Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development
Adipose tissue releases bioactive mediators called adipokines. This review focuses on the effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of Apoptosis (TWEAK) and nephroblastoma overexpressed (NOV/CCN3) on obesity and diabetes. Omentin is produced by the stromal-...
| Authors: | ; ; ; ; ; ; ; |
|---|---|
| Format: | Book chapter |
| Publication date: | 2017 |
| Country: | España |
| Institution: | Universidad del País Vasco |
| Repository: | Addi. Archivo Digital para la Docencia y la Investigación |
| OAI Identifier: | oai:addi.ehu.eus:10810/30653 |
| Online Access: | http://hdl.handle.net/10810/30653 |
| Access Level: | Open access |
| Keyword: | adipokines omentin vaspin cardiotrophin-1 TWEAK and NOV CCN3 |
| _version_ | 1878741424968564737 |
|---|---|
| author | Escoté, Xabier |
| author2 | Gómez Zorita, Saioa López Yoldi, Miguel Milton Laskibar, Iñaki Fernández Quintela, Alfredo Martínez, José Alfredo Moreno Aliaga, María J. Portillo Baquedano, María Puy |
| author2_role | author author author author author author author |
| author_browse | Escoté, Xabier Fernández Quintela, Alfredo Gómez Zorita, Saioa López Yoldi, Miguel Martínez, José Alfredo Milton Laskibar, Iñaki Moreno Aliaga, María J. Portillo Baquedano, María Puy |
| author_facet | Escoté, Xabier Gómez Zorita, Saioa López Yoldi, Miguel Milton Laskibar, Iñaki Fernández Quintela, Alfredo Martínez, José Alfredo Moreno Aliaga, María J. Portillo Baquedano, María Puy |
| author_role | author |
| collection | Addi. Archivo Digital para la Docencia y la Investigación |
| description | Adipose tissue releases bioactive mediators called adipokines. This review focuses on the effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of Apoptosis (TWEAK) and nephroblastoma overexpressed (NOV/CCN3) on obesity and diabetes. Omentin is produced by the stromal-vascular fraction of visceral adipose tissue. Obesity reduces omentin serum concentrations and adipose tissue secretion in adults and adolescents. This adipokine regulates insulin sensitivity, but its clinical relevance has to be confirmed. Vaspin is produced by visceral and subcutaneous adipose tissues. Vaspin levels are higher in obese subjects, as well as in subjects showing insulin resistance or type 2 diabetes. Cardiotrophin-1 is an adipokine with a similar structure as cytokines from interleukin-6 family. There is some controversy regarding the regulation of cardiotrophin-1 levels in obese -subjects, but gene expression levels of cardiotrophin-1 are down-regulated in white adipose tissue from diet-induced obese mice. It also shows anti-obesity and hypoglycemic properties. TWEAK is a potential regulator of the low-grade chronic inflammation characteristic of obesity. TWEAK levels seem not to be directly related to adiposity, and metabolic factors play a critical role in its regulation. Finally, a strong correlation has been found between plasma NOV/CCN3 concentration and fat mass. This adipokine improves insulin actions. |
| eu_rights_str_mv | openAccess |
| format | bookPart |
| id | ES_e4ea601f4ebd3fb70283fbc3a3b0dc42 |
| institution | Universidad del País Vasco |
| instname_str | Universidad del País Vasco |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:addi.ehu.eus:10810/30653 |
| publishDate | 2017 |
| publishDateSort | 2017 |
| publisher | MDPI |
| publisherStr | MDPI |
| reponame_str | Addi. Archivo Digital para la Docencia y la Investigación |
| spelling | Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development Escoté, Xabier Gómez Zorita, Saioa López Yoldi, Miguel Milton Laskibar, Iñaki Fernández Quintela, Alfredo Martínez, José Alfredo Moreno Aliaga, María J. Portillo Baquedano, María Puy adipokines omentin vaspin cardiotrophin-1 TWEAK and NOV CCN3 Adipose tissue releases bioactive mediators called adipokines. This review focuses on the effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of Apoptosis (TWEAK) and nephroblastoma overexpressed (NOV/CCN3) on obesity and diabetes. Omentin is produced by the stromal-vascular fraction of visceral adipose tissue. Obesity reduces omentin serum concentrations and adipose tissue secretion in adults and adolescents. This adipokine regulates insulin sensitivity, but its clinical relevance has to be confirmed. Vaspin is produced by visceral and subcutaneous adipose tissues. Vaspin levels are higher in obese subjects, as well as in subjects showing insulin resistance or type 2 diabetes. Cardiotrophin-1 is an adipokine with a similar structure as cytokines from interleukin-6 family. There is some controversy regarding the regulation of cardiotrophin-1 levels in obese -subjects, but gene expression levels of cardiotrophin-1 are down-regulated in white adipose tissue from diet-induced obese mice. It also shows anti-obesity and hypoglycemic properties. TWEAK is a potential regulator of the low-grade chronic inflammation characteristic of obesity. TWEAK levels seem not to be directly related to adiposity, and metabolic factors play a critical role in its regulation. Finally, a strong correlation has been found between plasma NOV/CCN3 concentration and fat mass. This adipokine improves insulin actions. This study was supported by grants from the Ministerio de Economia y Competitividad (AGL-2015-65719-FEDER-UE and BFU2015-65937-R), Government of the Basque Country (IT-572-13), University of the Basque Country (UPV/EHU) (ELDUNANOTEK UFI11/32), Linea Especial about Nutrition, Obesity and Health from the University of Navarra LE/97, Department of Health, Government of Navarra (67-2015) and Instituto de Salud Carlos III (CIBERobn). I. Milton-Laskibar is a PhD fellowship from the Basque Government and S. Gomez-Zorita is a post-doc fellowship from CIBERobn. MDPI http://hdl.handle.net/10810/30653 |
| spellingShingle | Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development Escoté, Xabier adipokines omentin vaspin cardiotrophin-1 TWEAK and NOV CCN3 |
| title | Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development |
| title_full | Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development |
| title_fullStr | Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development |
| title_full_unstemmed | Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development |
| title_short | Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development |
| title_sort | Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development |
| topic | adipokines omentin vaspin cardiotrophin-1 TWEAK and NOV CCN3 |
| topic_facet | adipokines omentin vaspin cardiotrophin-1 TWEAK and NOV CCN3 |
| url | http://hdl.handle.net/10810/30653 |