Development of Advanced 3D-Printed Solid Dosage Pediatric Formulations for HIV Treatment
The combination of lopinavir/ritonavir remains one of the first-line therapies for the initial antiretroviral regimen in pediatric HIV-infected children. However, the implementation of this recommendation has faced many challenges due to cold-chain requirements, high alcohol content, and unpalatabil...
| Authors: | ; ; ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2022 |
| Country: | España |
| Institution: | Universidad Complutense de Madrid (UCM) |
| Repository: | Docta Complutense |
| Language: | English |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/72526 |
| Online Access: | https://hdl.handle.net/20.500.14352/72526 |
| Access Level: | Open access |
| Keyword: | pediatric formulation ritonavir lopinavir minitablet 3D printing direct powder extrusion HIV FDM HME Inmunología Pediatría Farmacología (Farmacia) 2412 Inmunología 3201.10 Pediatría 3209 Farmacología |
| _version_ | 1878741380870701056 |
|---|---|
| author | Malebari, Azizah M. |
| author2 | Kara, Aytug Khayyat, Ahdab N. Mohammad, Khadijah A. Serrano López, Dolores Remedios |
| author2_role | author author author author |
| author_browse | Kara, Aytug Khayyat, Ahdab N. Malebari, Azizah M. Mohammad, Khadijah A. Serrano López, Dolores Remedios |
| author_facet | Malebari, Azizah M. Kara, Aytug Khayyat, Ahdab N. Mohammad, Khadijah A. Serrano López, Dolores Remedios |
| author_role | author |
| collection | Docta Complutense |
| description | The combination of lopinavir/ritonavir remains one of the first-line therapies for the initial antiretroviral regimen in pediatric HIV-infected children. However, the implementation of this recommendation has faced many challenges due to cold-chain requirements, high alcohol content, and unpalatability for ritonavir-boosted lopinavir syrup. In addition, the administration of crushed tablets has shown a detriment for the oral bioavailability of both drugs. Therefore, there is a clinical need to develop safer and better formulations adapted to children’s needs. This work has demonstrated, for the first time, the feasibility of using direct powder extrusion 3D printing to manufacture personalized pediatric HIV dosage forms based on 6 mm spherical tablets. H-bonding between drugs and excipients (hydroxypropyl methylcellulose and polyethylene glycol) resulted in the formation of amorphous solid dispersions with a zero-order sustained release profile, opposite to the commercially available formulation Kaletra, which exhibited marked drug precipitation at the intestinal pH. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_e42eea7df60c4f4e0a19b2b590f8e2a2 |
| institution | Universidad Complutense de Madrid (UCM) |
| instname_str | Universidad Complutense de Madrid (UCM) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:docta.ucm.es:20.500.14352/72526 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher | MPDI |
| publisherStr | MPDI |
| reponame_str | Docta Complutense |
| spelling | Development of Advanced 3D-Printed Solid Dosage Pediatric Formulations for HIV Treatment Malebari, Azizah M. Kara, Aytug Khayyat, Ahdab N. Mohammad, Khadijah A. Serrano López, Dolores Remedios pediatric formulation ritonavir lopinavir minitablet 3D printing direct powder extrusion HIV FDM HME Inmunología Pediatría Farmacología (Farmacia) 2412 Inmunología 3201.10 Pediatría 3209 Farmacología The combination of lopinavir/ritonavir remains one of the first-line therapies for the initial antiretroviral regimen in pediatric HIV-infected children. However, the implementation of this recommendation has faced many challenges due to cold-chain requirements, high alcohol content, and unpalatability for ritonavir-boosted lopinavir syrup. In addition, the administration of crushed tablets has shown a detriment for the oral bioavailability of both drugs. Therefore, there is a clinical need to develop safer and better formulations adapted to children’s needs. This work has demonstrated, for the first time, the feasibility of using direct powder extrusion 3D printing to manufacture personalized pediatric HIV dosage forms based on 6 mm spherical tablets. H-bonding between drugs and excipients (hydroxypropyl methylcellulose and polyethylene glycol) resulted in the formation of amorphous solid dispersions with a zero-order sustained release profile, opposite to the commercially available formulation Kaletra, which exhibited marked drug precipitation at the intestinal pH. MPDI https://hdl.handle.net/20.500.14352/72526 |
| spellingShingle | Development of Advanced 3D-Printed Solid Dosage Pediatric Formulations for HIV Treatment Malebari, Azizah M. pediatric formulation ritonavir lopinavir minitablet 3D printing direct powder extrusion HIV FDM HME Inmunología Pediatría Farmacología (Farmacia) 2412 Inmunología 3201.10 Pediatría 3209 Farmacología |
| title | Development of Advanced 3D-Printed Solid Dosage Pediatric Formulations for HIV Treatment |
| title_full | Development of Advanced 3D-Printed Solid Dosage Pediatric Formulations for HIV Treatment |
| title_fullStr | Development of Advanced 3D-Printed Solid Dosage Pediatric Formulations for HIV Treatment |
| title_full_unstemmed | Development of Advanced 3D-Printed Solid Dosage Pediatric Formulations for HIV Treatment |
| title_short | Development of Advanced 3D-Printed Solid Dosage Pediatric Formulations for HIV Treatment |
| title_sort | Development of Advanced 3D-Printed Solid Dosage Pediatric Formulations for HIV Treatment |
| topic | pediatric formulation ritonavir lopinavir minitablet 3D printing direct powder extrusion HIV FDM HME Inmunología Pediatría Farmacología (Farmacia) 2412 Inmunología 3201.10 Pediatría 3209 Farmacología |
| topic_facet | pediatric formulation ritonavir lopinavir minitablet 3D printing direct powder extrusion HIV FDM HME Inmunología Pediatría Farmacología (Farmacia) 2412 Inmunología 3201.10 Pediatría 3209 Farmacología |
| url | https://hdl.handle.net/20.500.14352/72526 |