Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children...

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Detalhes bibliográficos
Autores: Bastard, Paul|||0000-0002-5926-8437; Gervais, A.; Taniguchi, M.; Saare, L.; Särekannu, K.; Voyer, T.L.; Philippot, Q.; Rosain, J.; Bizien, L.; Asano, T.; Garcia-Prat, Marina|||0000-0001-5387-1908; Parra-Martínez, Alba|||0000-0002-9564-8912; Migaud, M.; Tsumura, M.; Conti, F.; Belot, Alexandre|||0000-0003-4902-5332; Rivière, Jacques G.|||0000-0003-1055-2063; Morio, T.; Tanaka, J.; Javouhey, E.; Haerynck, F.; Duvlis, S.; Ozcelik, Tayfun|||0000-0001-5937-1082; Keles, S.; Tandjaoui-Lambiotte, Y.; Escoda, S.; Husain, M.; Pan-Hammarström, Q.; Hammarström, L.; Ahlijah, G.; Haidar, A.A.; Soudee, C.; Arseguel, V.; Abolhassani, Hassan|||0000-0002-4838-0407; Sahanic, S.; Tancevski, I.; Nukui, Y.; Hayakawa, S.; Chrousos, G.P.; Michos, A.; Tatsi, E.B.; Filippatos, F.; Rodriguez-Palmero, A.; Troya, Jesús|||0000-0001-7323-114X; Tipu, I.; Meyts, I.; Roussel, L.; Ostrowski, S.R.; Schidlowski, L.; Prando, C.; Condino-Neto, Antonio|||0000-0002-1069-3117; Cheikh, N.; Bousfiha, A.A.; Bakkouri, J.E.; Peterson, P.; Pujol, Aurora|||0000-0002-9606-0600; Lévy, R.; Quartier, P.; Vinh, D.C.; Boisson, Bertrand|||0000-0001-5240-3555; Béziat, V.; Zhang, S.Y.; Borghesi, A.; Pession, A.; Andreakos, E.; Marr, N.; Mentis, A.F.A.; H.mogensen, T.; Rodríguez-Gallego, C.; Colobrán Oriol, Roger|||0000-0002-5964-536X; Tillmann, V.; Neven, B.; Trouillet-Assant, S.; Brodin, P.; Abel, Laurent|||0000-0001-7016-6493; Jouanguy, Emmanuelle|||0000-0002-7358-9157; Zhang, Q.; Martinón Torres, Federico|||0000-0002-9023-581X; Salas, A.; Gómez-Carballa, A.; Gonzalez-Granado, L.I.; Kisand, K.; Okada, S.; Puel, A.; Cobat, Aurélie|||0000-0001-7209-6257; Casanova, Jean-Laurent|||0000-0002-7782-4169; Aguilera-Albesa, Sergio|||0000-0003-3540-1448; AlKhater, Suzan|||0000-0001-7315-6581; Alkan, G.; Castagnoli, R.; Cyrus, C.|||0000-0001-7333-6486; Bozdemir, S.E.; Emiroglu, M.; Gulhan, Belgin|||0000-0003-0839-1301; Erdeniz, E.H.; Hatipoglu, N.; Bayhan, G.I.|||0000-0002-1423-4348; Jabandziev, P.; Yuksek, S.K.; Karbuz, A.; Öz, Ş.K.T.; Marseglia, G.L.; Akcan, O.M.; Kılıç, A.O.; Parlakay, A.O.; Papadaki, M.; Slaba, K.; Sevketoglu, Esra|||0000-0002-8330-2877; Valencia-Ramos, J.; Yahşi, A.; Tuala, C.; Urbieta, A.I.D.; Esteban, B.D.; Santalla, M.J.D.; Pérez, C.F.; Villaverde, J.F.; Rodríguez, C.G.; Allut, J.L.G.; Vicente, L.G.; Vázquez, E.G.; Carballa, A.G.; Rial, J.G.; Barcala, F.J.G.; Liñares, B.G.; Iglesias, P.L.; Massa, B.L.; Fuentes, M.L.; Franco, M.L.; Lago, A.L.; Cruz, D.N.D.l; Masid, E.N.; Devesa, J.B.O.; Seco, J.P.; Núñez, M.P.; Bernal, M.P.D.M.; Freixo, H.P.; Rodríguez, L.P.; Pischedda, S.; Romero, M.P.; Reino, A.P.; Hervella, G.M.P.; Verdes, T.Q.; Redondo Collazo, Lorenzo|||0000-0002-3521-678X; Casuso, P.R.; García, S.R.; Vázquez, S.R.; Blanco, V.R.; Calle, I.R.; Velasco, C.R.; Núñez, N.R.; Sánchez, C.R.T.; Paz, E.S.; Orayyou, J.M.S.; Villanueva, C.S.; Fernández, S.S.; Sanmartín, P.S.; Muñiz, M.T.; Pena, R.T.; Castellano, M.T.; Cuadrado, L.V.; García, P.V.; Iglesias, M.S.V.; Lasheras, S.V.; Ferreiro Iglesias, Rocío|||0000-0002-0469-4332; Bastón-Rey, I.; Calviño-Suárez, C.; Aiuti, Alessandro|||0000-0002-5398-1717; Al-Muhsen, S.; Al-Mulla, F.; Amara, A.; Anderson, M.S.; Arias, A.A.; Arkin, L.M.; Feldman, H.B.; Biggs, C.M.; Bogunovic, Dusan|||0000-0002-9277-3232; Bolze, Alexandre|||0000-0001-7399-2766; Bondarenko, A.