Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC
This study evaluated the impact of donor age on clinical outcomes in 274 patients with acute myeloid leukemia (AML) haplo-HCT using PTCY-based prophylaxis. Median patient age was 53 years, with 42.6% classified as high-risk AML. The median donor age of 38 years; 31% were under 30. An optimal donor a...
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| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| Repositorio: | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| OAI Identifier: | oai:iibsantpau.fundanetsuite.com:p20789 |
| Acceso en línea: | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20789 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | donor age allo-HCT haplo-HCT PTCY AML |
| _version_ | 1878741992843771904 |
|---|---|
| author | Munárriz, D |
| author2 | Pérez-Lopez, E Rodríguez, CM Luque, M Esquirol, A Calvo, CM Aparicio, C Peña-Muñoz, F Fernando, IH Ormtegi, IO Marín, AJS Fernández-Luis, S Domínguez-García, JJ Fernández, SV Lopez-Lorenzo, JL Fleitas, CA González-Rodriguez, AP García, L Torrado, T Filaferro, S Balsalobre, P Cascon, MJP Rovira, M Salas, MQ |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Aparicio, C Balsalobre, P Calvo, CM Cascon, MJP Domínguez-García, JJ Esquirol, A Fernando, IH Fernández, SV Fernández-Luis, S Filaferro, S Fleitas, CA García, L González-Rodriguez, AP Lopez-Lorenzo, JL Luque, M Marín, AJS Munárriz, D Ormtegi, IO Peña-Muñoz, F Pérez-Lopez, E Rodríguez, CM Rovira, M Salas, MQ Torrado, T |
| author_facet | Munárriz, D Pérez-Lopez, E Rodríguez, CM Luque, M Esquirol, A Calvo, CM Aparicio, C Peña-Muñoz, F Fernando, IH Ormtegi, IO Marín, AJS Fernández-Luis, S Domínguez-García, JJ Fernández, SV Lopez-Lorenzo, JL Fleitas, CA González-Rodriguez, AP García, L Torrado, T Filaferro, S Balsalobre, P Cascon, MJP Rovira, M Salas, MQ |
| author_role | author |
| collection | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| description | This study evaluated the impact of donor age on clinical outcomes in 274 patients with acute myeloid leukemia (AML) haplo-HCT using PTCY-based prophylaxis. Median patient age was 53 years, with 42.6% classified as high-risk AML. The median donor age of 38 years; 31% were under 30. An optimal donor age cut-off of 30 years was identified through ROC analysis. Patients receiving grafts from younger donors (<30 years) showed lower rates of aGVHD grade II-IV (3.0% vs. 19.9%, p < 0.001) and grade III-IV (1.5% vs. 10.2%, p = 0.034), with no differences in cGVHD or relapse rates. Overall survival (OS) was higher in the younger donor group (2-year: 80.6% vs. 64.3%, p = 0.011), along by lower non-relapse mortality (NRM) (2-year: 11.1% vs. 23.2%, p = 0.031). Multivariate analysis confirmed donor age >= 30 years as an independent adverse factor for OS (HR: 1.88, p = 0.019) and NRM (HR: 2.06, p = 0.049), along with older recipient age, higher HCT-CI score, and high-risk AML. These findings suggest that younger donor age contributes to improved survival, primarily through reduced NRM and aGVHD, supporting prioritization of younger donors when multiple haploidentical options are available to optimize transplant outcomes. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_ee75d5cd0e71a62028b080b9ec187f3e |
| institution | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| instname_str | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:iibsantpau.fundanetsuite.com:p20789 |
| publishDate | 2025 |
| publishDateSort | 2025 |
| publisher | FRONTIERS MEDIA SA |
| publisherStr | FRONTIERS MEDIA SA |
| reponame_str | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| spelling | Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC Munárriz, D Pérez-Lopez, E Rodríguez, CM Luque, M Esquirol, A Calvo, CM Aparicio, C Peña-Muñoz, F Fernando, IH Ormtegi, IO Marín, AJS Fernández-Luis, S Domínguez-García, JJ Fernández, SV Lopez-Lorenzo, JL Fleitas, CA González-Rodriguez, AP García, L Torrado, T Filaferro, S Balsalobre, P Cascon, MJP Rovira, M Salas, MQ donor age allo-HCT haplo-HCT PTCY AML This study evaluated the impact of donor age on clinical outcomes in 274 patients with acute myeloid leukemia (AML) haplo-HCT using PTCY-based prophylaxis. Median patient age was 53 years, with 42.6% classified as high-risk AML. The median donor age of 38 years; 31% were under 30. An optimal donor age cut-off of 30 years was identified through ROC analysis. Patients receiving grafts from younger donors (<30 years) showed lower rates of aGVHD grade II-IV (3.0% vs. 19.9%, p < 0.001) and grade III-IV (1.5% vs. 10.2%, p = 0.034), with no differences in cGVHD or relapse rates. Overall survival (OS) was higher in the younger donor group (2-year: 80.6% vs. 64.3%, p = 0.011), along by lower non-relapse mortality (NRM) (2-year: 11.1% vs. 23.2%, p = 0.031). Multivariate analysis confirmed donor age >= 30 years as an independent adverse factor for OS (HR: 1.88, p = 0.019) and NRM (HR: 2.06, p = 0.049), along with older recipient age, higher HCT-CI score, and high-risk AML. These findings suggest that younger donor age contributes to improved survival, primarily through reduced NRM and aGVHD, supporting prioritization of younger donors when multiple haploidentical options are available to optimize transplant outcomes. FRONTIERS MEDIA SA https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20789 |
| spellingShingle | Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC Munárriz, D donor age allo-HCT haplo-HCT PTCY AML |
| status_str | publishedVersion |
| title | Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC |
| title_full | Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC |
| title_fullStr | Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC |
| title_full_unstemmed | Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC |
| title_short | Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC |
| title_sort | Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC |
| topic | donor age allo-HCT haplo-HCT PTCY AML |
| topic_facet | donor age allo-HCT haplo-HCT PTCY AML |
| url | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20789 |