p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model
Tauopathies are a group of neurodegenerative diseases characterized by the accumulation of hyperphosphorylated tau protein in the brain. Many of these pathologies also present an inflammatory component determined by the activation of microglia, the resident immune cells of the brain. p38 MAPK is one...
| Authors: | ; ; ; ; ; ; |
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| Format: | Article |
| Publication date: | 2022 |
| Country: | España |
| Institution: | Universidad Autónoma de Madrid |
| Repository: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Language: | English |
| OAI Identifier: | oai:repositorio.uam.es:10486/719204 |
| Online Access: | http://hdl.handle.net/10486/719204 https://dx.doi.org/10.1038/s41598-022-05980-8 |
| Access Level: | Open access |
| Keyword: | Tauopathies p38 mitogen-activated protein kinases Microglia Alzheimer's disease Hippocampus Biología y Biomedicina / Biología |
| _version_ | 1878741770003546112 |
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| author | Perea, Juan R. |
| author2 | García, Esther Vallés-Saiz, Laura Cuadros, Raquel Hernández Pérez, Félix Bolós, Marta Ávila, Jesús |
| author2_role | author author author author author author |
| author_browse | Bolós, Marta Cuadros, Raquel García, Esther Hernández Pérez, Félix Perea, Juan R. Vallés-Saiz, Laura Ávila, Jesús |
| author_facet | Perea, Juan R. García, Esther Vallés-Saiz, Laura Cuadros, Raquel Hernández Pérez, Félix Bolós, Marta Ávila, Jesús |
| author_role | author |
| collection | Biblos-e Archivo. Repositorio Institucional de la UAM |
| description | Tauopathies are a group of neurodegenerative diseases characterized by the accumulation of hyperphosphorylated tau protein in the brain. Many of these pathologies also present an inflammatory component determined by the activation of microglia, the resident immune cells of the brain. p38 MAPK is one of the molecular pathways involved in neuroinflammation. Although this kinase is expressed mainly in glia, its activation in certain neurodegenerative diseases such as Alzheimer's Disease has been associated with its ability to phosphorylate tau in neurons. Using the P301S Tauopathy mouse model, here we show that p38 activation increases during aging and that this occurs mainly in microglia of the hippocampus rather than in neurons. Furthermore, we have observed that these mice present an activated microglial variant called rod microglia. Interestingly, p38 activation in this subpopulation of microglia is decreased. On the basis of our findings, we propose that rod microglia might have a neuroprotective phenotype in the context of tau pathology |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_eb112e13e495cfb73dc23b754752cffb |
| institution | Universidad Autónoma de Madrid |
| instname_str | Universidad Autónoma de Madrid |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositorio.uam.es:10486/719204 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher | Nature Research |
| publisherStr | Nature Research |
| reponame_str | Biblos-e Archivo. Repositorio Institucional de la UAM |
| spelling | p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model Perea, Juan R. García, Esther Vallés-Saiz, Laura Cuadros, Raquel Hernández Pérez, Félix Bolós, Marta Ávila, Jesús Tauopathies p38 mitogen-activated protein kinases Microglia Alzheimer's disease Hippocampus Biología y Biomedicina / Biología Tauopathies are a group of neurodegenerative diseases characterized by the accumulation of hyperphosphorylated tau protein in the brain. Many of these pathologies also present an inflammatory component determined by the activation of microglia, the resident immune cells of the brain. p38 MAPK is one of the molecular pathways involved in neuroinflammation. Although this kinase is expressed mainly in glia, its activation in certain neurodegenerative diseases such as Alzheimer's Disease has been associated with its ability to phosphorylate tau in neurons. Using the P301S Tauopathy mouse model, here we show that p38 activation increases during aging and that this occurs mainly in microglia of the hippocampus rather than in neurons. Furthermore, we have observed that these mice present an activated microglial variant called rod microglia. Interestingly, p38 activation in this subpopulation of microglia is decreased. On the basis of our findings, we propose that rod microglia might have a neuroprotective phenotype in the context of tau pathology This research was funded by the Spanish Ministry of Science and Innovation (BES-2015-074405, PGC2018-096177-B-I00), the Center for Networked Biomedical Research on Neurodegenerative Diseases, and the Comunidad de Madrid (S2017/BMD). Institutional grants from the Fundación Ramón Areces and Banco de Santander are also acknowledged. The authors would like to thank the confocal microscopy facility at CBMSO for technical assistance, and Dr. Peter Davies for the donation of the phospho-Tau antibody (PHF-1) Nature Research http://hdl.handle.net/10486/719204 https://dx.doi.org/10.1038/s41598-022-05980-8 |
| spellingShingle | p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model Perea, Juan R. Tauopathies p38 mitogen-activated protein kinases Microglia Alzheimer's disease Hippocampus Biología y Biomedicina / Biología |
| title | p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model |
| title_full | p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model |
| title_fullStr | p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model |
| title_full_unstemmed | p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model |
| title_short | p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model |
| title_sort | p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model |
| topic | Tauopathies p38 mitogen-activated protein kinases Microglia Alzheimer's disease Hippocampus Biología y Biomedicina / Biología |
| topic_facet | Tauopathies p38 mitogen-activated protein kinases Microglia Alzheimer's disease Hippocampus Biología y Biomedicina / Biología |
| url | http://hdl.handle.net/10486/719204 https://dx.doi.org/10.1038/s41598-022-05980-8 |