Association of 24 h-movement behaviors with cerebral and hippocampal amyloid beta levels and executive function in cognitively normal older adults: a compositional data analysis from the AGUEDA trial
Objectives: This study investigated the associations between movement behaviors (physical activity, sedentary behavior, and sleep duration), global and hippocampal amyloid beta levels, and executive function in cognitively normal older adults. Design: Cross-sectional analysis using data from the Act...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2025 |
| Country: | España |
| Institution: | Universitat Pompeu Fabra |
| Repository: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:dnet:rdupf_______::ba6901e99279dd4fcc39e6bd782d2bfa |
| Online Access: | https://hdl.handle.net/10230/73373 http://dx.doi.org/10.1016/j.jsams.2025.04.011 |
| Access Level: | Open access |
| Keyword: | APOEε4 Accelerometers Alzheimer&apos s disease Cognitive function Dementia Positron emission tomography |
| _version_ | 1878741395892600832 |
|---|---|
| author | Sclafani, Alessandro |
| author2 | Migueles, Jairo H. Olvera-Rojas, Marcos Solis-Urra, Patricio Fernandez-Gamez, Beatriz Coca-Pulido, Andrea Bellón, Darío Fernández-Ortega, Javier Sanchez-Martinez, Javier Sánchez-Aranda, Lucía Toval, Ángel Martín-Fuentes, Isabel Bakker, Esmée A. Gispert, Juan Domingo Triviño-Ibañez, Eva M. Liu-Ambrose, Teresa Erickson, Kirk I. Gomez-Rio, Manuel Ortega, Francisco B. Esteban-Cornejo, Irene |
| author2_role | author author author author author author author author author author author author author author author author author author author |
| author_browse | Bakker, Esmée A. Bellón, Darío Coca-Pulido, Andrea Erickson, Kirk I. Esteban-Cornejo, Irene Fernandez-Gamez, Beatriz Fernández-Ortega, Javier Gispert, Juan Domingo Gomez-Rio, Manuel Liu-Ambrose, Teresa Martín-Fuentes, Isabel Migueles, Jairo H. Olvera-Rojas, Marcos Ortega, Francisco B. Sanchez-Martinez, Javier Sclafani, Alessandro Solis-Urra, Patricio Sánchez-Aranda, Lucía Toval, Ángel Triviño-Ibañez, Eva M. |
| author_facet | Sclafani, Alessandro Migueles, Jairo H. Olvera-Rojas, Marcos Solis-Urra, Patricio Fernandez-Gamez, Beatriz Coca-Pulido, Andrea Bellón, Darío Fernández-Ortega, Javier Sanchez-Martinez, Javier Sánchez-Aranda, Lucía Toval, Ángel Martín-Fuentes, Isabel Bakker, Esmée A. Gispert, Juan Domingo Triviño-Ibañez, Eva M. Liu-Ambrose, Teresa Erickson, Kirk I. Gomez-Rio, Manuel Ortega, Francisco B. Esteban-Cornejo, Irene |
| author_role | author |
| collection | Repositorio Digital de la UPF |
| description | Objectives: This study investigated the associations between movement behaviors (physical activity, sedentary behavior, and sleep duration), global and hippocampal amyloid beta levels, and executive function in cognitively normal older adults. Design: Cross-sectional analysis using data from the Active Gains in brain Using Exercise During Aging study, including 86 participants (mean age 71.51 years, 57% female). Methods: Movement behaviors were assessed using a wrist-worn accelerometer over a 9-day. Amyloid beta levels were quantified via positron emission tomography, and executive function was assessed using validated cognitive tests (e.g., Trail Making Test, Digit Symbol Substitution Test, Spatial Working Memory test, and Dimensional Change Card Sort test). Compositional data analysis and multiple linear regression models were used to examine associations, adjusting for age, sex, education, and APOEε4 genotype status. Results: No significant associations emerged between any movement behaviors and total cerebral amyloid beta levels or executive function (all p > 0.05). However, higher moderate-to-vigorous physical activity was significantly associated with lower hippocampal amyloid levels in males (β = -0.039, p = 0.010), but not in females (β = 0.004, p = 0.741) (Moderate-to-vigorous physical activity × sex interaction p = 0.017). Conclusions: Movement behaviors were not associated with global amyloid levels or executive function. However, higher moderate-to-vigorous physical activity may be protective against hippocampal amyloid levels in older males. Further research is needed to confirm these findings and explore potential sex differences. These results underscore the importance of moderate-to-vigorous physical activity in brain health and suggest avenues for future research on the role of movement behaviors in amyloid burden. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_e474e9ea3de233cfc8dc0d9fba2d2b88 |
| institution | Universitat Pompeu Fabra |
| instname_str | Universitat Pompeu Fabra |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:dnet:rdupf_______::ba6901e99279dd4fcc39e6bd782d2bfa |
| publishDate | 2025 |
| publishDateSort | 2025 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| reponame_str | Repositorio Digital de la UPF |
