Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
The distribution of mutational fitness effects (DMFE) is crucial to the evolutionary fate of quasispecies. In this article we analyze the effect of the DMFE on the dynamics of a large quasispecies by means of a phenotypic version of the classic Eigen's model that incorporates beneficial, neutral, de...
| Authors: | ; ; ; ; |
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| Format: | Article |
| Publication date: | 2014 |
| Country: | España |
| Institution: | Universitat Autònoma de Barcelona |
| Repository: | Dipòsit Digital de Documents de la UAB |
| Language: | English |
| OAI Identifier: | oai:ddd.uab.cat:206005 |
| Online Access: | https://ddd.uab.cat/record/206005 https://dx.doi.org/urn:doi:10.1038/srep04625 |
| Access Level: | Open access |
| _version_ | 1878742027317805057 |
|---|---|
| author | Sardanyés, Josep|||0000-0001-7225-5158 |
| author2 | Simó, Carles Martínez Barchino, Regina|||0000-0002-1328-6744 Solé, Ricard|||0000-0001-6974-1008 Elena, Santiago F.|||0000-0001-8249-5593 |
| author2_role | author author author author |
| author_browse | Elena, Santiago F.|||0000-0001-8249-5593 Martínez Barchino, Regina|||0000-0002-1328-6744 Sardanyés, Josep|||0000-0001-7225-5158 Simó, Carles Solé, Ricard|||0000-0001-6974-1008 |
| author_facet | Sardanyés, Josep|||0000-0001-7225-5158 Simó, Carles Martínez Barchino, Regina|||0000-0002-1328-6744 Solé, Ricard|||0000-0001-6974-1008 Elena, Santiago F.|||0000-0001-8249-5593 |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | The distribution of mutational fitness effects (DMFE) is crucial to the evolutionary fate of quasispecies. In this article we analyze the effect of the DMFE on the dynamics of a large quasispecies by means of a phenotypic version of the classic Eigen's model that incorporates beneficial, neutral, deleterious, and lethal mutations. By parameterizing the model with available experimental data on the DMFE of Vesicular stomatitis virus (VSV) and Tobacco etch virus (TEV), we found that increasing mutation does not totally push the entire viral quasispecies towards deleterious or lethal regions of the phenotypic sequence space. The probability of finding regions in the parameter space of the general model that results in a quasispecies only composed by lethal phenotypes is extremely small at equilibrium and in transient times. The implications of our findings can be extended to other scenarios, such as lethal mutagenesis or genomically unstable cancer, where increased mutagenesis has been suggested as a potential therapy. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_eefd65cb33eee52ae23ebaefd8f554f2 |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:206005 |
| publishDate | 2014 |
| publishDateSort | 2014 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations Sardanyés, Josep|||0000-0001-7225-5158 Simó, Carles Martínez Barchino, Regina|||0000-0002-1328-6744 Solé, Ricard|||0000-0001-6974-1008 Elena, Santiago F.|||0000-0001-8249-5593 The distribution of mutational fitness effects (DMFE) is crucial to the evolutionary fate of quasispecies. In this article we analyze the effect of the DMFE on the dynamics of a large quasispecies by means of a phenotypic version of the classic Eigen's model that incorporates beneficial, neutral, deleterious, and lethal mutations. By parameterizing the model with available experimental data on the DMFE of Vesicular stomatitis virus (VSV) and Tobacco etch virus (TEV), we found that increasing mutation does not totally push the entire viral quasispecies towards deleterious or lethal regions of the phenotypic sequence space. The probability of finding regions in the parameter space of the general model that results in a quasispecies only composed by lethal phenotypes is extremely small at equilibrium and in transient times. The implications of our findings can be extended to other scenarios, such as lethal mutagenesis or genomically unstable cancer, where increased mutagenesis has been suggested as a potential therapy. https://ddd.uab.cat/record/206005 https://dx.doi.org/urn:doi:10.1038/srep04625 |
| spellingShingle | Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations Sardanyés, Josep|||0000-0001-7225-5158 |
| title | Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations |
| title_full | Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations |
| title_fullStr | Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations |
| title_full_unstemmed | Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations |
| title_short | Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations |
| title_sort | Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations |
| url | https://ddd.uab.cat/record/206005 https://dx.doi.org/urn:doi:10.1038/srep04625 |