The inhibition of enkephalin catabolism by dual enkephalinase inhibitor: A novel possible therapeutic approach for opioid use disorders
Despite the increasing impact of opioid use disorders on society, there is a disturbing lack of effective medications for their clinical management. An interesting innovative strategy to treat these disorders consists in the protection of endogenous opioid peptides to activate opioid receptors, avoi...
| Authors: | ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2022 |
| Country: | España |
| Institution: | Universitat Pompeu Fabra |
| Repository: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/52218 |
| Online Access: | http://hdl.handle.net/10230/52218 http://dx.doi.org/10.1111/bph.15656 |
| Access Level: | Open access |
| Keyword: | Aminopeptidase N Dual enkephalinase inhibitor Neprilysin Opioid Opioid use disorders δ-opioid receptor μ-opioid receptor |
| _version_ | 1878742678551658496 |
|---|---|
| author | Álvarez-Pérez, Beltrán |
| author2 | Poras, Hervé Maldonado, Rafael, 1961- |
| author2_role | author author |
| author_browse | Maldonado, Rafael, 1961- Poras, Hervé Álvarez-Pérez, Beltrán |
| author_facet | Álvarez-Pérez, Beltrán Poras, Hervé Maldonado, Rafael, 1961- |
| author_role | author |
| collection | Repositorio Digital de la UPF |
| description | Despite the increasing impact of opioid use disorders on society, there is a disturbing lack of effective medications for their clinical management. An interesting innovative strategy to treat these disorders consists in the protection of endogenous opioid peptides to activate opioid receptors, avoiding the classical opioid-like side effects. Dual enkephalinase inhibitors (DENKIs) physiologically activate the endogenous opioid system by inhibiting the enzymes responsible for the breakdown of enkephalins, protecting endogenous enkephalins and increasing their half-lives and physiological actions. The activation of opioid receptors by the increased enkephalin levels, and their well-demonstrated safety, suggests that DENKIs could represent a novel analgesic therapy and a possible effective treatment for acute opioid withdrawal, as well as a promising alternative to opioid substitution therapy minimizing side effects. This new pharmacological class of compounds could bring effective and safe medications avoiding the major limitations of exogenous opioids, representing a novel approach to overcome the problem of opioid use disorders. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_fa48df03ddcbefc7278cddfebbebcd90 |
| institution | Universitat Pompeu Fabra |
| instname_str | Universitat Pompeu Fabra |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositori.upf.edu:10230/52218 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher | Wiley |
| publisherStr | Wiley |
| reponame_str | Repositorio Digital de la UPF |
| spelling | The inhibition of enkephalin catabolism by dual enkephalinase inhibitor: A novel possible therapeutic approach for opioid use disorders Álvarez-Pérez, Beltrán Poras, Hervé Maldonado, Rafael, 1961- Aminopeptidase N Dual enkephalinase inhibitor Neprilysin Opioid Opioid use disorders δ-opioid receptor μ-opioid receptor Despite the increasing impact of opioid use disorders on society, there is a disturbing lack of effective medications for their clinical management. An interesting innovative strategy to treat these disorders consists in the protection of endogenous opioid peptides to activate opioid receptors, avoiding the classical opioid-like side effects. Dual enkephalinase inhibitors (DENKIs) physiologically activate the endogenous opioid system by inhibiting the enzymes responsible for the breakdown of enkephalins, protecting endogenous enkephalins and increasing their half-lives and physiological actions. The activation of opioid receptors by the increased enkephalin levels, and their well-demonstrated safety, suggests that DENKIs could represent a novel analgesic therapy and a possible effective treatment for acute opioid withdrawal, as well as a promising alternative to opioid substitution therapy minimizing side effects. This new pharmacological class of compounds could bring effective and safe medications avoiding the major limitations of exogenous opioids, representing a novel approach to overcome the problem of opioid use disorders. Wiley http://hdl.handle.net/10230/52218 http://dx.doi.org/10.1111/bph.15656 |
| spellingShingle | The inhibition of enkephalin catabolism by dual enkephalinase inhibitor: A novel possible therapeutic approach for opioid use disorders Álvarez-Pérez, Beltrán Aminopeptidase N Dual enkephalinase inhibitor Neprilysin Opioid Opioid use disorders δ-opioid receptor μ-opioid receptor |
| status_str | publishedVersion |
| title | The inhibition of enkephalin catabolism by dual enkephalinase inhibitor: A novel possible therapeutic approach for opioid use disorders |
| title_full | The inhibition of enkephalin catabolism by dual enkephalinase inhibitor: A novel possible therapeutic approach for opioid use disorders |
| title_fullStr | The inhibition of enkephalin catabolism by dual enkephalinase inhibitor: A novel possible therapeutic approach for opioid use disorders |
| title_full_unstemmed | The inhibition of enkephalin catabolism by dual enkephalinase inhibitor: A novel possible therapeutic approach for opioid use disorders |
| title_short | The inhibition of enkephalin catabolism by dual enkephalinase inhibitor: A novel possible therapeutic approach for opioid use disorders |
| title_sort | The inhibition of enkephalin catabolism by dual enkephalinase inhibitor: A novel possible therapeutic approach for opioid use disorders |
| topic | Aminopeptidase N Dual enkephalinase inhibitor Neprilysin Opioid Opioid use disorders δ-opioid receptor μ-opioid receptor |
| topic_facet | Aminopeptidase N Dual enkephalinase inhibitor Neprilysin Opioid Opioid use disorders δ-opioid receptor μ-opioid receptor |
| url | http://hdl.handle.net/10230/52218 http://dx.doi.org/10.1111/bph.15656 |