Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study
Background Rapid drug desensitization (RDD) allows first-line treatment to continue after a hypersensitivity reaction to the antineoplastic agent. There are different desensitization procedures, and none of them are free from breakthrough reactions (BTR).Objectives The objective of the study is to e...
| Authors: | ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2026 |
| Country: | España |
| Institution: | Universidad de Málaga |
| Repository: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:dnet:r-fisabio___::165370c97d3f65d9e954062969a78826 |
| Online Access: | https://fisabio.portalinvestigacion.com/publicaciones/20548 |
| Access Level: | Open access |
| Keyword: | antineoplastic agents breakthrough reactions chemotherapy rapid drug desensitization same day desensitization |
| _version_ | 1878742477933903872 |
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| author | Górriz, MCT |
| author2 | Cuartero, JB Ayllón, PV Hernández, AS Hernández, CV Viciano, IG Enrique, E |
| author2_role | author author author author author author |
| author_browse | Ayllón, PV Cuartero, JB Enrique, E Górriz, MCT Hernández, AS Hernández, CV Viciano, IG |
| author_facet | Górriz, MCT Cuartero, JB Ayllón, PV Hernández, AS Hernández, CV Viciano, IG Enrique, E |
| author_role | author |
| collection | r-FISABIO. Repositorio Institucional de Producción Científica |
| description | Background Rapid drug desensitization (RDD) allows first-line treatment to continue after a hypersensitivity reaction to the antineoplastic agent. There are different desensitization procedures, and none of them are free from breakthrough reactions (BTR).Objectives The objective of the study is to evaluate and compare the efficacy of different desensitization procedures, considering the effect of a series of confounding variables, and to describe the characteristics of BTRs in different procedures.Methods A retrospective, comparative review of medical records from patients who experienced hypersensitivity reactions to platinum- or taxane-based chemotherapy was conducted. Patients were categorized into two groups; rapid drug desensitization (RDD) and same-day desensitization (SDD), according to the intervention performed on the day of the initial reaction. Demographic data, drug, retreatment, cancer type, phenotype and severity of the initial reaction, allergy testing, number of desensitizations performed, outcome of desensitizations, and number, phenotype and severity of BTRs were recorded according to group.Results In the RDD group, 406 desensitizations were analyzed in 76 subjects with a BTR rate of 24%. In the SDD group, 164 desensitizations were analyzed in 44 subjects with a BTR rate of 15%. A marginaleffects analysis using a Bayesian hierarchical model showed a 14.6-point reduction in the probability of BTR in the SDD group.Conclusion This study confirms that desensitization procedures are safe and effective and allows us to conclude, based on the data and the model, that the SDD group has a lower probability of BTR than the RDD group. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_f6a010b1f6f9a1b00625f593ac4e65c8 |
| institution | Universidad de Málaga |
| instname_str | Universidad de Málaga |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:dnet:r-fisabio___::165370c97d3f65d9e954062969a78826 |
| publishDate | 2026 |
| publishDateSort | 2026 |
| publisher | FRONTIERS MEDIA SA |
| publisherStr | FRONTIERS MEDIA SA |
| reponame_str | r-FISABIO. Repositorio Institucional de Producción Científica |
| spelling | Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study Górriz, MCT Cuartero, JB Ayllón, PV Hernández, AS Hernández, CV Viciano, IG Enrique, E antineoplastic agents breakthrough reactions chemotherapy rapid drug desensitization same day desensitization Background Rapid drug desensitization (RDD) allows first-line treatment to continue after a hypersensitivity reaction to the antineoplastic agent. There are different desensitization procedures, and none of them are free from breakthrough reactions (BTR).Objectives The objective of the study is to evaluate and compare the efficacy of different desensitization procedures, considering the effect of a series of confounding variables, and to describe the characteristics of BTRs in different procedures.Methods A retrospective, comparative review of medical records from patients who experienced hypersensitivity reactions to platinum- or taxane-based chemotherapy was conducted. Patients were categorized into two groups; rapid drug desensitization (RDD) and same-day desensitization (SDD), according to the intervention performed on the day of the initial reaction. Demographic data, drug, retreatment, cancer type, phenotype and severity of the initial reaction, allergy testing, number of desensitizations performed, outcome of desensitizations, and number, phenotype and severity of BTRs were recorded according to group.Results In the RDD group, 406 desensitizations were analyzed in 76 subjects with a BTR rate of 24%. In the SDD group, 164 desensitizations were analyzed in 44 subjects with a BTR rate of 15%. A marginaleffects analysis using a Bayesian hierarchical model showed a 14.6-point reduction in the probability of BTR in the SDD group.Conclusion This study confirms that desensitization procedures are safe and effective and allows us to conclude, based on the data and the model, that the SDD group has a lower probability of BTR than the RDD group. FRONTIERS MEDIA SA https://fisabio.portalinvestigacion.com/publicaciones/20548 |
| spellingShingle | Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study Górriz, MCT antineoplastic agents breakthrough reactions chemotherapy rapid drug desensitization same day desensitization |
| status_str | publishedVersion |
| title | Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study |
| title_full | Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study |
| title_fullStr | Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study |
| title_full_unstemmed | Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study |
| title_short | Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study |
| title_sort | Comparison of rapid and same-day desensitization protocols in hypersensitivity reactions to platinum and taxanes: a retrospective cohort study |
| topic | antineoplastic agents breakthrough reactions chemotherapy rapid drug desensitization same day desensitization |
| topic_facet | antineoplastic agents breakthrough reactions chemotherapy rapid drug desensitization same day desensitization |
| url | https://fisabio.portalinvestigacion.com/publicaciones/20548 |