Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children...
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| Tipo de documento: | Artigo |
| Data de publicação: | 2024 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositório: | Dipòsit Digital de Documents de la UAB |
| Idioma: | Inglês |
| OAI Identifier: | oai:ddd.uab.cat:317410 |
| Acesso em linha: | https://ddd.uab.cat/record/317410 https://dx.doi.org/urn:doi:10.1084/jem.20231353 |
| Nível de acesso: | Acesso aberto |
| _version_ | 1878742393851740160 |
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| author | Bastard, Paul|||0000-0002-5926-8437 |
| author2 | Gervais, A. Taniguchi, M. Saare, L. Särekannu, K. Voyer, T.L. Philippot, Q. Rosain, J. Bizien, L. Asano, T. Garcia-Prat, Marina|||0000-0001-5387-1908 Parra-Martínez, Alba|||0000-0002-9564-8912 Migaud, M. Tsumura, M. Conti, F. Belot, Alexandre|||0000-0003-4902-5332 Rivière, Jacques G.|||0000-0003-1055-2063 Morio, T. Tanaka, J. Javouhey, E. Haerynck, F. Duvlis, S. Ozcelik, Tayfun|||0000-0001-5937-1082 Keles, S. Tandjaoui-Lambiotte, Y. Escoda, S. Husain, M. Pan-Hammarström, Q. Hammarström, L. Ahlijah, G. Haidar, A.A. Soudee, C. Arseguel, V. Abolhassani, Hassan|||0000-0002-4838-0407 Sahanic, S. Tancevski, I. Nukui, Y. Hayakawa, S. Chrousos, G.P. Michos, A. Tatsi, E.B. Filippatos, F. Rodriguez-Palmero, A. Troya, Jesús|||0000-0001-7323-114X Tipu, I. Meyts, I. Roussel, L. Ostrowski, S.R. Schidlowski, L. Prando, C. Condino-Neto, Antonio|||0000-0002-1069-3117 Cheikh, N. Bousfiha, A.A. Bakkouri, J.E. Peterson, P. Pujol, Aurora|||0000-0002-9606-0600 Lévy, R. Quartier, P. Vinh, D.C. Boisson, Bertrand|||0000-0001-5240-3555 Béziat, V. Zhang, S.Y. Borghesi, A. Pession, A. Andreakos, E. Marr, N. Mentis, A.F.A. H.mogensen, T. Rodríguez-Gallego, C. Colobrán Oriol, Roger|||0000-0002-5964-536X Tillmann, V. Neven, B. Trouillet-Assant, S. Brodin, P. Abel, Laurent|||0000-0001-7016-6493 Jouanguy, Emmanuelle|||0000-0002-7358-9157 Zhang, Q. Martinón Torres, Federico|||0000-0002-9023-581X Salas, A. Gómez-Carballa, A. Gonzalez-Granado, L.I. Kisand, K. Okada, S. Puel, A. Cobat, Aurélie|||0000-0001-7209-6257 Casanova, Jean-Laurent|||0000-0002-7782-4169 Aguilera-Albesa, Sergio|||0000-0003-3540-1448 AlKhater, Suzan|||0000-0001-7315-6581 Alkan, G. Castagnoli, R. Cyrus, C.|||0000-0001-7333-6486 Bozdemir, S.E. Emiroglu, M. Gulhan, Belgin|||0000-0003-0839-1301 Erdeniz, E.H. Hatipoglu, N. Bayhan, G.I.