Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds
Hyperbaric oxygen therapy (HBOT) is the clinical application of oxygen at pressures higher than atmospheric pressure. HBOT has been effectively used to manage diverse clinical pathologies, such as non-healing diabetic ulcers. The aim of the present study was to analyse the effects of HBOT on the pla...
| Authors: | ; ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2023 |
| Country: | España |
| Institution: | Instituto de Salud Carlos III (ISCIII) |
| Repository: | Repisalud |
| Language: | English |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/23678 |
| Online Access: | https://hdl.handle.net/20.500.12105/23678 |
| Access Level: | Open access |
| Keyword: | Diabetes Mellitus Humanos Biomarcadores Oxigenación Hiperbárica Inflamación Estrés Oxidativo Cicatrización de Heridas Péptidos y Proteínas de Señalización Intercelular Pie Diabético Wound Healing Diabetic Foot Oxidative Stress Biomarkers Humans Intercellular Signaling Peptides and Proteins Inflammation Hyperbaric Oxygenation |
| _version_ | 1878742682039222273 |
|---|---|
| author | Capó Fiol, Xavier |
| author2 | Monserrat-Mesquida, Margalida Quetglas-Llabrés, Magdalena Batle, Juan M Tur, Josep A Pons, Antoni Sureda Gomila, Antoni Tejada Gavela, Silvia |
| author2_role | author author author author author author author |
| author_browse | Batle, Juan M Capó Fiol, Xavier Monserrat-Mesquida, Margalida Pons, Antoni Quetglas-Llabrés, Magdalena Sureda Gomila, Antoni Tejada Gavela, Silvia Tur, Josep A |
| author_facet | Capó Fiol, Xavier Monserrat-Mesquida, Margalida Quetglas-Llabrés, Magdalena Batle, Juan M Tur, Josep A Pons, Antoni Sureda Gomila, Antoni Tejada Gavela, Silvia |
| author_role | author |
| collection | Repisalud |
| description | Hyperbaric oxygen therapy (HBOT) is the clinical application of oxygen at pressures higher than atmospheric pressure. HBOT has been effectively used to manage diverse clinical pathologies, such as non-healing diabetic ulcers. The aim of the present study was to analyse the effects of HBOT on the plasma oxidative and inflammation biomarkers and growth factors in patients with chronic diabetic wounds. The participants received 20 HBOT sessions (five sessions/week), and blood samples were obtained at sessions 1, 5 and 20, before and 2 h after the HBOT. An additional (control) blood sample was collected 28 days after wound recovery. No significant differences were evident in haematological parameters, whereas the biochemical parameters progressively decreased, which was significant for creatine phosphokinase (CPK) and aspartate aminotransferase (AST). The pro-inflammatory mediators, tumour necrosis factor alpha (TNF-α) and interleukin 1β (IL-1β), progressively decreased throughout the treatments. Biomarkers of oxidative stress--plasma protein levels of catalase, extracellular superoxide dismutase, myeloperoxidase, xanthine oxidase, malondialdehyde (MDA) levels and protein carbonyls--were reduced in accordance with wound healing. Plasma levels of growth factors--platelet-derived growth factor (PDFG), transforming growth factor β (TGF-β) and hypoxia-inducible factor 1-alpha (HIF-1α)-- were increased as a consequence of HBOT and reduced 28 days after complete wound healing, whereas matrix metallopeptidase 9 (MMP9) progressively decreased with the HBOT. In conclusion, HBOT reduced oxidative and pro-inflammatory mediators, and may participate in activating healing, angiogenesis and vascular tone regulation by increasing the release of growth factors. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_fa5b37b07b60bb896ca18eccdae2c9bc |
| institution | Instituto de Salud Carlos III (ISCIII) |
| instname_str | Instituto de Salud Carlos III (ISCIII) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repisalud.isciii.es:20.500.12105/23678 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
| publisherStr | Multidisciplinary Digital Publishing Institute (MDPI) |
| reponame_str | Repisalud |