|||0000-0002-9737-2868; Bryceson, Y.; Butte, M.J.; Casari, G.; Christodoulou, J.; Constantinescu, S.N.; Cooper, M.A.; Dalgard, C.L.; Desai, M.; Drolet, B.A.; Duval, X.; Baghdadi, J.E.; Eloy, P.; Espinosa-Padilla, S.; Fellay, Jacques|||0000-0002-8240-939X; Flores, Carlos|||0000-0001-5352-069X; Franco, J.L.; Froidure, A.; Gorochov, G.; Gregersen, P.K.; Grimbacher, B.; Hagin, D.; Halwani, R.; Heath, J.R.; Hsieh, E.W.Y.; Husebye, Eystein Sverre|||0000-0002-7886-2976; Imai, K.; Itan, Yuval; Jarvis, E.D.; Kaja, E.; Karamitros, T.; Ku, C.L.; Lau, Y.L.; Ling, Y.; Lucas, C.L.; Mansouri, D.; Maródi, L.; Mentré, F.; Milner, J.D.; Mironska, K.; Mogensen, T.H.; Ng, L.F.P.; Notarangelo, L.D.; Novelli, A.; Novelli, G.; O'Farrelly, C.; Okamoto, K.; Pape, J.W.; Perez de Diego, Rebeca|||0000-0001-8426-8765; Perez-Tur, J.; Perlin, D.S.; Pesole, G.; Planas, A.M.; Quintana-Murci, L.; Ramaswamy, S.; Renia, L.; Resnick, I.; Sancho-Shimizu, V.; Sediva, A.; Seppänen, M.R.J.; Shahrooei, M.; Shcherbina, A.; Slaby, O.; Snow, A.L.; Soler-Palacín, Pere|||0000-0002-0346-5570; Soumelis, V.; Spaan, A.N.; Su, H.C.; Tangye, S.G.; Tayoun, A.A.; Temel, Ş.G.; Thorball, C.; Tiberghien, P.; Turvey, S.E.; Uddin, K.M.F.; Uddin, M.J.; Beek, D.v.d; Bernuth, H.v; Wauters, J.; Zatz, Mayana|||0000-0003-3970-8025; Zawadzki, Pawel
Tipo de documento: Artigo
Data de publicação:2024
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:Inglês
OAI Identifier:oai:ddd.uab.cat:317410
Acesso em linha:https://ddd.uab.cat/record/317410
https://dx.doi.org/urn:doi:10.1084/jem.20231353
Nível de acesso:Acesso aberto
_version_ 1878742393851740160
author Bastard, Paul|||0000-0002-5926-8437
author2 Gervais, A.
Taniguchi, M.
Saare, L.
Särekannu, K.
Voyer, T.L.
Philippot, Q.
Rosain, J.
Bizien, L.
Asano, T.
Garcia-Prat, Marina|||0000-0001-5387-1908
Parra-Martínez, Alba|||0000-0002-9564-8912
Migaud, M.
Tsumura, M.
Conti, F.
Belot, Alexandre|||0000-0003-4902-5332
Rivière, Jacques G.|||0000-0003-1055-2063
Morio, T.
Tanaka, J.
Javouhey, E.
Haerynck, F.
Duvlis, S.
Ozcelik, Tayfun|||0000-0001-5937-1082
Keles, S.
Tandjaoui-Lambiotte, Y.
Escoda, S.
Husain, M.
Pan-Hammarström, Q.
Hammarström, L.
Ahlijah, G.
Haidar, A.A.
Soudee, C.
Arseguel, V.
Abolhassani, Hassan|||0000-0002-4838-0407
Sahanic, S.
Tancevski, I.
Nukui, Y.
Hayakawa, S.
Chrousos, G.P.
Michos, A.
Tatsi, E.B.
Filippatos, F.
Rodriguez-Palmero, A.
Troya, Jesús|||0000-0001-7323-114X
Tipu, I.
Meyts, I.
Roussel, L.
Ostrowski, S.R.
Schidlowski, L.
Prando, C.
Condino-Neto, Antonio|||0000-0002-1069-3117
Cheikh, N.
Bousfiha, A.A.
Bakkouri, J.E.
Peterson, P.
Pujol, Aurora|||0000-0002-9606-0600
Lévy, R.