|||0000-0002-1423-4348 Jabandziev, P. Yuksek, S.K. Karbuz, A. Öz, Ş.K.T. Marseglia, G.L. Akcan, O.M. Kılıç, A.O. Parlakay, A.O. Papadaki, M. Slaba, K. Sevketoglu, Esra|||0000-0002-8330-2877 Valencia-Ramos, J. Yahşi, A. Tuala, C. Urbieta, A.I.D. Esteban, B.D. Santalla, M.J.D. Pérez, C.F. Villaverde, J.F. Rodríguez, C.G. Allut, J.L.G. Vicente, L.G. Vázquez, E.G. Carballa, A.G. Rial, J.G. Barcala, F.J.G. Liñares, B.G. Iglesias, P.L. Massa, B.L. Fuentes, M.L. Franco, M.L. Lago, A.L. Cruz, D.N.D.l Masid, E.N. Devesa, J.B.O. Seco, J.P. Núñez, M.P. Bernal, M.P.D.M. Freixo, H.P. Rodríguez, L.P. Pischedda, S. Romero, M.P. Reino, A.P. Hervella, G.M.P. Verdes, T.Q. Redondo Collazo, Lorenzo|||0000-0002-3521-678X Casuso, P.R. García, S.R. Vázquez, S.R. Blanco, V.R. Calle, I.R. Velasco, C.R. Núñez, N.R. Sánchez, C.R.T. Paz, E.S. Orayyou, J.M.S. Villanueva, C.S. Fernández, S.S. Sanmartín, P.S. Muñiz, M.T. Pena, R.T. Castellano, M.T. Cuadrado, L.V. García, P.V. Iglesias, M.S.V. Lasheras, S.V. Ferreiro Iglesias, Rocío|||0000-0002-0469-4332 Bastón-Rey, I. Calviño-Suárez, C. Aiuti, Alessandro|||0000-0002-5398-1717 Al-Muhsen, S. Al-Mulla, F. Amara, A. Anderson, M.S. Arias, A.A. Arkin, L.M. Feldman, H.B. Biggs, C.M. Bogunovic, Dusan|||0000-0002-9277-3232 Bolze, Alexandre|||0000-0001-7399-2766 Bondarenko, A.|||0000-0002-9737-2868 Bryceson, Y. Butte, M.J. Casari, G. Christodoulou, J. Constantinescu, S.N. Cooper, M.A. Dalgard, C.L. Desai, M. Drolet, B.A. Duval, X. Baghdadi, J.E. Eloy, P. Espinosa-Padilla, S. Fellay, Jacques|||0000-0002-8240-939X Flores, Carlos|||0000-0001-5352-069X Franco, J.L. Froidure, A. Gorochov, G. Gregersen, P.K. Grimbacher, B. Hagin, D. Halwani, R. Heath, J.R. Hsieh, E.W.Y. Husebye, Eystein Sverre|||0000-0002-7886-2976 Imai, K. Itan, Yuval Jarvis, E.D. Kaja, E. Karamitros, T. Ku, C.L. Lau, Y.L. Ling, Y. Lucas, C.L. Mansouri, D. Maródi, L. Mentré, F. Milner, J.D. Mironska, K. Mogensen, T.H. Ng, L.F.P. Notarangelo, L.D. Novelli, A. Novelli, G. O'Farrelly, C. Okamoto, K. Pape, J.W. Perez de Diego, Rebeca|||0000-0001-8426-8765 Perez-Tur, J. Perlin, D.S. Pesole, G. Planas, A.M. Quintana-Murci, L. Ramaswamy, S. Renia, L. Resnick, I. Sancho-Shimizu, V. Sediva, A. Seppänen, M.R.J. Shahrooei, M. Shcherbina, A. Slaby, O. Snow, A.L. Soler-Palacín, Pere|||0000-0002-0346-5570 Soumelis, V. Spaan, A.N. Su, H.C. Tangye, S.G. Tayoun, A.A. Temel, Ş.G. Thorball, C. Tiberghien, P. Turvey, S.E. Uddin, K.M.F. Uddin, M.J. Beek, D.v.d Bernuth, H.v Wauters, J. Zatz, Mayana|||0000-0003-3970-8025 Zawadzki, Pawel |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Abel, Laurent|||0000-0001-7016-6493 Abolhassani, Hassan|||0000-0002-4838-0407 Aguilera-Albesa, Sergio|||0000-0003-3540-1448 Ahlijah, G. Aiuti, Alessandro|||0000-0002-5398-1717 Akcan, O.M. Al-Muhsen, S. Al-Mulla, F. AlKhater, Suzan|||0000-0001-7315-6581 Alkan, G. Allut, J.L.G. Amara, A. Anderson, M.S. Andreakos, E. Arias, A.A. Arkin, L.M. Arseguel, V. Asano, T. Baghdadi, J.E. Bakkouri, J.E. Barcala, F.J.G. Bastard, Paul|||0000-0002-5926-8437 Bastón-Rey, I. Bayhan, G.I.