Exploring the genetics of lithium response in bipolar disorders.
Background: Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has been shown to have beneficial effects on disease-associated conditions, including...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2024 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/225088 |
| Online Access: | https://hdl.handle.net/2445/225088 |
| Access Level: | Open access |
| Keyword: | Trastorn bipolar Comorbiditat Genètica Manic-depressive illness Comorbidity Genetics |
| _version_ | 1878741927102251008 |
|---|---|
| author | Herrera-Rivero, Marisol |
| author2 | Adli, Mazda Akiyama, Kazufumi Akula, Nirmala Amare, Azmeraw T. Ardau, Raffaella Arias, Bárbara Aubry, Jean-Michel Backlund, Lena Bellivier, Frank Benabarre, Antonio Bengesser, Susanne Bhattacharjee, Abesh Kumar Biernacka, Joanna M. Birner, Armin Cearns, Micah Cervantes, Pablo Chen, Hsi-Chung Chillotti, Caterina Cichon, Sven Clark, Scott R. Colom, Francesc Cruceanu, Cristiana Czerski, Piotr M. Dalkner, Nina Degenhardt, Franziska Zompo, Maria del DePaulo, J. Raymond Etain, Bruno Falkai, Peter Ferensztajn-Rochowiak, Ewa Forstner, Andreas J. Frank, Josef Frisén, Louise Frye, Mark A. Fullerton, Janice M. Gallo, Carla Gard, Sébastien Garnham, Julie S. Goes, Fernando S. Grigoroiu-Serbanescu, Maria Gro, Paul Hashimoto, Ryota Hasler, Roland Hauser, Joanna Heilbronner, Urs Herms, Stefan Hoffmann, Per Hou, Liping Hsu, Yi-Hsiang Jamain, Stephane Jimenez, Esther Kahn, Jean-Pierre Kassem, Layla Kato, Tadafumi Kelsoe, John Kittel-Schneider, Sarah Kuo, Po-Hsiu Kusumi, Ichiro König, Barbara Laje, Gonzalo Landén, Mikael Lavebratt, Catharina Leboyer, Marion Leckband, Susan G. Maj, Mario Manchia, Mirko Marie-Claire, Cynthia Martinsson, Lina McCarthy, Michael J. McElroy, Susan L. Millischer, Vincent Mitjans Niubó, Marina Mondimore, Francis M. Monteleone, Palmiero Nievergelt, Caroline M. Novák, Tomas Nöthen, Markus M. O'Donovan, Claire Ozaki, Norio Papiol, Sergi Pfennig, Andrea Pisanu, Claudia Potash, James B. Reif, Andreas Reininghaus, Eva Richard-Lepouriel, Hélène Roberts, Gloria Rouleau, Guy A. Rybakowski, Janusz K. Schalling, Martin Schofield, Peter R. Schubert, Klaus Oliver Schulte, Eva C. Schweizer, Barbara W. Severino, Giovanni Shekhtman, Tatyana Shilling, Paul D. Shimoda, Katzutaka Simhandl, Christian Slaney, Claire M. Squassina, Alessio Stamm, Thomas Stopkova, Pavla Streit, Fabian Tekola-Ayele, Fasil Thalamuthu, Anbupalam Tortorella, Alfonso Turecki, Gustavo Veeh, Julia Vieta i Pascual, Eduard, 1963- Viswanath, Biju Witt, Stephanie H. Zandi, Peter P. Alda, Martin Bauer, Michael McMahon, Francis J. Mitchell, Philip B. Rietschel, Marcella Schulze, Thomas G. Baune, Bernhard T. |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Adli, Mazda Akiyama, Kazufumi Akula, Nirmala Alda, Martin Amare, Azmeraw T. Ardau, Raffaella Arias, Bárbara Aubry, Jean-Michel Backlund, Lena Bauer, Michael Baune, Bernhard T. Bellivier, Frank Benabarre, Antonio Bengesser, Susanne Bhattacharjee, Abesh Kumar Biernacka, Joanna M. Birner, Armin Cearns, Micah Cervantes, Pablo Chen, Hsi-Chung Chillotti, Caterina Cichon, Sven Clark, Scott R. Colom, Francesc Cruceanu, Cristiana Czerski, Piotr M. Dalkner, Nina DePaulo, J. Raymond Degenhardt, Franziska Etain, Bruno Falkai, Peter Ferensztajn-Rochowiak, Ewa Forstner, Andreas J. Frank, Josef Frisén, Louise Frye, Mark A. Fullerton, Janice M. Gallo, Carla Gard, Sébastien Garnham, Julie S. Goes, Fernando S. Grigoroiu-Serbanescu, Maria Gro, Paul Hashimoto, Ryota Hasler, Roland Hauser, Joanna Heilbronner, Urs Herms, Stefan Herrera-Rivero, Marisol Hoffmann, Per Hou, Liping Hsu, Yi-Hsiang Jamain, Stephane Jimenez, Esther Kahn, Jean-Pierre Kassem, Layla