Quartier, P.
Vinh, D.C.
Boisson, Bertrand|||0000-0001-5240-3555
Béziat, V.
Zhang, S.Y.
Borghesi, A.
Pession, A.
Andreakos, E.
Marr, N.
Mentis, A.F.A.
H.mogensen, T.
Rodríguez-Gallego, C.
Colobrán Oriol, Roger|||0000-0002-5964-536X
Tillmann, V.
Neven, B.
Trouillet-Assant, S.
Brodin, P.
Abel, Laurent|||0000-0001-7016-6493
Jouanguy, Emmanuelle|||0000-0002-7358-9157
Zhang, Q.
Martinón Torres, Federico|||0000-0002-9023-581X
Salas, A.
Gómez-Carballa, A.
Gonzalez-Granado, L.I.
Kisand, K.
Okada, S.
Puel, A.
Cobat, Aurélie|||0000-0001-7209-6257
Casanova, Jean-Laurent|||0000-0002-7782-4169
Aguilera-Albesa, Sergio|||0000-0003-3540-1448
AlKhater, Suzan|||0000-0001-7315-6581
Alkan, G.
Castagnoli, R.
Cyrus, C.|||0000-0001-7333-6486
Bozdemir, S.E.
Emiroglu, M.
Gulhan, Belgin|||0000-0003-0839-1301
Erdeniz, E.H.
Hatipoglu, N.
Bayhan, G.I.|||0000-0002-1423-4348
Jabandziev, P.
Yuksek, S.K.
Karbuz, A.
Öz, Ş.K.T.
Marseglia, G.L.
Akcan, O.M.
Kılıç, A.O.
Parlakay, A.O.
Papadaki, M.
Slaba, K.
Sevketoglu, Esra|||0000-0002-8330-2877
Valencia-Ramos, J.
Yahşi, A.
Tuala, C.
Urbieta, A.I.D.
Esteban, B.D.
Santalla, M.J.D.
Pérez, C.F.
Villaverde, J.F.
Rodríguez, C.G.
Allut, J.L.G.
Vicente, L.G.
Vázquez, E.G.
Carballa, A.G.
Rial, J.G.
Barcala, F.J.G.
Liñares, B.G.
Iglesias, P.L.
Massa, B.L.
Fuentes, M.L.
Franco, M.L.
Lago, A.L.
Cruz, D.N.D.l
Masid, E.N.
Devesa, J.B.O.
Seco, J.P.
Núñez, M.P.
Bernal, M.P.D.M.
Freixo, H.P.
Rodríguez, L.P.
Pischedda, S.
Romero, M.P.
Reino, A.P.
Hervella, G.M.P.
Verdes, T.Q.
Redondo Collazo, Lorenzo|||0000-0002-3521-678X
Casuso, P.R.
García, S.R.
Vázquez, S.R.
Blanco, V.R.
Calle, I.R.
Velasco, C.R.
Núñez, N.R.
Sánchez, C.R.T.
Paz, E.S.
Orayyou, J.M.S.
Villanueva, C.S.
Fernández, S.S.
Sanmartín, P.S.
Muñiz, M.T.
Pena, R.T.
Castellano, M.T.
Cuadrado, L.V.
García, P.V.
Iglesias, M.S.V.
Lasheras, S.V.
Ferreiro Iglesias, Rocío|||0000-0002-0469-4332
Bastón-Rey, I.
Calviño-Suárez, C.
Aiuti, Alessandro|||0000-0002-5398-1717
Al-Muhsen, S.
Al-Mulla, F.
Amara, A.
Anderson, M.S.
Arias, A.A.
Arkin, L.M.
Feldman, H.B.
Biggs, C.M.
Bogunovic, Dusan|||0000-0002-9277-3232
Bolze, Alexandre|||0000-0001-7399-2766
Bondarenko, A.|||0000-0002-9737-2868
Bryceson, Y.
Butte, M.J.
Casari, G.
Christodoulou, J.
Constantinescu, S.N.
Cooper, M.A.
Dalgard, C.L.
Desai, M.
Drolet, B.A.
Duval, X.
Baghdadi, J.E.
Eloy, P.
Espinosa-Padilla, S.
Fellay, Jacques|||0000-0002-8240-939X
Flores, Carlos|||0000-0001-5352-069X
Franco, J.L.
Froidure, A.
Gorochov, G.
Gregersen, P.K.
Grimbacher, B.
Hagin, D.
Halwani, R.
Heath, J.R.
Hsieh, E.W.Y.
Husebye, Eystein Sverre|||0000-0002-7886-2976
Imai, K.
Itan, Yuval
Jarvis, E.D.
Kaja, E.
Karamitros, T.
Ku, C.L.
Lau, Y.L.
Ling, Y.
Lucas, C.L.
Mansouri, D.
Maródi, L.
Mentré, F.
Milner, J.D.
Mironska, K.
Mogensen, T.H.