|||0000-0002-1423-4348 Beek, D.v.d Belot, Alexandre|||0000-0003-4902-5332 Bernal, M.P.D.M. Bernuth, H.v Biggs, C.M. Bizien, L. Blanco, V.R. Bogunovic, Dusan|||0000-0002-9277-3232 Boisson, Bertrand|||0000-0001-5240-3555 Bolze, Alexandre|||0000-0001-7399-2766 Bondarenko, A.|||0000-0002-9737-2868 Borghesi, A. Bousfiha, A.A. Bozdemir, S.E. Brodin, P. Bryceson, Y. Butte, M.J. Béziat, V. Calle, I.R. Calviño-Suárez, C. Carballa, A.G. Casanova, Jean-Laurent|||0000-0002-7782-4169 Casari, G. Castagnoli, R. Castellano, M.T. Casuso, P.R. Cheikh, N. Christodoulou, J. Chrousos, G.P. Cobat, Aurélie|||0000-0001-7209-6257 Colobrán Oriol, Roger|||0000-0002-5964-536X Condino-Neto, Antonio|||0000-0002-1069-3117 Constantinescu, S.N. Conti, F. Cooper, M.A. Cruz, D.N.D.l Cuadrado, L.V. Cyrus, C.|||0000-0001-7333-6486 Dalgard, C.L. Desai, M. Devesa, J.B.O. Drolet, B.A. Duval, X. Duvlis, S. Eloy, P. Emiroglu, M. Erdeniz, E.H. Escoda, S. Espinosa-Padilla, S. Esteban, B.D. Feldman, H.B. Fellay, Jacques|||0000-0002-8240-939X Fernández, S.S. Ferreiro Iglesias, Rocío|||0000-0002-0469-4332 Filippatos, F. Flores, Carlos|||0000-0001-5352-069X Franco, J.L. Franco, M.L. Freixo, H.P. Froidure, A. Fuentes, M.L. Garcia-Prat, Marina|||0000-0001-5387-1908 García, P.V. García, S.R. Gervais, A. Gonzalez-Granado, L.I. Gorochov, G. Gregersen, P.K. Grimbacher, B. Gulhan, Belgin|||0000-0003-0839-1301 Gómez-Carballa, A. H.mogensen, T. Haerynck, F. Hagin, D. Haidar, A.A. Halwani, R. Hammarström, L. Hatipoglu, N. Hayakawa, S. Heath, J.R. Hervella, G.M.P. Hsieh, E.W.Y. Husain, M. Husebye, Eystein Sverre|||0000-0002-7886-2976 Iglesias, M.S.V. Iglesias, P.L. Imai, K. Itan, Yuval Jabandziev, P. Jarvis, E.D. Javouhey, E. Jouanguy, Emmanuelle|||0000-0002-7358-9157 Kaja, E. Karamitros, T. Karbuz, A. Keles, S. Kisand, K. Ku, C.L. Kılıç, A.O. Lago, A.L. Lasheras, S.V. Lau, Y.L. Ling, Y. Liñares, B.G. Lucas, C.L. Lévy, R. Mansouri, D. Marr, N. Marseglia, G.L. Martinón Torres, Federico|||0000-0002-9023-581X Maródi, L. Masid, E.N. Massa, B.L. Mentis, A.F.A. Mentré, F. Meyts, I. Michos, A. Migaud, M. Milner, J.D. Mironska, K. Mogensen, T.H. Morio, T. Muñiz, M.T. Neven, B. Ng, L.F.P. Notarangelo, L.D. Novelli, A. Novelli, G. Nukui, Y. Núñez, M.P. Núñez, N.R. O'Farrelly, C. Okada, S. Okamoto, K. Orayyou, J.M.S. Ostrowski, S.R. Ozcelik, Tayfun|||0000-0001-5937-1082 Pan-Hammarström, Q. Papadaki, M. Pape, J.W. Parlakay, A.O. Parra-Martínez, Alba|||0000-0002-9564-8912 Paz, E.S. Pena, R.T. Perez de Diego, Rebeca|||0000-0001-8426-8765 Perez-Tur, J. Perlin, D.S. Pesole, G. Pession, A. Peterson, P. Philippot, Q. Pischedda, S. Planas, A.M. Prando, C. Puel, A. Pujol, Aurora|||0000-0002-9606-0600 Pérez, C.F. Quartier, P. Quintana-Murci, L. Ramaswamy, S. Redondo Collazo, Lorenzo|||0000-0002-3521-678X Reino, A.P. Renia, L. Resnick, I. Rial, J.G. Rivière, Jacques G.