Dropout rate in randomised controlled trials of balance and gait rehabilitation in multiple sclerosis: is it expected to be different for virtual reality-based interventions? A systematic review with meta-analysis and meta-regression
To assess and meta-analyse the pooled dropout rate from the randomised control trilas that use virtual reality for balance or gait rehabilitation in people with multiple sclerosis. A systematic review of randomised control trials with meta-analysis and meta-regressions was performed. A search was co...
| Authors: | ; ; ; ; ; |
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| Format: | Article |
| Status: | Accepted version |
| Publication date: | 2023 |
| Country: | España |
| Institution: | Universidad de Sevilla (US) |
| Repository: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/158538 |
| Online Access: | https://hdl.handle.net/11441/158538 https://doi.org/10.1007/s10055-022-00733-4 |
| Access Level: | Open access |
| Keyword: | Dropout rate Multiple sclerosis Adherence Virtual reality Attrition |
| _version_ | 1878741805702316032 |
|---|---|
| author | Casuso-Holgado, María Jesús |
| author2 | Garcia Muñoz, Cristina Martín-Valero, Rocío Lucena-Antón, David Moral-Muñoz, José A. Cortés Vega, María Dolores |
| author2_role | author author author author author |
| author_browse | Casuso-Holgado, María Jesús Cortés Vega, María Dolores Garcia Muñoz, Cristina Lucena-Antón, David Martín-Valero, Rocío Moral-Muñoz, José A. |
| author_facet | Casuso-Holgado, María Jesús Garcia Muñoz, Cristina Martín-Valero, Rocío Lucena-Antón, David Moral-Muñoz, José A. Cortés Vega, María Dolores |
| author_role | author |
| collection | idUS. Depósito de Investigación de la Universidad de Sevilla |
| description | To assess and meta-analyse the pooled dropout rate from the randomised control trilas that use virtual reality for balance or gait rehabilitation in people with multiple sclerosis. A systematic review of randomised control trials with meta-analysis and meta-regressions was performed. A search was conducted in PubMed, Scopus, Web of Science, the Physiotherapy Evidence Database, the Cochrane Database, CINHAL, LILACS, ScienceDirect, and ProQuest. It was last updated in July 2022. After the selection of studies, a quality appraisal was carried out using the PEDro Scale and the Revised Cochrane risk-of-bias tool for randomised trials. A descriptive analysis of main characteristics and dropout information was performed. An overall proportion meta-analysis calculated the pooled dropout rate. Odds ratio meta-analysis compared the dropout likelihood between interventions. The meta-regression evaluated the infuence of moderators related to dropout. Sixteen studies with 656 participants were included. The overall pooled dropout rate was 6.6% and 5.7% for virtual reality and 9.7% in control groups. The odds ratio (0.89, p=0.46) indicated no diferences in the probability of dropouts between the interventions. The number, duration, frequency, and weeks of sessions, intervention, sex, multiple sclerosis phenotype, Expanded Disability Status Scale score, and PEDro score were not moderators (p>0.05). Adverse events were not reported and could not be analysed as moderators. Dropouts across the virtual reality and control comparators were similar without signifcant diferences. Nonetheless, there is a slight trend that could favour virtual reality. Standardisation in reporting dropouts and adverse events is recommended for future trials. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_eba4ae907ef032ed23dd01be7db04cc7 |
| institution | Universidad de Sevilla (US) |
| instname_str | Universidad de Sevilla (US) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:idus.us.es:11441/158538 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher | SPRINGER LONDON LTD |
| publisherStr | SPRINGER LONDON LTD |
| reponame_str | idUS. Depósito de Investigación de la Universidad de Sevilla |
| spelling | Dropout rate in randomised controlled trials of balance and gait rehabilitation in multiple sclerosis: is it expected to be different for virtual reality-based interventions? A systematic review with meta-analysis and meta-regression Casuso-Holgado, María Jesús Garcia Muñoz, Cristina Martín-Valero, Rocío Lucena-Antón, David Moral-Muñoz, José A. Cortés Vega, María Dolores Dropout rate Multiple sclerosis Adherence Virtual reality Attrition To assess and meta-analyse the pooled dropout rate from the randomised control trilas that use virtual reality for balance or gait rehabilitation in people with multiple sclerosis. A systematic review of randomised control trials with meta-analysis and meta-regressions was performed. A search was conducted in PubMed, Scopus, Web of Science, the Physiotherapy Evidence Database, the Cochrane Database, CINHAL, LILACS, ScienceDirect, and ProQuest. It was last updated in July 2022. After the selection of studies, a quality appraisal was carried out using the PEDro Scale and the Revised Cochrane risk-of-bias tool for randomised trials. A descriptive analysis of main characteristics and dropout information was performed. An overall proportion meta-analysis calculated the pooled dropout rate. Odds ratio meta-analysis compared the dropout likelihood between interventions. The meta-regression evaluated the infuence of moderators related to dropout. Sixteen studies with 656 participants were included. The overall pooled dropout rate was 6.6% and 5.7% for virtual reality and 9.7% in control groups. The odds ratio (0.89, p=0.46) indicated no diferences in the probability of dropouts between the interventions. The number, duration, frequency, and weeks of sessions, intervention, sex, multiple sclerosis phenotype, Expanded Disability Status Scale score, and PEDro score were not moderators (p>0.05). Adverse events were not reported and could not be analysed as moderators. Dropouts across the virtual reality and control comparators were similar without signifcant diferences. Nonetheless, there is a slight trend that could favour virtual reality. Standardisation in reporting dropouts and adverse events is recommended for future trials. SPRINGER LONDON LTD https://hdl.handle.net/11441/158538 https://doi.org/10.1007/s10055-022-00733-4 |
| spellingShingle | Dropout rate in randomised controlled trials of balance and gait rehabilitation in multiple sclerosis: is it expected to be different for virtual reality-based interventions? A systematic review with meta-analysis and meta-regression Casuso-Holgado, María Jesús Dropout rate Multiple sclerosis Adherence Virtual reality Attrition |
| status_str | acceptedVersion |
| title | Dropout rate in randomised controlled trials of balance and gait rehabilitation in multiple sclerosis: is it expected to be different for virtual reality-based interventions? A systematic review with meta-analysis and meta-regression |
| title_full | Dropout rate in randomised controlled trials of balance and gait rehabilitation in multiple sclerosis: is it expected to be different for virtual reality-based interventions? A systematic review with meta-analysis and meta-regression |
| title_fullStr | Dropout rate in randomised controlled trials of balance and gait rehabilitation in multiple sclerosis: is it expected to be different for virtual reality-based interventions? A systematic review with meta-analysis and meta-regression |
| title_full_unstemmed | Dropout rate in randomised controlled trials of balance and gait rehabilitation in multiple sclerosis: is it expected to be different for virtual reality-based interventions? A systematic review with meta-analysis and meta-regression |
| title_short | Dropout rate in randomised controlled trials of balance and gait rehabilitation in multiple sclerosis: is it expected to be different for virtual reality-based interventions? A systematic review with meta-analysis and meta-regression |
| title_sort | Dropout rate in randomised controlled trials of balance and gait rehabilitation in multiple sclerosis: is it expected to be different for virtual reality-based interventions? A systematic review with meta-analysis and meta-regression |
| topic | Dropout rate Multiple sclerosis Adherence Virtual reality Attrition |
| topic_facet | Dropout rate Multiple sclerosis Adherence Virtual reality Attrition |
| url | https://hdl.handle.net/11441/158538 https://doi.org/10.1007/s10055-022-00733-4 |