Ng, L.F.P.
Notarangelo, L.D.
Novelli, A.
Novelli, G.
O'Farrelly, C.
Okamoto, K.
Pape, J.W.
Perez de Diego, Rebeca|||0000-0001-8426-8765
Perez-Tur, J.
Perlin, D.S.
Pesole, G.
Planas, A.M.
Quintana-Murci, L.
Ramaswamy, S.
Renia, L.
Resnick, I.
Sancho-Shimizu, V.
Sediva, A.
Seppänen, M.R.J.
Shahrooei, M.
Shcherbina, A.
Slaby, O.
Snow, A.L.
Soler-Palacín, Pere|||0000-0002-0346-5570
Soumelis, V.
Spaan, A.N.
Su, H.C.
Tangye, S.G.
Tayoun, A.A.
Temel, Ş.G.
Thorball, C.
Tiberghien, P.
Turvey, S.E.
Uddin, K.M.F.
Uddin, M.J.
Beek, D.v.d
Bernuth, H.v
Wauters, J.
Zatz, Mayana|||0000-0003-3970-8025
Zawadzki, Pawel
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author_browse Abel, Laurent|||0000-0001-7016-6493
Abolhassani, Hassan|||0000-0002-4838-0407
Aguilera-Albesa, Sergio|||0000-0003-3540-1448
Ahlijah, G.
Aiuti, Alessandro|||0000-0002-5398-1717
Akcan, O.M.
Al-Muhsen, S.
Al-Mulla, F.
AlKhater, Suzan|||0000-0001-7315-6581
Alkan, G.
Allut, J.L.G.
Amara, A.
Anderson, M.S.
Andreakos, E.
Arias, A.A.
Arkin, L.M.
Arseguel, V.
Asano, T.
Baghdadi, J.E.
Bakkouri, J.E.
Barcala, F.J.G.
Bastard, Paul|||0000-0002-5926-8437
Bastón-Rey, I.
Bayhan, G.I.|||0000-0002-1423-4348
Beek, D.v.d
Belot, Alexandre|||0000-0003-4902-5332
Bernal, M.P.D.M.
Bernuth, H.v
Biggs, C.M.
Bizien, L.
Blanco, V.R.
Bogunovic, Dusan|||0000-0002-9277-3232
Boisson, Bertrand|||0000-0001-5240-3555
Bolze, Alexandre|||0000-0001-7399-2766
Bondarenko, A.|||0000-0002-9737-2868
Borghesi, A.
Bousfiha, A.A.
Bozdemir, S.E.
Brodin, P.
Bryceson, Y.
Butte, M.J.
Béziat, V.
Calle, I.R.
Calviño-Suárez, C.
Carballa, A.G.
Casanova, Jean-Laurent|||0000-0002-7782-4169
Casari, G.
Castagnoli, R.
Castellano, M.T.
Casuso, P.R.
Cheikh, N.
Christodoulou, J.
Chrousos, G.P.
Cobat, Aurélie|||0000-0001-7209-6257
Colobrán Oriol, Roger|||0000-0002-5964-536X
Condino-Neto, Antonio|||0000-0002-1069-3117
Constantinescu, S.N.
Conti, F.
Cooper, M.A.
Cruz, D.N.D.l
Cuadrado, L.V.
Cyrus, C.|||0000-0001-7333-6486
Dalgard, C.L.
Desai, M.
Devesa, J.B.O.
Drolet, B.A.
Duval, X.
Duvlis, S.
Eloy, P.
Emiroglu, M.
Erdeniz, E.H.
Escoda, S.
Espinosa-Padilla, S.
Esteban, B.D.
Feldman, H.B.
Fellay, Jacques|||0000-0002-8240-939X
Fernández, S.S.
Ferreiro Iglesias, Rocío|||0000-0002-0469-4332
Filippatos, F.
Flores, Carlos|||0000-0001-5352-069X
Franco, J.L.
Franco, M.L.
Freixo, H.P.
Froidure, A.
Fuentes, M.L.
Garcia-Prat, Marina|||0000-0001-5387-1908
García, P.V.
García, S.R.
Gervais, A.
Gonzalez-Granado, L.I.
Gorochov, G.
Gregersen, P.K.
Grimbacher, B.
Gulhan, Belgin|||0000-0003-0839-1301
Gómez-Carballa, A.
H.mogensen, T.
Haerynck, F.
Hagin, D.
Haidar, A.A.
Halwani, R.
Hammarström, L.
Hatipoglu, N.
Hayakawa, S.
Heath, J.R.
Hervella, G.M.P.
Hsieh, E.W.Y.
Husain, M.
Husebye, Eystein Sverre|||0000-0002-7886-2976
Iglesias, M.S.V.
Iglesias, P.L.
Imai, K.
Itan, Yuval
Jabandziev, P.
Jarvis, E.D.
Javouhey, E.
Jouanguy, Emmanuelle|||0000-0002-7358-9157
Kaja, E.
