One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study
The intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association b...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2022 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/55274 |
| Online Access: | http://hdl.handle.net/10230/55274 http://dx.doi.org/10.3390/antiox11081540 |
| Access Level: | Open access |
| Keyword: | Mediterranean diet PREDIMED study Bioactive compounds Cardiovascular Liquid chromatography Mass spectrometry Phytochemicals Urinary microbial phenolic metabolites |
| _version_ | 1878742105222807552 |
|---|---|
| author | Marhuenda Muñoz, María |
| author2 | Domínguez-López, Inés Laveriano-Santos, Emily P. Parilli-Moser, Isabella Razquin, Cristina Ruiz-Canela, Miguel Basterra-Gortari, F. Javier Salas-Salvadó, Jordi Fitó Colomer, Montserrat Lapetra, José Arós, Fernando Fiol, Miquel Serra-Majem, Luis Pintó Sala, Xavier Gómez-Gracia, Enrique Ros, Emilio Estruch, Ramón Lamuela Raventós, Rosa Ma. |
| author2_role | author author author author author author author author author author author author author author author author author |
| author_browse | Arós, Fernando Basterra-Gortari, F. Javier Domínguez-López, Inés Estruch, Ramón Fiol, Miquel Fitó Colomer, Montserrat Gómez-Gracia, Enrique Lamuela Raventós, Rosa Ma. Lapetra, José Laveriano-Santos, Emily P. Marhuenda Muñoz, María Parilli-Moser, Isabella Pintó Sala, Xavier Razquin, Cristina Ros, Emilio Ruiz-Canela, Miguel Salas-Salvadó, Jordi Serra-Majem, Luis |
| author_facet | Marhuenda Muñoz, María Domínguez-López, Inés Laveriano-Santos, Emily P. Parilli-Moser, Isabella Razquin, Cristina Ruiz-Canela, Miguel Basterra-Gortari, F. Javier Salas-Salvadó, Jordi Fitó Colomer, Montserrat Lapetra, José Arós, Fernando Fiol, Miquel Serra-Majem, Luis Pintó Sala, Xavier Gómez-Gracia, Enrique Ros, Emilio Estruch, Ramón Lamuela Raventós, Rosa Ma. |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | The intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association between one-year changes in urinary microbial phenolic metabolites (MPM) and the incidence of type 2 diabetes, we performed a case-control study using data and samples of the PREDIMED trial including 46 incident type 2 diabetes cases of 172 randomly selected participants. Eight urinary MPMs were quantified in urine by liquid chromatography coupled to mass spectrometry and used to assess their associations with type 2 diabetes risk by multivariable logistic regression models. Compared to participants in the lowest tertile of one-year changes in hydroxybenzoic acid glucuronide, those in the highest tertile had a significantly lowered probability of developing type 2 diabetes (OR [95% CI], 0.39 [0.23-0.64]; p < 0.001 for trend). However, when additionally adjusting for fasting plasma glucose, the statistical significance was lost. Changes in the dietary pattern can increase the concentrations of this compound, derived from many (poly)phenol-rich foods, and might be changing the gut microbial population as well, promoting the production of the metabolite. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_f039d052d2b6f1e4dfc875436d8e0e59 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:10230/55274 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI |
| publisherStr | MDPI |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study Marhuenda Muñoz, María Domínguez-López, Inés Laveriano-Santos, Emily P. Parilli-Moser, Isabella Razquin, Cristina Ruiz-Canela, Miguel Basterra-Gortari, F. Javier Salas-Salvadó, Jordi Fitó Colomer, Montserrat Lapetra, José Arós, Fernando Fiol, Miquel Serra-Majem, Luis Pintó Sala, Xavier Gómez-Gracia, Enrique Ros, Emilio Estruch, Ramón Lamuela Raventós, Rosa Ma. Mediterranean diet PREDIMED study Bioactive compounds Cardiovascular Liquid chromatography Mass spectrometry Phytochemicals Urinary microbial phenolic metabolites The intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association between one-year changes in urinary microbial phenolic metabolites (MPM) and the incidence of type 2 diabetes, we performed a case-control study using data and samples of the PREDIMED trial including 46 incident type 2 diabetes cases of 172 randomly selected participants. Eight urinary MPMs were quantified in urine by liquid chromatography coupled to mass spectrometry and used to assess their associations with type 2 diabetes risk by multivariable logistic regression models. Compared to participants in the lowest tertile of one-year changes in hydroxybenzoic acid glucuronide, those in the highest tertile had a significantly lowered probability of developing type 2 diabetes (OR [95% CI], 0.39 [0.23-0.64]; p < 0.001 for trend). However, when additionally adjusting for fasting plasma glucose, the statistical significance was lost. Changes in the dietary pattern can increase the concentrations of this compound, derived from many (poly)phenol-rich foods, and might be changing the gut microbial population as well, promoting the production of the metabolite. This research was funded by CICYT [AGL2016-75329-R] PID2020-114022RB-I00, CIBEROBN Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovación y Universidades, (AEI/FEDER 10.13039/501100011033, UE), and Generalitat de Catalunya (GC) [2017SGR196]. M.M.-M. is supported by the FPU17/00513 grant. I.D.-L. thanks the Spanish Ministry of Science Innovation and Universities for the Formación de Profesorado Universitario (FPU20/02478) contract. E.P.L.-S. is supported by the FI-SDUR (EM/3345/2020) grant from the Generalitat de Catalunya. I.P.-M. is supported by the FI-SDUR (EMC/2703/2019). MDPI http://hdl.handle.net/10230/55274 http://dx.doi.org/10.3390/antiox11081540 |
| spellingShingle | One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study Marhuenda Muñoz, María Mediterranean diet PREDIMED study Bioactive compounds Cardiovascular Liquid chromatography Mass spectrometry Phytochemicals Urinary microbial phenolic metabolites |
| status_str | publishedVersion |
| title | One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study |
| title_full | One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study |
| title_fullStr | One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study |
| title_full_unstemmed | One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study |
| title_short | One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study |
| title_sort | One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study |
| topic | Mediterranean diet PREDIMED study Bioactive compounds Cardiovascular Liquid chromatography Mass spectrometry Phytochemicals Urinary microbial phenolic metabolites |
| topic_facet | Mediterranean diet PREDIMED study Bioactive compounds Cardiovascular Liquid chromatography Mass spectrometry Phytochemicals Urinary microbial phenolic metabolites |
| url | http://hdl.handle.net/10230/55274 http://dx.doi.org/10.3390/antiox11081540 |