|||0000-0003-1055-2063 Rodriguez-Palmero, A. Rodríguez, C.G. Rodríguez, L.P. Rodríguez-Gallego, C. Romero, M.P. Rosain, J. Roussel, L. Saare, L. Sahanic, S. Salas, A. Sancho-Shimizu, V. Sanmartín, P.S. Santalla, M.J.D. Schidlowski, L. Seco, J.P. Sediva, A. Seppänen, M.R.J. Sevketoglu, Esra|||0000-0002-8330-2877 Shahrooei, M. Shcherbina, A. Slaba, K. Slaby, O. Snow, A.L. Soler-Palacín, Pere|||0000-0002-0346-5570 Soudee, C. Soumelis, V. Spaan, A.N. Su, H.C. Sánchez, C.R.T. Särekannu, K. Tanaka, J. Tancevski, I. Tandjaoui-Lambiotte, Y. Tangye, S.G. Taniguchi, M. Tatsi, E.B. Tayoun, A.A. Temel, Ş.G. Thorball, C. Tiberghien, P. Tillmann, V. Tipu, I. Trouillet-Assant, S. Troya, Jesús|||0000-0001-7323-114X Tsumura, M. Tuala, C. Turvey, S.E. Uddin, K.M.F. Uddin, M.J. Urbieta, A.I.D. Valencia-Ramos, J. Velasco, C.R. Verdes, T.Q. Vicente, L.G. Villanueva, C.S. Villaverde, J.F. Vinh, D.C. Voyer, T.L. Vázquez, E.G. Vázquez, S.R. Wauters, J. Yahşi, A. Yuksek, S.K. Zatz, Mayana|||0000-0003-3970-8025 Zawadzki, Pawel Zhang, Q. Zhang, S.Y. Öz, Ş.K.T. |
| author_facet | Bastard, Paul|||0000-0002-5926-8437 Gervais, A. Taniguchi, M. Saare, L. Särekannu, K. Voyer, T.L. Philippot, Q. Rosain, J. Bizien, L. Asano, T. Garcia-Prat, Marina|||0000-0001-5387-1908 Parra-Martínez, Alba|||0000-0002-9564-8912 Migaud, M. Tsumura, M. Conti, F. Belot, Alexandre|||0000-0003-4902-5332 Rivière, Jacques G.|||0000-0003-1055-2063 Morio, T. Tanaka, J. Javouhey, E. Haerynck, F. Duvlis, S. Ozcelik, Tayfun|||0000-0001-5937-1082 Keles, S. Tandjaoui-Lambiotte, Y. Escoda, S. Husain, M. Pan-Hammarström, Q. Hammarström, L. Ahlijah, G. Haidar, A.A. Soudee, C. Arseguel, V. Abolhassani, Hassan|||0000-0002-4838-0407 Sahanic, S. Tancevski, I. Nukui, Y. Hayakawa, S. Chrousos, G.P. Michos, A. Tatsi, E.B. Filippatos, F. Rodriguez-Palmero, A. Troya, Jesús|||0000-0001-7323-114X Tipu, I. Meyts, I. Roussel, L. Ostrowski, S.R. Schidlowski, L. Prando, C. Condino-Neto, Antonio|||0000-0002-1069-3117 Cheikh, N. Bousfiha, A.A. Bakkouri, J.E. Peterson, P. Pujol, Aurora|||0000-0002-9606-0600 Lévy, R. Quartier, P. Vinh, D.C. Boisson, Bertrand|||0000-0001-5240-3555 Béziat, V. Zhang, S.Y. Borghesi, A. Pession, A. Andreakos, E. Marr, N. Mentis, A.F.A. H.mogensen, T. Rodríguez-Gallego, C. Colobrán Oriol, Roger|||0000-0002-5964-536X Tillmann, V. Neven, B. Trouillet-Assant, S. Brodin, P. Abel, Laurent|||0000-0001-7016-6493 Jouanguy, Emmanuelle|||0000-0002-7358-9157 Zhang, Q. Martinón Torres, Federico|||0000-0002-9023-581X Salas, A. Gómez-Carballa, A. Gonzalez-Granado, L.I. Kisand, K. Okada, S. Puel, A. Cobat, Aurélie|||0000-0001-7209-6257 Casanova, Jean-Laurent|||0000-0002-7782-4169 Aguilera-Albesa, Sergio|||0000-0003-3540-1448 AlKhater, Suzan|||0000-0001-7315-6581 Alkan, G. Castagnoli, R. Cyrus, C.