Kato, Tadafumi Kelsoe, John Kittel-Schneider, Sarah Kuo, Po-Hsiu Kusumi, Ichiro König, Barbara Laje, Gonzalo Landén, Mikael Lavebratt, Catharina Leboyer, Marion Leckband, Susan G. Maj, Mario Manchia, Mirko Marie-Claire, Cynthia Martinsson, Lina McCarthy, Michael J. McElroy, Susan L. McMahon, Francis J. Millischer, Vincent Mitchell, Philip B. Mitjans Niubó, Marina Mondimore, Francis M. Monteleone, Palmiero Nievergelt, Caroline M. Novák, Tomas Nöthen, Markus M. O'Donovan, Claire Ozaki, Norio Papiol, Sergi Pfennig, Andrea Pisanu, Claudia Potash, James B. Reif, Andreas Reininghaus, Eva Richard-Lepouriel, Hélène Rietschel, Marcella Roberts, Gloria Rouleau, Guy A. Rybakowski, Janusz K. Schalling, Martin Schofield, Peter R. Schubert, Klaus Oliver Schulte, Eva C. Schulze, Thomas G. Schweizer, Barbara W. Severino, Giovanni Shekhtman, Tatyana Shilling, Paul D. Shimoda, Katzutaka Simhandl, Christian Slaney, Claire M. Squassina, Alessio Stamm, Thomas Stopkova, Pavla Streit, Fabian Tekola-Ayele, Fasil Thalamuthu, Anbupalam Tortorella, Alfonso Turecki, Gustavo Veeh, Julia Vieta i Pascual, Eduard, 1963- Viswanath, Biju Witt, Stephanie H. Zandi, Peter P. Zompo, Maria del |
| author_facet | Herrera-Rivero, Marisol Adli, Mazda Akiyama, Kazufumi Akula, Nirmala Amare, Azmeraw T. Ardau, Raffaella Arias, Bárbara Aubry, Jean-Michel Backlund, Lena Bellivier, Frank Benabarre, Antonio Bengesser, Susanne Bhattacharjee, Abesh Kumar Biernacka, Joanna M. Birner, Armin Cearns, Micah Cervantes, Pablo Chen, Hsi-Chung Chillotti, Caterina Cichon, Sven Clark, Scott R. Colom, Francesc Cruceanu, Cristiana Czerski, Piotr M. Dalkner, Nina Degenhardt, Franziska Zompo, Maria del DePaulo, J. Raymond Etain, Bruno Falkai, Peter Ferensztajn-Rochowiak, Ewa Forstner, Andreas J. Frank, Josef Frisén, Louise Frye, Mark A. Fullerton, Janice M. Gallo, Carla Gard, Sébastien Garnham, Julie S. Goes, Fernando S. Grigoroiu-Serbanescu, Maria Gro, Paul Hashimoto, Ryota Hasler, Roland Hauser, Joanna Heilbronner, Urs Herms, Stefan Hoffmann, Per Hou, Liping Hsu, Yi-Hsiang Jamain, Stephane Jimenez, Esther Kahn, Jean-Pierre Kassem, Layla Kato, Tadafumi Kelsoe, John Kittel-Schneider, Sarah Kuo, Po-Hsiu Kusumi, Ichiro König, Barbara Laje, Gonzalo Landén, Mikael Lavebratt, Catharina Leboyer, Marion Leckband, Susan G. Maj, Mario Manchia, Mirko Marie-Claire, Cynthia Martinsson, Lina McCarthy, Michael J. McElroy, Susan L. Millischer, Vincent Mitjans Niubó, Marina Mondimore, Francis M. Monteleone, Palmiero Nievergelt, Caroline M. Novák, Tomas Nöthen, Markus M. O'Donovan, Claire Ozaki, Norio Papiol, Sergi Pfennig, Andrea Pisanu, Claudia Potash, James B. Reif, Andreas Reininghaus, Eva Richard-Lepouriel, Hélène Roberts, Gloria Rouleau, Guy A. Rybakowski, Janusz K. Schalling, Martin Schofield, Peter R. Schubert, Klaus Oliver Schulte, Eva C. Schweizer, Barbara W. Severino, Giovanni Shekhtman, Tatyana Shilling, Paul D. Shimoda, Katzutaka Simhandl, Christian Slaney, Claire M. Squassina, Alessio Stamm, Thomas Stopkova, Pavla Streit, Fabian Tekola-Ayele, Fasil Thalamuthu, Anbupalam Tortorella, Alfonso Turecki, Gustavo Veeh, Julia Vieta i Pascual, Eduard, 1963- Viswanath, Biju Witt, Stephanie H. Zandi, Peter P. Alda, Martin Bauer, Michael McMahon, Francis J. Mitchell, Philip B. Rietschel, Marcella Schulze, Thomas G. Baune, Bernhard T. |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Background: Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has been shown to have beneficial effects on disease-associated conditions, including sleep and cardiovascular disorders. However, the individual responses to Li treatment vary within and between diagnostic subtypes of BP (e.g. BP-I and BP-II) according to the clinical presentation. Moreover, long-term