Genome wide association study of growth and feed efficiency traits in rabbits
[EN] Feed efficiency is a major production trait in animal genetic breeding schemes. To further investigate the genetic control of feed efficiency in rabbits, we performed a genome-wide association study (GWAS) for growth and feed efficiency on 679 rabbits genotyped with the Affimetrix Axiom Rabbit...
| Autores: | ; ; ; ; ; ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:riunet.upv.es:10251/199168 |
| Acceso en línea: | https://riunet.upv.es/handle/10251/199168 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Feed efficiency SNP GWAS Genetics Candidate genes Rabbits |
| _version_ | 1878742706164858880 |
|---|---|
| author | Garreau, Hervé |
| author2 | Labrune, Yann Chapuis, Hervé Ruesche, Julien Riquet, Juliette Demars, Julie Benitez, Florence Richard, François Drouilhet, Laurence Zemb, Olivier Gilbert, Hélène |
| author2_role | author author author author author author author author author author |
| author_browse | Benitez, Florence Chapuis, Hervé Demars, Julie Drouilhet, Laurence Garreau, Hervé Gilbert, Hélène Labrune, Yann Richard, François Riquet, Juliette Ruesche, Julien Zemb, Olivier |
| author_facet | Garreau, Hervé Labrune, Yann Chapuis, Hervé Ruesche, Julien Riquet, Juliette Demars, Julie Benitez, Florence Richard, François Drouilhet, Laurence Zemb, Olivier Gilbert, Hélène |
| author_role | author |
| collection | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| description | [EN] Feed efficiency is a major production trait in animal genetic breeding schemes. To further investigate the genetic control of feed efficiency in rabbits, we performed a genome-wide association study (GWAS) for growth and feed efficiency on 679 rabbits genotyped with the Affimetrix Axiom Rabbit 200K Genotyping Array. After quality control, 127 847 single-nucleotide polymorphisms (SNP) were retained for association analyses. The GWAS were performed using GEMMA software, applying a mixed univariate animal model with a linear regression on each SNP allele. The traits analysed were weight at weaning and at 63 days of age, average daily gain, total individual feed intake, feed conversion ratio and residual feed intake. No significant SNP was found for growth traits or feed intake. Fifteen genome-wide significant SNPs were detected for feed conversion ratio on OCU7, spanning from 124.8 Mbp to 126.3 Mbp, plus two isolated SNP on OCU2 (77.3 Mbp) and OCU8 (16.5 Mbp). For residual feed intake, a region on OCU18 (46.1-53.0 Mbp) was detected, which contained a putative functional candidate gene, GOT1. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_fac5519634d4c802419c22978ea5762a |
| institution | Universitat Politècnica de València (UPV) |
| instname_str | Universitat Politècnica de València (UPV) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:riunet.upv.es:10251/199168 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher | Universitat Politècnica de València |
| publisherStr | Universitat Politècnica de València |
| reponame_str | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| spelling | Genome wide association study of growth and feed efficiency traits in rabbits Garreau, Hervé Labrune, Yann Chapuis, Hervé Ruesche, Julien Riquet, Juliette Demars, Julie Benitez, Florence Richard, François Drouilhet, Laurence Zemb, Olivier Gilbert, Hélène Feed efficiency SNP GWAS Genetics Candidate genes Rabbits [EN] Feed efficiency is a major production trait in animal genetic breeding schemes. To further investigate the genetic control of feed efficiency in rabbits, we performed a genome-wide association study (GWAS) for growth and feed efficiency on 679 rabbits genotyped with the Affimetrix Axiom Rabbit 200K Genotyping Array. After quality control, 127 847 single-nucleotide polymorphisms (SNP) were retained for association analyses. The GWAS were performed using GEMMA software, applying a mixed univariate animal model with a linear regression on each SNP allele. The traits analysed were weight at weaning and at 63 days of age, average daily gain, total individual feed intake, feed conversion ratio and residual feed intake. No significant SNP was found for growth traits or feed intake. Fifteen genome-wide significant SNPs were detected for feed conversion ratio on OCU7, spanning from 124.8 Mbp to 126.3 Mbp, plus two isolated SNP on OCU2 (77.3 Mbp) and OCU8 (16.5 Mbp). For residual feed intake, a region on OCU18 (46.1-53.0 Mbp) was detected, which contained a putative functional candidate gene, GOT1. This study is part of the Feed-a-Gene Project, funded from the European Union’s H2020 Programme under grant agreement nº 633 531. Universitat Politècnica de València https://riunet.upv.es/handle/10251/199168 |
| spellingShingle | Genome wide association study of growth and feed efficiency traits in rabbits Garreau, Hervé Feed efficiency SNP GWAS Genetics Candidate genes Rabbits |
| title | Genome wide association study of growth and feed efficiency traits in rabbits |
| title_full | Genome wide association study of growth and feed efficiency traits in rabbits |
| title_fullStr | Genome wide association study of growth and feed efficiency traits in rabbits |
| title_full_unstemmed | Genome wide association study of growth and feed efficiency traits in rabbits |
| title_short | Genome wide association study of growth and feed efficiency traits in rabbits |
| title_sort | Genome wide association study of growth and feed efficiency traits in rabbits |
| topic | Feed efficiency SNP GWAS Genetics Candidate genes Rabbits |
| topic_facet | Feed efficiency SNP GWAS Genetics Candidate genes Rabbits |
| url | https://riunet.upv.es/handle/10251/199168 |