|||0000-0001-7333-6486 Bozdemir, S.E. Emiroglu, M. Gulhan, Belgin|||0000-0003-0839-1301 Erdeniz, E.H. Hatipoglu, N. Bayhan, G.I.|||0000-0002-1423-4348 Jabandziev, P. Yuksek, S.K. Karbuz, A. Öz, Ş.K.T. Marseglia, G.L. Akcan, O.M. Kılıç, A.O. Parlakay, A.O. Papadaki, M. Slaba, K. Sevketoglu, Esra|||0000-0002-8330-2877 Valencia-Ramos, J. Yahşi, A. Tuala, C. Urbieta, A.I.D. Esteban, B.D. Santalla, M.J.D. Pérez, C.F. Villaverde, J.F. Rodríguez, C.G. Allut, J.L.G. Vicente, L.G. Vázquez, E.G. Carballa, A.G. Rial, J.G. Barcala, F.J.G. Liñares, B.G. Iglesias, P.L. Massa, B.L. Fuentes, M.L. Franco, M.L. Lago, A.L. Cruz, D.N.D.l Masid, E.N. Devesa, J.B.O. Seco, J.P. Núñez, M.P. Bernal, M.P.D.M. Freixo, H.P. Rodríguez, L.P. Pischedda, S. Romero, M.P. Reino, A.P. Hervella, G.M.P. Verdes, T.Q. Redondo Collazo, Lorenzo|||0000-0002-3521-678X Casuso, P.R. García, S.R. Vázquez, S.R. Blanco, V.R. Calle, I.R. Velasco, C.R. Núñez, N.R. Sánchez, C.R.T. Paz, E.S. Orayyou, J.M.S. Villanueva, C.S. Fernández, S.S. Sanmartín, P.S. Muñiz, M.T. Pena, R.T. Castellano, M.T. Cuadrado, L.V. García, P.V. Iglesias, M.S.V. Lasheras, S.V. Ferreiro Iglesias, Rocío|||0000-0002-0469-4332 Bastón-Rey, I. Calviño-Suárez, C. Aiuti, Alessandro|||0000-0002-5398-1717 Al-Muhsen, S. Al-Mulla, F. Amara, A. Anderson, M.S. Arias, A.A. Arkin, L.M. Feldman, H.B. Biggs, C.M. Bogunovic, Dusan|||0000-0002-9277-3232 Bolze, Alexandre|||0000-0001-7399-2766 Bondarenko, A.|||0000-0002-9737-2868 Bryceson, Y. Butte, M.J. Casari, G. Christodoulou, J. Constantinescu, S.N. Cooper, M.A. Dalgard, C.L. Desai, M. Drolet, B.A. Duval, X. Baghdadi, J.E. Eloy, P. Espinosa-Padilla, S. Fellay, Jacques|||0000-0002-8240-939X Flores, Carlos|||0000-0001-5352-069X Franco, J.L. Froidure, A. Gorochov, G. Gregersen, P.K. Grimbacher, B. Hagin, D. Halwani, R. Heath, J.R. Hsieh, E.W.Y. Husebye, Eystein Sverre|||0000-0002-7886-2976 Imai, K. Itan, Yuval Jarvis, E.D. Kaja, E. Karamitros, T. Ku, C.L. Lau, Y.L. Ling, Y. Lucas, C.L. Mansouri, D. Maródi, L. Mentré, F. Milner, J.D. Mironska, K. Mogensen, T.H. Ng, L.F.P. Notarangelo, L.D. Novelli, A. Novelli, G. O'Farrelly, C. Okamoto, K. Pape, J.W. Perez de Diego, Rebeca|||0000-0001-8426-8765 Perez-Tur, J. Perlin, D.S. Pesole, G. Planas, A.M. Quintana-Murci, L. Ramaswamy, S. Renia, L. Resnick, I. Sancho-Shimizu, V. Sediva, A. Seppänen, M.R.J. Shahrooei, M. Shcherbina, A. Slaby, O. Snow, A.L. Soler-Palacín, Pere|||0000-0002-0346-5570 Soumelis, V. Spaan, A.N. Su, H.C. Tangye, S.G. Tayoun, A.A. Temel, Ş.G. Thorball, C. Tiberghien, P. Turvey, S.E. Uddin, K.M.F. Uddin, M.J. Beek, D.v.d