled with hyaluronic acid (HyA) 2 to form ionic complexes with LAE to HyA ratios of 1:1 and 1:2. The complexes were extensively 3 characterized by FTIR and NMR spectroscopies and their thermal properties evaluated by 4 thermogravimetry and calorimetry. Thin films prepared from these complexes by casting 5 displayed a smectic-like structure based on an ordered arrangement of LAE and HyA layers 6 with a nanometric periodicity of 3.8-3.9 nm. Films immersed in water at pH 7.4 and 5.5 7 dissociated to deliver free LAE to the environment and reaching the equilibrium in few hours. 8 The biocide activity of these films against both Gram-positive and Gram-negative bacteria was 9 preliminary assessed by the liquid medium method, and shown to be notable in both cases. The 10 antibacterial property of the complexes was found to increase with the content of LAE and to be 11 particularly efficient against Gram-negative S. enterica bacteria. Peer Reviewed https://hdl.handle.net/2117/122201 https://dx.doi.org/10.1016/j.carbpol.2018.05.057 |
| spellingShingle | Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes Gamarra Montes, Ana|||0000-0002-7163-716X Antimicrobial polymers Ethyl alpha-N-lauroyl L-arginate LAE hyaluronic acid ionic complexes biocide activity Biopolímers Àrees temàtiques de la UPC::Enginyeria química |
| title | Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes |
| title_full | Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes |
| title_fullStr | Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes |
| title_full_unstemmed | Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes |
| title_short | Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes |
| title_sort | Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes |
| topic | Antimicrobial polymers Ethyl alpha-N-lauroyl L-arginate LAE hyaluronic acid ionic complexes biocide activity Biopolímers Àrees temàtiques de la UPC::Enginyeria química |
| topic_facet | Antimicrobial polymers Ethyl alpha-N-lauroyl L-arginate LAE hyaluronic acid ionic complexes biocide activity Biopolímers Àrees temàtiques de la UPC::Enginyeria química |
| url | https://hdl.handle.net/2117/122201 https://dx.doi.org/10.1016/j.carbpol.2018.05.057 |