Semaphorin 3C exacerbates liver fibrosis.
Chronic liver disease is a growing epidemic, leading to fibrosis and cirrhosis. TGF-ß is the pivotal profibrogenic cytokine that activates HSC, yet other molecules can modulate TGF-ß signaling during liver fibrosis. Expression of the axon guidance molecules semaphorins (SEMAs), which signal through...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2023 |
| Country: | España |
| Institution: | Centro de Investigación Principe Felipe (CIPF) |
| Repository: | r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) |
| OAI Identifier: | oai:cipf.fundanetsuite.com:p4088 |
| Online Access: | https://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4088 |
| Access Level: | Open access |
| _version_ | 1878741769900785664 |
|---|---|
| author | De Angelis Rigotti F |
| author2 | Wiedmann L Hubert MO Vacca M Hasan SS Moll I Carvajal S Jiménez W Starostecka M Billeter AT Müller-Stich B Wolff G Ekim-Üstünel B Herzig S Fandos-Ramo C Krätzner R Reich M Keitel-Anselmino V Heikenwälder M Mogler C Fischer A Rodriguez-Vita J |
| author2_role | author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Billeter AT Carvajal S De Angelis Rigotti F Ekim-Üstünel B Fandos-Ramo C Fischer A Hasan SS Heikenwälder M Herzig S Hubert MO Jiménez W Keitel-Anselmino V Krätzner R Mogler C Moll I Müller-Stich B Reich M Rodriguez-Vita J Starostecka M Vacca M Wiedmann L Wolff G |
| author_facet | De Angelis Rigotti F Wiedmann L Hubert MO Vacca M Hasan SS Moll I Carvajal S Jiménez W Starostecka M Billeter AT Müller-Stich B Wolff G Ekim-Üstünel B Herzig S Fandos-Ramo C Krätzner R Reich M Keitel-Anselmino V Heikenwälder M Mogler C Fischer A Rodriguez-Vita J |
| author_role | author |
| collection | r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) |
| description | Chronic liver disease is a growing epidemic, leading to fibrosis and cirrhosis. TGF-ß is the pivotal profibrogenic cytokine that activates HSC, yet other molecules can modulate TGF-ß signaling during liver fibrosis. Expression of the axon guidance molecules semaphorins (SEMAs), which signal through plexins and neuropilins (NRPs), have been associated with liver fibrosis in HBV-induced chronic hepatitis. This study aims at determining their function in the regulation of HSCs. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_eb0f33ca8d1be77ec615ca3ebf31d2fa |
| institution | Centro de Investigación Principe Felipe (CIPF) |
| instname_str | Centro de Investigación Principe Felipe (CIPF) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:cipf.fundanetsuite.com:p4088 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher | LIPPINCOTT WILLIAMS & WILKINS |
| publisherStr | LIPPINCOTT WILLIAMS & WILKINS |
| reponame_str | r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) |
| spelling | Semaphorin 3C exacerbates liver fibrosis. De Angelis Rigotti F Wiedmann L Hubert MO Vacca M Hasan SS Moll I Carvajal S Jiménez W Starostecka M Billeter AT Müller-Stich B Wolff G Ekim-Üstünel B Herzig S Fandos-Ramo C Krätzner R Reich M Keitel-Anselmino V Heikenwälder M Mogler C Fischer A Rodriguez-Vita J Chronic liver disease is a growing epidemic, leading to fibrosis and cirrhosis. TGF-ß is the pivotal profibrogenic cytokine that activates HSC, yet other molecules can modulate TGF-ß signaling during liver fibrosis. Expression of the axon guidance molecules semaphorins (SEMAs), which signal through plexins and neuropilins (NRPs), have been associated with liver fibrosis in HBV-induced chronic hepatitis. This study aims at determining their function in the regulation of HSCs. LIPPINCOTT WILLIAMS & WILKINS https://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4088 |
| spellingShingle | Semaphorin 3C exacerbates liver fibrosis. De Angelis Rigotti F |
| status_str | publishedVersion |
| title | Semaphorin 3C exacerbates liver fibrosis. |
| title_full | Semaphorin 3C exacerbates liver fibrosis. |
| title_fullStr | Semaphorin 3C exacerbates liver fibrosis. |
| title_full_unstemmed | Semaphorin 3C exacerbates liver fibrosis. |
| title_short | Semaphorin 3C exacerbates liver fibrosis. |
| title_sort | Semaphorin 3C exacerbates liver fibrosis. |
| url | https://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4088 |