Bernuth, H.v Wauters, J. Zatz, Mayana|||0000-0003-3970-8025 Zawadzki, Pawel |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_f5220f7b584e29fb3be7861165f3a4e3 |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:317410 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children Bastard, Paul|||0000-0002-5926-8437 Gervais, A. Taniguchi, M. Saare, L. Särekannu, K. Voyer, T.L. Philippot, Q. Rosain, J. Bizien, L. Asano, T. Garcia-Prat, Marina|||0000-0001-5387-1908 Parra-Martínez, Alba|||0000-0002-9564-8912 Migaud, M. Tsumura, M. Conti, F. Belot, Alexandre|||0000-0003-4902-5332 Rivière, Jacques G.|||0000-0003-1055-2063 Morio, T. Tanaka, J. Javouhey, E. Haerynck, F. Duvlis, S. Ozcelik, Tayfun|||0000-0001-5937-1082 Keles, S. Tandjaoui-Lambiotte, Y. Escoda, S. Husain, M. Pan-Hammarström, Q. Hammarström, L. Ahlijah, G. Haidar, A.A. Soudee, C. Arseguel, V. Abolhassani, Hassan|||0000-0002-4838-0407 Sahanic, S. Tancevski, I. Nukui, Y. Hayakawa, S. Chrousos, G.P. Michos, A. Tatsi, E.B. Filippatos, F. Rodriguez-Palmero, A. Troya, Jesús|||0000-0001-7323-114X Tipu, I. Meyts, I. Roussel, L. Ostrowski, S.R. Schidlowski, L. Prando, C. Condino-Neto, Antonio|||0000-0002-1069-3117 Cheikh, N. Bousfiha, A.A. Bakkouri, J.E. Peterson, P. Pujol, Aurora|||0000-0002-9606-0600 Lévy, R. Quartier, P. Vinh, D.C. Boisson, Bertrand|||0000-0001-5240-3555 Béziat, V. Zhang, S.Y. Borghesi, A. Pession, A. Andreakos, E. Marr, N. Mentis, A.F.A. H.mogensen, T. Rodríguez-Gallego, C. Colobrán Oriol, Roger|||0000-0002-5964-536X Tillmann, V. Neven, B. Trouillet-Assant, S. Brodin, P. Abel, Laurent|||0000-0001-7016-6493 Jouanguy, Emmanuelle|||0000-0002-7358-9157 Zhang, Q. Martinón Torres, Federico|||0000-0002-9023-581X Salas, A. Gómez-Carballa, A. Gonzalez-Granado, L.I. Kisand, K. Okada, S. Puel, A. Cobat, Aurélie|||0000-0001-7209-6257 Casanova, Jean-Laurent|||0000-0002-7782-4169 Aguilera-Albesa, Sergio|||0000-0003-3540-1448 AlKhater, Suzan|||0000-0001-7315-6581 Alkan, G. Castagnoli, R. Cyrus, C.|||0000-0001-7333-6486 Bozdemir, S.E. Emiroglu, M. Gulhan, Belgin|||0000-0003-0839-1301 Erdeniz, E.H. Hatipoglu, N. Bayhan, G.I.|||0000-0002-1423-4348 Jabandziev, P. Yuksek, S.K. Karbuz, A. Öz, Ş.K.T. Marseglia, G.L. Akcan, O.M. Kılıç, A.O. Parlakay, A.O. Papadaki, M. Slaba, K. Sevketoglu, Esra|||0000-0002-8330-2877 Valencia-Ramos, J. Yahşi, A. Tuala, C. Urbieta, A.I.D. Esteban, B.D. Santalla, M.J.D. Pérez, C.F. Villaverde, J.F. Rodríguez, C.G. Allut, J.L.G. Vicente, L.G. Vázquez, E.G. Carballa, A.G. Rial, J.G. Barcala, F.J.G. Liñares, B.G. Iglesias, P.L. Massa, B.L. Fuentes, M.L. Franco, M.L. Lago, A.L. Cruz, D.N.D.l Masid, E.N. Devesa, J.B.O. Seco, J.P. Núñez, M.P. Bernal, M.P.D.M. Freixo, H.P. Rodríguez, L.P. Pischedda, S. Romero, M.P. Reino, A.P. Hervella, G.M.P. Verdes, T.Q. Redondo