Karamitros, T.
Karbuz, A.
Keles, S.
Kisand, K.
Ku, C.L.
Kılıç, A.O.
Lago, A.L.
Lasheras, S.V.
Lau, Y.L.
Ling, Y.
Liñares, B.G.
Lucas, C.L.
Lévy, R.
Mansouri, D.
Marr, N.
Marseglia, G.L.
Martinón Torres, Federico|||0000-0002-9023-581X
Maródi, L.
Masid, E.N.
Massa, B.L.
Mentis, A.F.A.
Mentré, F.
Meyts, I.
Michos, A.
Migaud, M.
Milner, J.D.
Mironska, K.
Mogensen, T.H.
Morio, T.
Muñiz, M.T.
Neven, B.
Ng, L.F.P.
Notarangelo, L.D.
Novelli, A.
Novelli, G.
Nukui, Y.
Núñez, M.P.
Núñez, N.R.
O'Farrelly, C.
Okada, S.
Okamoto, K.
Orayyou, J.M.S.
Ostrowski, S.R.
Ozcelik, Tayfun|||0000-0001-5937-1082
Pan-Hammarström, Q.
Papadaki, M.
Pape, J.W.
Parlakay, A.O.
Parra-Martínez, Alba|||0000-0002-9564-8912
Paz, E.S.
Pena, R.T.
Perez de Diego, Rebeca|||0000-0001-8426-8765
Perez-Tur, J.
Perlin, D.S.
Pesole, G.
Pession, A.
Peterson, P.
Philippot, Q.
Pischedda, S.
Planas, A.M.
Prando, C.
Puel, A.
Pujol, Aurora|||0000-0002-9606-0600
Pérez, C.F.
Quartier, P.
Quintana-Murci, L.
Ramaswamy, S.
Redondo Collazo, Lorenzo|||0000-0002-3521-678X
Reino, A.P.
Renia, L.
Resnick, I.
Rial, J.G.
Rivière, Jacques G.|||0000-0003-1055-2063
Rodriguez-Palmero, A.
Rodríguez, C.G.
Rodríguez, L.P.
Rodríguez-Gallego, C.
Romero, M.P.
Rosain, J.
Roussel, L.
Saare, L.
Sahanic, S.
Salas, A.
Sancho-Shimizu, V.
Sanmartín, P.S.
Santalla, M.J.D.
Schidlowski, L.
Seco, J.P.
Sediva, A.
Seppänen, M.R.J.
Sevketoglu, Esra|||0000-0002-8330-2877
Shahrooei, M.
Shcherbina, A.
Slaba, K.
Slaby, O.
Snow, A.L.
Soler-Palacín, Pere|||0000-0002-0346-5570
Soudee, C.
Soumelis, V.
Spaan, A.N.
Su, H.C.
Sánchez, C.R.T.
Särekannu, K.
Tanaka, J.
Tancevski, I.
Tandjaoui-Lambiotte, Y.
Tangye, S.G.
Taniguchi, M.
Tatsi, E.B.
Tayoun, A.A.
Temel, Ş.G.
Thorball, C.
Tiberghien, P.
Tillmann, V.
Tipu, I.
Trouillet-Assant, S.
Troya, Jesús|||0000-0001-7323-114X
Tsumura, M.
Tuala, C.
Turvey, S.E.
Uddin, K.M.F.
Uddin, M.J.
Urbieta, A.I.D.
Valencia-Ramos, J.
Velasco, C.R.
Verdes, T.Q.
Vicente, L.G.
Villanueva, C.S.
Villaverde, J.F.
Vinh, D.C.
Voyer, T.L.
Vázquez, E.G.
Vázquez, S.R.
Wauters, J.
Yahşi, A.
Yuksek, S.K.
Zatz, Mayana|||0000-0003-3970-8025
Zawadzki, Pawel
Zhang, Q.
Zhang, S.Y.
Öz, Ş.K.T.
author_facet Bastard, Paul|||0000-0002-5926-8437
Gervais, A.
Taniguchi, M.
Saare, L.
Särekannu, K.
Voyer, T.L.
Philippot, Q.
Rosain, J.
Bizien, L.
Asano, T.
Garcia-Prat, Marina|||0000-0001-5387-1908
Parra-Martínez, Alba|||0000-0002-9564-8912
Migaud, M.
Tsumura, M.
Conti, F.
Belot, Alexandre|||0000-0003-4902-5332
Rivière, Jacques G.|||0000-0003-1055-2063
Morio, T.
Tanaka, J.
Javouhey, E.
Haerynck, F.
Duvlis, S.
Ozcelik, Tayfun|||0000-0001-5937-1082
Keles, S.
Tandjaoui-Lambiotte, Y.
Escoda, S.
Husain, M.
Pan-Hammarström, Q.
Hammarström, L.
Ahlijah, G.
Haidar, A.A.
Soudee, C.
