Semaphorin 3C exacerbates liver fibrosis.

Chronic liver disease is a growing epidemic, leading to fibrosis and cirrhosis. TGF-ß is the pivotal profibrogenic cytokine that activates HSC, yet other molecules can modulate TGF-ß signaling during liver fibrosis. Expression of the axon guidance molecules semaphorins (SEMAs), which signal through...

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Authors: De Angelis Rigotti F; Wiedmann L; Hubert MO; Vacca M; Hasan SS; Moll I; Carvajal S; Jiménez W; Starostecka M; Billeter AT; Müller-Stich B; Wolff G; Ekim-Üstünel B; Herzig S; Fandos-Ramo C; Krätzner R; Reich M; Keitel-Anselmino V; Heikenwälder M; Mogler C; Fischer A; Rodriguez-Vita J
Format: Article
Status:Published version
Publication date:2023
Country:España
Institution:Centro de Investigación Principe Felipe (CIPF)
Repository:r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
OAI Identifier:oai:cipf.fundanetsuite.com:p4088
Online Access:https://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4088
Access Level:Open access
Summary:Chronic liver disease is a growing epidemic, leading to fibrosis and cirrhosis. TGF-ß is the pivotal profibrogenic cytokine that activates HSC, yet other molecules can modulate TGF-ß signaling during liver fibrosis. Expression of the axon guidance molecules semaphorins (SEMAs), which signal through plexins and neuropilins (NRPs), have been associated with liver fibrosis in HBV-induced chronic hepatitis. This study aims at determining their function in the regulation of HSCs.

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