Ingenol mebutate for the treatment of actinic keratosis: effectiveness and safety in 246 patients treated in real-life clinical practice.
Introduction: The aim of the study was to evaluate the results on effectiveness and safety of topical treatment for actinic keratosis (AK) with ingenol mebutate gel (IMG) in real-life conditions and to perform an analysis of the factors that may influence the treatment outcomes. Materials and method...
| Authors: | ; |
|---|---|
| Format: | Article |
| Publication date: | 2018 |
| Country: | España |
| Institution: | Universidad de Navarra |
| Repository: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Language: | English |
| OAI Identifier: | oai:dadun.unav.edu:10171/68828 |
| Online Access: | https://hdl.handle.net/10171/68828 |
| Access Level: | Open access |
| Keyword: | Actinic keratosis Ingenol mebutate gel Skin cancer Topical therapy |
| _version_ | 1878741817727385600 |
|---|---|
| author | Ortega, R.M. (Rosa María)|||/items/9281d0ed-ca87-4b39-a773-c54f48ec9ff5 |
| author2 | Salido-Vallejo, R. (Rafael)|||/items/358e939a-9001-4a19-a55d-f8dc95c53c34 |
| author2_role | author |
| author_browse | Ortega, R.M. (Rosa María)|||/items/9281d0ed-ca87-4b39-a773-c54f48ec9ff5 Salido-Vallejo, R. (Rafael)|||/items/358e939a-9001-4a19-a55d-f8dc95c53c34 |
| author_facet | Ortega, R.M. (Rosa María)|||/items/9281d0ed-ca87-4b39-a773-c54f48ec9ff5 Salido-Vallejo, R. (Rafael)|||/items/358e939a-9001-4a19-a55d-f8dc95c53c34 |
| author_role | author |
| collection | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| description | Introduction: The aim of the study was to evaluate the results on effectiveness and safety of topical treatment for actinic keratosis (AK) with ingenol mebutate gel (IMG) in real-life conditions and to perform an analysis of the factors that may influence the treatment outcomes. Materials and methods: Retrospective study of patients with non-hyperkeratotic AK lesions prescribed with IMG in Spain according to clinical practice. Dermatologists reported the characteristics of patients and AK at baseline, and the findings observed up to 60 d after treatment. Results and conclusions: A total of 260 treatments in 246 patients with a mean (SD) age 70.6 (10.4) years were reviewed. The number of clinically visible AK in the treated area decreased from 6.16 (3.02) to 1.22 (2.02) (p < .001) lesions with an average reduction of 84%. Univariate analysis showed higher reduction rates when IMG was applied in the face/scalp (p = .026), in women (p = .041), and in patients under 70 years of age (p = .033). According to multivariate analysis, advanced age was associated with worse clearance rates (p = .038). However, besides statistical significance, we can conclude that gender (female) and age (under 70 years-old) show a tendency to have better efficacy outcomes but without clinical relevance. Topical IMG was generally well tolerated and had positive cosmetic results after 60 d. Age influences on IMG effectiveness for AK and LSRs were correlated with higher effectiveness ratios. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_ebdde2f8a40bbf1a563eed2a0e2245fb |
| institution | Universidad de Navarra |
| instname_str | Universidad de Navarra |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:dadun.unav.edu:10171/68828 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher | Taylor & Francis |
| publisherStr | Taylor & Francis |
| reponame_str | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| spelling | Ingenol mebutate for the treatment of actinic keratosis: effectiveness and safety in 246 patients treated in real-life clinical practice. Ortega, R.M. (Rosa María)|||/items/9281d0ed-ca87-4b39-a773-c54f48ec9ff5 Salido-Vallejo, R. (Rafael)|||/items/358e939a-9001-4a19-a55d-f8dc95c53c34 Actinic keratosis Ingenol mebutate gel Skin cancer Topical therapy Introduction: The aim of the study was to evaluate the results on effectiveness and safety of topical treatment for actinic keratosis (AK) with ingenol mebutate gel (IMG) in real-life conditions and to perform an analysis of the factors that may influence the treatment outcomes. Materials and methods: Retrospective study of patients with non-hyperkeratotic AK lesions prescribed with IMG in Spain according to clinical practice. Dermatologists reported the characteristics of patients and AK at baseline, and the findings observed up to 60 d after treatment. Results and conclusions: A total of 260 treatments in 246 patients with a mean (SD) age 70.6 (10.4) years were reviewed. The number of clinically visible AK in the treated area decreased from 6.16 (3.02) to 1.22 (2.02) (p < .001) lesions with an average reduction of 84%. Univariate analysis showed higher reduction rates when IMG was applied in the face/scalp (p = .026), in women (p = .041), and in patients under 70 years of age (p = .033). According to multivariate analysis, advanced age was associated with worse clearance rates (p = .038). However, besides statistical significance, we can conclude that gender (female) and age (under 70 years-old) show a tendency to have better efficacy outcomes but without clinical relevance. Topical IMG was generally well tolerated and had positive cosmetic results after 60 d. Age influences on IMG effectiveness for AK and LSRs were correlated with higher effectiveness ratios. Taylor & Francis https://hdl.handle.net/10171/68828 |
| spellingShingle | Ingenol mebutate for the treatment of actinic keratosis: effectiveness and safety in 246 patients treated in real-life clinical practice. Ortega, R.M. (Rosa María)|||/items/9281d0ed-ca87-4b39-a773-c54f48ec9ff5 Actinic keratosis Ingenol mebutate gel Skin cancer Topical therapy |
| title | Ingenol mebutate for the treatment of actinic keratosis: effectiveness and safety in 246 patients treated in real-life clinical practice. |
| title_full | Ingenol mebutate for the treatment of actinic keratosis: effectiveness and safety in 246 patients treated in real-life clinical practice. |
| title_fullStr | Ingenol mebutate for the treatment of actinic keratosis: effectiveness and safety in 246 patients treated in real-life clinical practice. |
| title_full_unstemmed | Ingenol mebutate for the treatment of actinic keratosis: effectiveness and safety in 246 patients treated in real-life clinical practice. |
| title_short | Ingenol mebutate for the treatment of actinic keratosis: effectiveness and safety in 246 patients treated in real-life clinical practice. |
| title_sort | Ingenol mebutate for the treatment of actinic keratosis: effectiveness and safety in 246 patients treated in real-life clinical practice. |
| topic | Actinic keratosis Ingenol mebutate gel Skin cancer Topical therapy |
| topic_facet | Actinic keratosis Ingenol mebutate gel Skin cancer Topical therapy |
| url | https://hdl.handle.net/10171/68828 |