Arseguel, V.
Abolhassani, Hassan|||0000-0002-4838-0407
Sahanic, S.
Tancevski, I.
Nukui, Y.
Hayakawa, S.
Chrousos, G.P.
Michos, A.
Tatsi, E.B.
Filippatos, F.
Rodriguez-Palmero, A.
Troya, Jesús|||0000-0001-7323-114X
Tipu, I.
Meyts, I.
Roussel, L.
Ostrowski, S.R.
Schidlowski, L.
Prando, C.
Condino-Neto, Antonio|||0000-0002-1069-3117
Cheikh, N.
Bousfiha, A.A.
Bakkouri, J.E.
Peterson, P.
Pujol, Aurora|||0000-0002-9606-0600
Lévy, R.
Quartier, P.
Vinh, D.C.
Boisson, Bertrand|||0000-0001-5240-3555
Béziat, V.
Zhang, S.Y.
Borghesi, A.
Pession, A.
Andreakos, E.
Marr, N.
Mentis, A.F.A.
H.mogensen, T.
Rodríguez-Gallego, C.
Colobrán Oriol, Roger|||0000-0002-5964-536X
Tillmann, V.
Neven, B.
Trouillet-Assant, S.
Brodin, P.
Abel, Laurent|||0000-0001-7016-6493
Jouanguy, Emmanuelle|||0000-0002-7358-9157
Zhang, Q.
Martinón Torres, Federico|||0000-0002-9023-581X
Salas, A.
Gómez-Carballa, A.
Gonzalez-Granado, L.I.
Kisand, K.
Okada, S.
Puel, A.
Cobat, Aurélie|||0000-0001-7209-6257
Casanova, Jean-Laurent|||0000-0002-7782-4169
Aguilera-Albesa, Sergio|||0000-0003-3540-1448
AlKhater, Suzan|||0000-0001-7315-6581
Alkan, G.
Castagnoli, R.
Cyrus, C.|||0000-0001-7333-6486
Bozdemir, S.E.
Emiroglu, M.
Gulhan, Belgin|||0000-0003-0839-1301
Erdeniz, E.H.
Hatipoglu, N.
Bayhan, G.I.|||0000-0002-1423-4348
Jabandziev, P.
Yuksek, S.K.
Karbuz, A.
Öz, Ş.K.T.
Marseglia, G.L.
Akcan, O.M.
Kılıç, A.O.
Parlakay, A.O.
Papadaki, M.
Slaba, K.
Sevketoglu, Esra|||0000-0002-8330-2877
Valencia-Ramos, J.
Yahşi, A.
Tuala, C.
Urbieta, A.I.D.
Esteban, B.D.
Santalla, M.J.D.
Pérez, C.F.
Villaverde, J.F.
Rodríguez, C.G.
Allut, J.L.G.
Vicente, L.G.
Vázquez, E.G.
Carballa, A.G.
Rial, J.G.
Barcala, F.J.G.
Liñares, B.G.
Iglesias, P.L.
Massa, B.L.
Fuentes, M.L.
Franco, M.L.
Lago, A.L.
Cruz, D.N.D.l
Masid, E.N.
Devesa, J.B.O.
Seco, J.P.
Núñez, M.P.
Bernal, M.P.D.M.
Freixo, H.P.
Rodríguez, L.P.
Pischedda, S.
Romero, M.P.
Reino, A.P.
Hervella, G.M.P.
Verdes, T.Q.
Redondo Collazo, Lorenzo|||0000-0002-3521-678X
Casuso, P.R.
García, S.R.
Vázquez, S.R.
Blanco, V.R.
Calle, I.R.
Velasco, C.R.
Núñez, N.R.
Sánchez, C.R.T.
Paz, E.S.
Orayyou, J.M.S.
Villanueva, C.S.
Fernández, S.S.
Sanmartín, P.S.
Muñiz, M.T.
Pena, R.T.
Castellano, M.T.
Cuadrado, L.V.
García, P.V.
Iglesias, M.S.V.
Lasheras, S.V.
Ferreiro Iglesias, Rocío|||0000-0002-0469-4332
Bastón-Rey, I.
Calviño-Suárez, C.
Aiuti, Alessandro|||0000-0002-5398-1717
Al-Muhsen, S.
Al-Mulla, F.
Amara, A.
Anderson, M.S.
Arias, A.A.
Arkin, L.M.
Feldman, H.B.
Biggs, C.M.
Bogunovic, Dusan|||0000-0002-9277-3232
Bolze, Alexandre|||0000-0001-7399-2766
Bondarenko, A.|||0000-0002-9737-2868
Bryceson, Y.
Butte, M.J.
Casari, G.
Christodoulou, J.
Constantinescu, S.N.
Cooper, M.A.
Dalgard, C.L.
Desai, M.
Drolet, B.A.
Duval, X.
Baghdadi, J.E.
Eloy, P.
Espinosa-Padilla, S.