Li treatment has been linked to adverse side-effects that are a cause of concern and non-adherence, including the risk of developing chronic medical conditions such as thyroid and renal disease. In recent years, studies by the Consortium on Lithium Genetics (ConLiGen) have uncovered a number of genetic factors that contribute to the variability in Li treatment response in patients with BP. Here, we leveraged the ConLiGen cohort (N = 2064) to investigate the genetic basis of Li effects in BP. For this, we studied how Li response and linked genes associate with the psychiatric symptoms and polygenic load for medical comorbidities, placing particular emphasis on identifying differences between BP-I and BP-II. Results: We found that clinical response to Li treatment, measured with the Alda scale, was associated with a diminished burden of mania, depression, substance and alcohol abuse, psychosis and suicidal ideation in patients with BP-I and, in patients with BP-II, of depression only. Our genetic analyses showed that a stronger clinical response to Li was modestly related to lower polygenic load for diabetes and hypertension in BP-I but not BP-II. Moreover, our results suggested that a number of genes that have been previously linked to Li response variability in BP differentially relate to the psychiatric symptomatology, particularly to the numbers of manic and depressive episodes, and to the polygenic load for comorbid conditions, including diabetes, hypertension and hypothyroidism. Conclusions: Taken together, our findings suggest that the effects of Li on symptomatology and comorbidity in BP are partially modulated by common genetic factors, with differential effects between BP-I and BP-II. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_ed84807304cf2bbe96dbb76309146b8f |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/225088 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| publisher | Springer Open |
| publisherStr | Springer Open |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Exploring the genetics of lithium response in bipolar disorders. Herrera-Rivero, Marisol Adli, Mazda Akiyama, Kazufumi Akula, Nirmala Amare, Azmeraw T. Ardau, Raffaella Arias, Bárbara Aubry, Jean-Michel Backlund, Lena Bellivier, Frank Benabarre, Antonio Bengesser, Susanne Bhattacharjee, Abesh Kumar Biernacka, Joanna M. Birner, Armin Cearns, Micah Cervantes, Pablo Chen, Hsi-Chung Chillotti, Caterina Cichon, Sven Clark, Scott R. Colom, Francesc Cruceanu, Cristiana Czerski, Piotr M. Dalkner, Nina Degenhardt, Franziska Zompo, Maria del DePaulo, J. Raymond Etain, Bruno Falkai, Peter Ferensztajn-Rochowiak, Ewa Forstner, Andreas J. Frank, Josef Frisén, Louise Frye, Mark A. Fullerton, Janice M. Gallo, Carla Gard, Sébastien Garnham, Julie S. Goes, Fernando S. Grigoroiu-Serbanescu, Maria Gro, Paul Hashimoto, Ryota Hasler, Roland Hauser, Joanna Heilbronner, Urs Herms, Stefan Hoffmann, Per Hou, Liping Hsu, Yi-Hsiang Jamain, Stephane Jimenez, Esther Kahn, Jean-Pierre Kassem, Layla Kato, Tadafumi Kelsoe, John Kittel-Schneider, Sarah Kuo, Po-Hsiu Kusumi, Ichiro König, Barbara Laje, Gonzalo Landén, Mikael Lavebratt, Catharina Leboyer, Marion Leckband, Susan G. Maj, Mario Manchia, Mirko Marie-Claire, Cynthia Martinsson, Lina McCarthy, Michael J. McElroy, Susan L. Millischer, Vincent Mitjans Niubó, Marina Mondimore, Francis M. Monteleone, Palmiero Nievergelt, Caroline M. Novák, Tomas Nöthen, Markus M. O'Donovan, Claire Ozaki, Norio Papiol, Sergi Pfennig, Andrea Pisanu, Claudia Potash, James B. Reif, Andreas Reininghaus, Eva Richard-Lepouriel, Hélène Roberts, Gloria Rouleau, Guy A. Rybakowski, Janusz K. Schalling, Martin Schofield, Peter R. Schubert, Klaus