| spelling | Association of 24 h-movement behaviors with cerebral and hippocampal amyloid beta levels and executive function in cognitively normal older adults: a compositional data analysis from the AGUEDA trial Sclafani, Alessandro Migueles, Jairo H. Olvera-Rojas, Marcos Solis-Urra, Patricio Fernandez-Gamez, Beatriz Coca-Pulido, Andrea Bellón, Darío Fernández-Ortega, Javier Sanchez-Martinez, Javier Sánchez-Aranda, Lucía Toval, Ángel Martín-Fuentes, Isabel Bakker, Esmée A. Gispert, Juan Domingo Triviño-Ibañez, Eva M. Liu-Ambrose, Teresa Erickson, Kirk I. Gomez-Rio, Manuel Ortega, Francisco B. Esteban-Cornejo, Irene APOEε4 Accelerometers Alzheimer&apos s disease Cognitive function Dementia Positron emission tomography Objectives: This study investigated the associations between movement behaviors (physical activity, sedentary behavior, and sleep duration), global and hippocampal amyloid beta levels, and executive function in cognitively normal older adults. Design: Cross-sectional analysis using data from the Active Gains in brain Using Exercise During Aging study, including 86 participants (mean age 71.51 years, 57% female). Methods: Movement behaviors were assessed using a wrist-worn accelerometer over a 9-day. Amyloid beta levels were quantified via positron emission tomography, and executive function was assessed using validated cognitive tests (e.g., Trail Making Test, Digit Symbol Substitution Test, Spatial Working Memory test, and Dimensional Change Card Sort test). Compositional data analysis and multiple linear regression models were used to examine associations, adjusting for age, sex, education, and APOEε4 genotype status. Results: No significant associations emerged between any movement behaviors and total cerebral amyloid beta levels or executive function (all p > 0.05). However, higher moderate-to-vigorous physical activity was significantly associated with lower hippocampal amyloid levels in males (β = -0.039, p = 0.010), but not in females (β = 0.004, p = 0.741) (Moderate-to-vigorous physical activity × sex interaction p = 0.017). Conclusions: Movement behaviors were not associated with global amyloid levels or executive function. However, higher moderate-to-vigorous physical activity may be protective against hippocampal amyloid levels in older males. Further research is needed to confirm these findings and explore potential sex differences. These results underscore the importance of moderate-to-vigorous physical activity in brain health and suggest avenues for future research on the role of movement behaviors in amyloid burden. This work was supported by grants RTI2018-095284-J-I00, PID2022-137399OB-I00 and CNS2024-154835, funded by MCIN/AEI/10.13039/501100011033/ and “ERDF A way of making Europe”, and grant RYC2019-027287-I funded by MCIN/AEI/10.13039/501100011033/ and “ESF Investing in your future”. PS-U was supported by a “Margarita Salas” grant from the Spanish Ministry Universities, Plan Andaluz de Investigación (PAIDI) (Convocatoria 2020, Ref: P20_00124) 2021–2022, Ministerio de Economía y Competitividad–Proyectos I + D + I RETOS (Convocatoria 2020, Ref: PID2020-120249RB-I00), EXERNET Research Network on Exercise and Health (DEP2005-00046/ACTI; 09/UPB/19; 45/UPB/20; 27/UPB/21), and University of Granada “Proyectos de investigación precompetitivos para jóvenes investigadores” (Convocatoria 2021, Ref: PPJIA2021-39). JHM is supported by the Spanish Ministry of Science, Innovation and Universities under Beatriz Galindo's 2022 fellowship program (ref: BG22/00075). MOR, LSA, JFO and ACP are supported by the Spanish Ministry of Science, Innovation and Universities (FPU 22/02476, FPU 21/06192, FPU 22/03052 and FPU 21/02594, respectively). BFG is supported by MCIN/AEI/10.13039/501100011033 and FSE + (PID2022-137399OB-I00). JSM is supported by the National Agency for Research and Development (ANID)/Scholarship Program/DOCTORADO BECAS CHILE/2022 (Grant No. 72220164). JDG has received research support from F. Hoffmann–La Roche, Roche Diagnostics, GE HealthCare and Life Molecular Imaging, speaker or consultant fees from Biogen, Roche Diagnostics, Philips Nederlands, Esteve and Life Molecular Imaging and served in the Molecular Neuroimaging Advisory Board of Prothena Biosciences. I.M-F is supported by the Spanish Ministry of Science, Innovation and Universities (JDC2022-049642-I). TLA is a Tier 1 Canada Research Chair in Healthy Aging. Funding for open access charge: Universidad de Granada / CBUA. Elsevier https://hdl.handle.net/10230/73373 http://dx.doi.org/10.1016/j.jsams.2025.04.011 |
| spellingShingle | Association of 24 h-movement behaviors with cerebral and hippocampal amyloid beta levels and executive function in cognitively normal older adults: a compositional data analysis from the AGUEDA trial Sclafani, Alessandro APOEε4 Accelerometers Alzheimer&apos s disease Cognitive function Dementia Positron emission tomography |
| status_str | publishedVersion |
| title | Association of 24 h-movement behaviors with cerebral and hippocampal amyloid beta levels and executive function in cognitively normal older adults: a compositional data analysis from the AGUEDA trial |
| title_full | Association of 24 h-movement behaviors with cerebral and hippocampal amyloid beta levels and executive function in cognitively normal older adults: a compositional data analysis from the AGUEDA trial |
| title_fullStr | Association of 24 h-movement behaviors with cerebral and hippocampal amyloid beta levels and executive function in cognitively normal older adults: a compositional data analysis from the AGUEDA trial |
| title_full_unstemmed | Association of 24 h-movement behaviors with cerebral and hippocampal amyloid beta levels and executive function in cognitively normal older adults: a compositional data analysis from the AGUEDA trial |
| title_short | Association of 24 h-movement behaviors with cerebral and hippocampal amyloid beta levels and executive function in cognitively normal older adults: a compositional data analysis from the AGUEDA trial |
| title_sort | Association of 24 h-movement behaviors with cerebral and hippocampal amyloid beta levels and executive function in cognitively normal older adults: a compositional data analysis from the AGUEDA trial |
| topic | APOEε4 Accelerometers Alzheimer&apos s disease Cognitive function Dementia Positron emission tomography |
| topic_facet | APOEε4 Accelerometers Alzheimer&apos s disease Cognitive function Dementia Positron emission tomography |
| url | https://hdl.handle.net/10230/73373 http://dx.doi.org/10.1016/j.jsams.2025.04.011 |