Fellay, Jacques|||0000-0002-8240-939X
Flores, Carlos|||0000-0001-5352-069X
Franco, J.L.
Froidure, A.
Gorochov, G.
Gregersen, P.K.
Grimbacher, B.
Hagin, D.
Halwani, R.
Heath, J.R.
Hsieh, E.W.Y.
Husebye, Eystein Sverre|||0000-0002-7886-2976
Imai, K.
Itan, Yuval
Jarvis, E.D.
Kaja, E.
Karamitros, T.
Ku, C.L.
Lau, Y.L.
Ling, Y.
Lucas, C.L.
Mansouri, D.
Maródi, L.
Mentré, F.
Milner, J.D.
Mironska, K.
Mogensen, T.H.
Ng, L.F.P.
Notarangelo, L.D.
Novelli, A.
Novelli, G.
O'Farrelly, C.
Okamoto, K.
Pape, J.W.
Perez de Diego, Rebeca|||0000-0001-8426-8765
Perez-Tur, J.
Perlin, D.S.
Pesole, G.
Planas, A.M.
Quintana-Murci, L.
Ramaswamy, S.
Renia, L.
Resnick, I.
Sancho-Shimizu, V.
Sediva, A.
Seppänen, M.R.J.
Shahrooei, M.
Shcherbina, A.
Slaby, O.
Snow, A.L.
Soler-Palacín, Pere|||0000-0002-0346-5570
Soumelis, V.
Spaan, A.N.
Su, H.C.
Tangye, S.G.
Tayoun, A.A.
Temel, Ş.G.
Thorball, C.
Tiberghien, P.
Turvey, S.E.
Uddin, K.M.F.
Uddin, M.J.
Beek, D.v.d
Bernuth, H.v
Wauters, J.
Zatz, Mayana|||0000-0003-3970-8025
Zawadzki, Pawel
author_role author
collection Dipòsit Digital de Documents de la UAB
description We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2.
eu_rights_str_mv openAccess
format article
id ES_f5220f7b584e29fb3be7861165f3a4e3
institution Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
language eng
network_acronym_str ES
network_name_str España
oai_identifier_str oai:ddd.uab.cat:317410
publishDate 2024
publishDateSort 2024
reponame_str Dipòsit Digital de Documents de la UAB
spelling Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children Bastard, Paul|||0000-0002-5926-8437 Gervais, A. Taniguchi, M. Saare, L. Särekannu, K. Voyer, T.L. Philippot, Q. Rosain, J. Bizien, L. Asano, T. Garcia-Prat, Marina|||0000-0001-5387-1908 Parra-Martínez, Alba|||0000-0002-9564-8912 Migaud, M. Tsumura, M. Conti, F. Belot, Alexandre|||0000-0003-4902-5332 Rivière, Jacques G.|||0000-0003-1055-2063 Morio, T. Tanaka, J. Javouhey, E. Haerynck, F. Duvlis, S. Ozcelik, Tayfun|||0000-0001-5937-1082 Keles, S. Tandjaoui-Lambiotte, Y. Escoda, S. Husain, M. Pan-Hammarström, Q. Hammarström, L. Ahlijah, G. Haidar, A.A. Soudee, C. Arseguel, V. Abolhassani, Hassan|||0000-0002-4838-0407 Sahanic, S. Tancevski, I. Nukui, Y. Hayakawa, S. Chrousos, G.P. Michos, A. Tatsi, E.B. Filippatos, F. Rodriguez-Palmero, A. Troya, Jesús|||0000-0001-7323-114X Tipu, I. Meyts, I. Roussel, L. Ostrowski, S.R. Schidlowski, L. Prando, C. Condino-Neto, Antonio|||0000-0002-1069-3117 Cheikh, N. Bousfiha, A.A. Bakkouri, J.E. Peterson, P. Pujol, Aurora|||0000-0002-9606-0600 Lévy, R. Quartier, P. Vinh, D.C. Boisson, Bertrand|||0000-0001-5240-3555 Béziat, V. Zhang, S.Y. Borghesi, A. Pession, A. Andreakos, E. Marr, N. Mentis, A.F.A. H.mogensen, T. Rodríguez-Gallego, C. Colobrán Oriol, Roger|||0000-0002-5964-536X Tillmann, V. Neven, B. Trouillet-Assant, S. Brodin, P. Abel, Laurent|||0000-0001-7016-6493 Jouanguy, Emmanuelle|||0000-0002-7358-9157 Zhang, Q. Martinón Torres, Federico|||0000-0002-9023-581X Salas, A. Gómez-Carballa, A. Gonzalez-Granado, L.I. Kisand, K. Okada, S. Puel, A. Cobat, Aurélie|||0000-0001-7209-6257 Casanova, Jean-Laurent|||0000-0002-7782-4169 Aguilera-Albesa, Sergio|||0000-0003-3540-1448 AlKhater, Suzan|||0000-0001-7315-6581 Alkan, G. Castagnoli, R. Cyrus, C.