Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story
MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a ste...
| Authors: | ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2016 |
| Country: | España |
| Institution: | Universitat Pompeu Fabra |
| Repository: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/28321 |
| Online Access: | http://hdl.handle.net/10230/28321 http://dx.doi.org/10.1111/all.12880 |
| Access Level: | Open access |
| Keyword: | Asthma IgE Multimorbidity Polysensitization Rhinitis |
| _version_ | 1878741472874856448 |
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| author | Bousquet, Jean |
| author2 | Antó i Boqué, Josep Maria Sunyer Deu, Jordi Melén, Erik Benet, Marta Basagaña Flores, Xavier Torrent Quetglas, Maties Xu, Cheng-Jian |
| author2_role | author author author author author author author |
| author_browse | Antó i Boqué, Josep Maria Basagaña Flores, Xavier Benet, Marta Bousquet, Jean Melén, Erik Sunyer Deu, Jordi Torrent Quetglas, Maties Xu, Cheng-Jian |
| author_facet | Bousquet, Jean Antó i Boqué, Josep Maria Sunyer Deu, Jordi Melén, Erik Benet, Marta Basagaña Flores, Xavier Torrent Quetglas, Maties Xu, Cheng-Jian |
| author_role | author |
| collection | Repositorio Digital de la UPF |
| description | MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_e5ca4e6dfd2f59933e787351642cb2fb |
| institution | Universitat Pompeu Fabra |
| instname_str | Universitat Pompeu Fabra |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositori.upf.edu:10230/28321 |
| publishDate | 2016 |
| publishDateSort | 2016 |
| publisher | Wiley |
| publisherStr | Wiley |
| reponame_str | Repositorio Digital de la UPF |
| spelling | Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story Bousquet, Jean Antó i Boqué, Josep Maria Sunyer Deu, Jordi Melén, Erik Benet, Marta Basagaña Flores, Xavier Torrent Quetglas, Maties Xu, Cheng-Jian Asthma IgE Multimorbidity Polysensitization Rhinitis MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda. Mechanisms of the Development of ALL ergy; EU FP 7‐CP ‐IP ; Project No: 261357; 2010–2015 Wiley http://hdl.handle.net/10230/28321 http://dx.doi.org/10.1111/all.12880 |
| spellingShingle | Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story Bousquet, Jean Asthma IgE Multimorbidity Polysensitization Rhinitis |
| status_str | publishedVersion |
| title | Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story |
| title_full | Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story |
| title_fullStr | Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story |
| title_full_unstemmed | Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story |
| title_short | Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story |
| title_sort | Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story |
| topic | Asthma IgE Multimorbidity Polysensitization Rhinitis |
| topic_facet | Asthma IgE Multimorbidity Polysensitization Rhinitis |
| url | http://hdl.handle.net/10230/28321 http://dx.doi.org/10.1111/all.12880 |