Collazo, Lorenzo|||0000-0002-3521-678X Casuso, P.R. García, S.R. Vázquez, S.R. Blanco, V.R. Calle, I.R. Velasco, C.R. Núñez, N.R. Sánchez, C.R.T. Paz, E.S. Orayyou, J.M.S. Villanueva, C.S. Fernández, S.S. Sanmartín, P.S. Muñiz, M.T. Pena, R.T. Castellano, M.T. Cuadrado, L.V. García, P.V. Iglesias, M.S.V. Lasheras, S.V. Ferreiro Iglesias, Rocío|||0000-0002-0469-4332 Bastón-Rey, I. Calviño-Suárez, C. Aiuti, Alessandro|||0000-0002-5398-1717 Al-Muhsen, S. Al-Mulla, F. Amara, A. Anderson, M.S. Arias, A.A. Arkin, L.M. Feldman, H.B. Biggs, C.M. Bogunovic, Dusan|||0000-0002-9277-3232 Bolze, Alexandre|||0000-0001-7399-2766 Bondarenko, A.|||0000-0002-9737-2868 Bryceson, Y. Butte, M.J. Casari, G. Christodoulou, J. Constantinescu, S.N. Cooper, M.A. Dalgard, C.L. Desai, M. Drolet, B.A. Duval, X. Baghdadi, J.E. Eloy, P. Espinosa-Padilla, S. Fellay, Jacques|||0000-0002-8240-939X Flores, Carlos|||0000-0001-5352-069X Franco, J.L. Froidure, A. Gorochov, G. Gregersen, P.K. Grimbacher, B. Hagin, D. Halwani, R. Heath, J.R. Hsieh, E.W.Y. Husebye, Eystein Sverre|||0000-0002-7886-2976 Imai, K. Itan, Yuval Jarvis, E.D. Kaja, E. Karamitros, T. Ku, C.L. Lau, Y.L. Ling, Y. Lucas, C.L. Mansouri, D. Maródi, L. Mentré, F. Milner, J.D. Mironska, K. Mogensen, T.H. Ng, L.F.P. Notarangelo, L.D. Novelli, A. Novelli, G. O'Farrelly, C. Okamoto, K. Pape, J.W. Perez de Diego, Rebeca|||0000-0001-8426-8765 Perez-Tur, J. Perlin, D.S. Pesole, G. Planas, A.M. Quintana-Murci, L. Ramaswamy, S. Renia, L. Resnick, I. Sancho-Shimizu, V. Sediva, A. Seppänen, M.R.J. Shahrooei, M. Shcherbina, A. Slaby, O. Snow, A.L. Soler-Palacín, Pere|||0000-0002-0346-5570 Soumelis, V. Spaan, A.N. Su, H.C. Tangye, S.G. Tayoun, A.A. Temel, Ş.G. Thorball, C. Tiberghien, P. Turvey, S.E. Uddin, K.M.F. Uddin, M.J. Beek, D.v.d Bernuth, H.v Wauters, J. Zatz, Mayana|||0000-0003-3970-8025 Zawadzki, Pawel We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2. https://ddd.uab.cat/record/317410 https://dx.doi.org/urn:doi:10.1084/jem.20231353 |
| spellingShingle | Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children Bastard, Paul|||0000-0002-5926-8437 |
| title | Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children |
| title_full | Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children |
| title_fullStr | Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children |
| title_full_unstemmed | Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children |
| title_short | Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children |
| title_sort | Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children |
| url | https://ddd.uab.cat/record/317410 https://dx.doi.org/urn:doi:10.1084/jem.20231353 |