Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness.
The high prevalence of comorbidity between bipolar disorder (BD) and other medical conditions, including autoimmune diseases, supports the hypothesis of the nature of BD as a biological illness category. Hence, an immune dysregulation process may play an important role in the development of at least...
| Authors: | ; ; ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Accepted version |
| Publication date: | 2015 |
| Country: | España |
| Institution: | Universitat Pompeu Fabra |
| Repository: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/25110 |
| Online Access: | http://hdl.handle.net/10230/25110 http://dx.doi.org/10.1016/j.neubiorev.2015.05.012 |
| Access Level: | Open access |
| Keyword: | Psicosi maniacodepressiva Autoimmunitat Depressió psíquica |
| _version_ | 1878742674715967488 |
|---|---|
| author | León Caballero, Jordi |
| author2 | Pacchiarotti, Isabella Murru, Andrea Valentí, M. Colom, Francesc Benach, B. Pérez Solà, Víctor Dalmau, Josep Vieta, Eduard |
| author2_role | author author author author author author author author |
| author_browse | Benach, B. Colom, Francesc Dalmau, Josep León Caballero, Jordi Murru, Andrea Pacchiarotti, Isabella Pérez Solà, Víctor Valentí, M. Vieta, Eduard |
| author_facet | León Caballero, Jordi Pacchiarotti, Isabella Murru, Andrea Valentí, M. Colom, Francesc Benach, B. Pérez Solà, Víctor Dalmau, Josep Vieta, Eduard |
| author_role | author |
| collection | Repositorio Digital de la UPF |
| description | The high prevalence of comorbidity between bipolar disorder (BD) and other medical conditions, including autoimmune diseases, supports the hypothesis of the nature of BD as a biological illness category. Hence, an immune dysregulation process may play an important role in the development of at least certain subtypes of BD. Increasing evidence also suggests that the N-methyl-d-aspartate receptor (NMDAR) may be relevant in the pathophysiology of BD. A possible key mechanism underlying the physiopathology of certain autoimmune diseases that may present with affective symptoms might be the production of anti-NMDAR auto-antibodies (auto-Abs). The best characterized autoimmune anti-NMDAR disease is the anti-NMDAR encephalitis. It has been found that 4% of these patients present isolated, mostly affective, psychiatric manifestations during their illness. An interesting suggestion emerged from this overview is that the same mechanisms that trigger affective symptoms in patients with increased anti-NMDAR auto-Abs levels could be involved in the physiopathology of at least a subgroup of BD. Future studies are needed to characterize the relationship between anti-NMDAR auto-Abs and BD. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_fa3cd2cf4780512a08d98a05bc83f802 |
| institution | Universitat Pompeu Fabra |
| instname_str | Universitat Pompeu Fabra |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositori.upf.edu:10230/25110 |
| publishDate | 2015 |
| publishDateSort | 2015 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| reponame_str | Repositorio Digital de la UPF |
| spelling | Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness. León Caballero, Jordi Pacchiarotti, Isabella Murru, Andrea Valentí, M. Colom, Francesc Benach, B. Pérez Solà, Víctor Dalmau, Josep Vieta, Eduard Psicosi maniacodepressiva Autoimmunitat Depressió psíquica The high prevalence of comorbidity between bipolar disorder (BD) and other medical conditions, including autoimmune diseases, supports the hypothesis of the nature of BD as a biological illness category. Hence, an immune dysregulation process may play an important role in the development of at least certain subtypes of BD. Increasing evidence also suggests that the N-methyl-d-aspartate receptor (NMDAR) may be relevant in the pathophysiology of BD. A possible key mechanism underlying the physiopathology of certain autoimmune diseases that may present with affective symptoms might be the production of anti-NMDAR auto-antibodies (auto-Abs). The best characterized autoimmune anti-NMDAR disease is the anti-NMDAR encephalitis. It has been found that 4% of these patients present isolated, mostly affective, psychiatric manifestations during their illness. An interesting suggestion emerged from this overview is that the same mechanisms that trigger affective symptoms in patients with increased anti-NMDAR auto-Abs levels could be involved in the physiopathology of at least a subgroup of BD. Future studies are needed to characterize the relationship between anti-NMDAR auto-Abs and BD. The authors ofthis report wouldlike to acknowledge the support of the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III (CP08/00140 and PI 12/00910), CIBERSAM (Exp. CB07/ 09/0004), the Spanish Ministry of Education and the Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya to the Bipolar Disorders Group (2014 SGR 398). Elsevier http://hdl.handle.net/10230/25110 http://dx.doi.org/10.1016/j.neubiorev.2015.05.012 |
| spellingShingle | Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness. León Caballero, Jordi Psicosi maniacodepressiva Autoimmunitat Depressió psíquica |
| status_str | acceptedVersion |
| title | Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness. |
| title_full | Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness. |
| title_fullStr | Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness. |
| title_full_unstemmed | Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness. |
| title_short | Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness. |
| title_sort | Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness. |
| topic | Psicosi maniacodepressiva Autoimmunitat Depressió psíquica |
| topic_facet | Psicosi maniacodepressiva Autoimmunitat Depressió psíquica |
| url | http://hdl.handle.net/10230/25110 http://dx.doi.org/10.1016/j.neubiorev.2015.05.012 |