Oliver Schulte, Eva C. Schweizer, Barbara W. Severino, Giovanni Shekhtman, Tatyana Shilling, Paul D. Shimoda, Katzutaka Simhandl, Christian Slaney, Claire M. Squassina, Alessio Stamm, Thomas Stopkova, Pavla Streit, Fabian Tekola-Ayele, Fasil Thalamuthu, Anbupalam Tortorella, Alfonso Turecki, Gustavo Veeh, Julia Vieta i Pascual, Eduard, 1963- Viswanath, Biju Witt, Stephanie H. Zandi, Peter P. Alda, Martin Bauer, Michael McMahon, Francis J. Mitchell, Philip B. Rietschel, Marcella Schulze, Thomas G. Baune, Bernhard T. Trastorn bipolar Comorbiditat Genètica Manic-depressive illness Comorbidity Genetics Background: Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has been shown to have beneficial effects on disease-associated conditions, including sleep and cardiovascular disorders. However, the individual responses to Li treatment vary within and between diagnostic subtypes of BP (e.g. BP-I and BP-II) according to the clinical presentation. Moreover, long-term Li treatment has been linked to adverse side-effects that are a cause of concern and non-adherence, including the risk of developing chronic medical conditions such as thyroid and renal disease. In recent years, studies by the Consortium on Lithium Genetics (ConLiGen) have uncovered a number of genetic factors that contribute to the variability in Li treatment response in patients with BP. Here, we leveraged the ConLiGen cohort (N = 2064) to investigate the genetic basis of Li effects in BP. For this, we studied how Li response and linked genes associate with the psychiatric symptoms and polygenic load for medical comorbidities, placing particular emphasis on identifying differences between BP-I and BP-II. Results: We found that clinical response to Li treatment, measured with the Alda scale, was associated with a diminished burden of mania, depression, substance and alcohol abuse, psychosis and suicidal ideation in patients with BP-I and, in patients with BP-II, of depression only. Our genetic analyses showed that a stronger clinical response to Li was modestly related to lower polygenic load for diabetes and hypertension in BP-I but not BP-II. Moreover, our results suggested that a number of genes that have been previously linked to Li response variability in BP differentially relate to the psychiatric symptomatology, particularly to the numbers of manic and depressive episodes, and to the polygenic load for comorbid conditions, including diabetes, hypertension and hypothyroidism. Conclusions: Taken together, our findings suggest that the effects of Li on symptomatology and comorbidity in BP are partially modulated by common genetic factors, with differential effects between BP-I and BP-II. Springer Open https://hdl.handle.net/2445/225088 |
| spellingShingle | Exploring the genetics of lithium response in bipolar disorders. Herrera-Rivero, Marisol Trastorn bipolar Comorbiditat Genètica Manic-depressive illness Comorbidity Genetics |
| status_str | publishedVersion |
| title | Exploring the genetics of lithium response in bipolar disorders. |
| title_full | Exploring the genetics of lithium response in bipolar disorders. |
| title_fullStr | Exploring the genetics of lithium response in bipolar disorders. |
| title_full_unstemmed | Exploring the genetics of lithium response in bipolar disorders. |
| title_short | Exploring the genetics of lithium response in bipolar disorders. |
| title_sort | Exploring the genetics of lithium response in bipolar disorders. |
| topic | Trastorn bipolar Comorbiditat Genètica Manic-depressive illness Comorbidity Genetics |
| topic_facet | Trastorn bipolar Comorbiditat Genètica Manic-depressive illness Comorbidity Genetics |
| url | https://hdl.handle.net/2445/225088 |