|||0000-0001-7333-6486 Bozdemir, S.E. Emiroglu, M. Gulhan, Belgin|||0000-0003-0839-1301 Erdeniz, E.H. Hatipoglu, N. Bayhan, G.I.|||0000-0002-1423-4348 Jabandziev, P. Yuksek, S.K. Karbuz, A. Öz, Ş.K.T. Marseglia, G.L. Akcan, O.M. Kılıç, A.O. Parlakay, A.O. Papadaki, M. Slaba, K. Sevketoglu, Esra|||0000-0002-8330-2877 Valencia-Ramos, J. Yahşi, A. Tuala, C. Urbieta, A.I.D. Esteban, B.D. Santalla, M.J.D. Pérez, C.F. Villaverde, J.F. Rodríguez, C.G. Allut, J.L.G. Vicente, L.G. Vázquez, E.G. Carballa, A.G. Rial, J.G. Barcala, F.J.G. Liñares, B.G. Iglesias, P.L. Massa, B.L. Fuentes, M.L. Franco, M.L. Lago, A.L. Cruz, D.N.D.l Masid, E.N. Devesa, J.B.O. Seco, J.P. Núñez, M.P. Bernal, M.P.D.M. Freixo, H.P. Rodríguez, L.P. Pischedda, S. Romero, M.P. Reino, A.P. Hervella, G.M.P. Verdes, T.Q. Redondo Collazo, Lorenzo|||0000-0002-3521-678X Casuso, P.R. García, S.R. Vázquez, S.R. Blanco, V.R. Calle, I.R. Velasco, C.R. Núñez, N.R. Sánchez, C.R.T. Paz, E.S. Orayyou, J.M.S. Villanueva, C.S. Fernández, S.S. Sanmartín, P.S. Muñiz, M.T. Pena, R.T. Castellano, M.T. Cuadrado, L.V. García, P.V. Iglesias, M.S.V. Lasheras, S.V. Ferreiro Iglesias, Rocío|||0000-0002-0469-4332 Bastón-Rey, I. Calviño-Suárez, C. Aiuti, Alessandro|||0000-0002-5398-1717 Al-Muhsen, S. Al-Mulla, F. Amara, A. Anderson, M.S. Arias, A.A. Arkin, L.M. Feldman, H.B. Biggs, C.M. Bogunovic, Dusan|||0000-0002-9277-3232 Bolze, Alexandre|||0000-0001-7399-2766 Bondarenko, A.|||0000-0002-9737-2868 Bryceson, Y. Butte, M.J. Casari, G. Christodoulou, J. Constantinescu, S.N. Cooper, M.A. Dalgard, C.L. Desai, M. Drolet, B.A. Duval, X. Baghdadi, J.E. Eloy, P. Espinosa-Padilla, S. Fellay, Jacques|||0000-0002-8240-939X Flores, Carlos|||0000-0001-5352-069X Franco, J.L. Froidure, A. Gorochov, G. Gregersen, P.K. Grimbacher, B. Hagin, D. Halwani, R. Heath, J.R. Hsieh, E.W.Y. Husebye, Eystein Sverre|||0000-0002-7886-2976 Imai, K. Itan, Yuval Jarvis, E.D. Kaja, E. Karamitros, T. Ku, C.L. Lau, Y.L. Ling, Y. Lucas, C.L. Mansouri, D. Maródi, L. Mentré, F. Milner, J.D. Mironska, K. Mogensen, T.H. Ng, L.F.P. Notarangelo, L.D. Novelli, A. Novelli, G. O'Farrelly, C. Okamoto, K. Pape, J.W. Perez de Diego, Rebeca|||0000-0001-8426-8765 Perez-Tur, J. Perlin, D.S. Pesole, G. Planas, A.M. Quintana-Murci, L. Ramaswamy, S. Renia, L. Resnick, I. Sancho-Shimizu, V. Sediva, A. Seppänen, M.R.J. Shahrooei, M. Shcherbina, A. Slaby, O. Snow, A.L. Soler-Palacín, Pere|||0000-0002-0346-5570 Soumelis, V. Spaan, A.N. Su, H.C. Tangye, S.G. Tayoun, A.A. Temel, Ş.G. Thorball, C. Tiberghien, P. Turvey, S.E. Uddin, K.M.F. Uddin, M.J. Beek, D.v.d Bernuth, H.v Wauters, J. Zatz, Mayana|||0000-0003-3970-8025 Zawadzki, Pawel We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2. https://ddd.uab.cat/record/317410 https://dx.doi.org/urn:doi:10.1084/jem.20231353
spellingShingle Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
Bastard, Paul|||0000-0002-5926-8437
title Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
title_full Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
title_fullStr Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
title_full_unstemmed Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
title_short Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
title_sort Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
url https://ddd.uab.cat/record/317410
https://dx.doi.org/urn:doi:10.1084/jem.20231353