| spelling | Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds Capó Fiol, Xavier Monserrat-Mesquida, Margalida Quetglas-Llabrés, Magdalena Batle, Juan M Tur, Josep A Pons, Antoni Sureda Gomila, Antoni Tejada Gavela, Silvia Diabetes Mellitus Humanos Biomarcadores Oxigenación Hiperbárica Inflamación Estrés Oxidativo Cicatrización de Heridas Péptidos y Proteínas de Señalización Intercelular Pie Diabético Wound Healing Diabetic Foot Oxidative Stress Biomarkers Humans Intercellular Signaling Peptides and Proteins Inflammation Hyperbaric Oxygenation Hyperbaric oxygen therapy (HBOT) is the clinical application of oxygen at pressures higher than atmospheric pressure. HBOT has been effectively used to manage diverse clinical pathologies, such as non-healing diabetic ulcers. The aim of the present study was to analyse the effects of HBOT on the plasma oxidative and inflammation biomarkers and growth factors in patients with chronic diabetic wounds. The participants received 20 HBOT sessions (five sessions/week), and blood samples were obtained at sessions 1, 5 and 20, before and 2 h after the HBOT. An additional (control) blood sample was collected 28 days after wound recovery. No significant differences were evident in haematological parameters, whereas the biochemical parameters progressively decreased, which was significant for creatine phosphokinase (CPK) and aspartate aminotransferase (AST). The pro-inflammatory mediators, tumour necrosis factor alpha (TNF-α) and interleukin 1β (IL-1β), progressively decreased throughout the treatments. Biomarkers of oxidative stress--plasma protein levels of catalase, extracellular superoxide dismutase, myeloperoxidase, xanthine oxidase, malondialdehyde (MDA) levels and protein carbonyls--were reduced in accordance with wound healing. Plasma levels of growth factors--platelet-derived growth factor (PDFG), transforming growth factor β (TGF-β) and hypoxia-inducible factor 1-alpha (HIF-1α)-- were increased as a consequence of HBOT and reduced 28 days after complete wound healing, whereas matrix metallopeptidase 9 (MMP9) progressively decreased with the HBOT. In conclusion, HBOT reduced oxidative and pro-inflammatory mediators, and may participate in activating healing, angiogenesis and vascular tone regulation by increasing the release of growth factors. Multidisciplinary Digital Publishing Institute (MDPI) https://hdl.handle.net/20.500.12105/23678 |
| spellingShingle | Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds Capó Fiol, Xavier Diabetes Mellitus Humanos Biomarcadores Oxigenación Hiperbárica Inflamación Estrés Oxidativo Cicatrización de Heridas Péptidos y Proteínas de Señalización Intercelular Pie Diabético Wound Healing Diabetic Foot Oxidative Stress Biomarkers Humans Intercellular Signaling Peptides and Proteins Inflammation Hyperbaric Oxygenation |
| title | Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds |
| title_full | Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds |
| title_fullStr | Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds |
| title_full_unstemmed | Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds |
| title_short | Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds |
| title_sort | Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds |
| topic | Diabetes Mellitus Humanos Biomarcadores Oxigenación Hiperbárica Inflamación Estrés Oxidativo Cicatrización de Heridas Péptidos y Proteínas de Señalización Intercelular Pie Diabético Wound Healing Diabetic Foot Oxidative Stress Biomarkers Humans Intercellular Signaling Peptides and Proteins Inflammation Hyperbaric Oxygenation |
| topic_facet | Diabetes Mellitus Humanos Biomarcadores Oxigenación Hiperbárica Inflamación Estrés Oxidativo Cicatrización de Heridas Péptidos y Proteínas de Señalización Intercelular Pie Diabético Wound Healing Diabetic Foot Oxidative Stress Biomarkers Humans Intercellular Signaling Peptides and Proteins Inflammation Hyperbaric Oxygenation |
| url | https://hdl.handle.net/20.500.12105/23678 |