Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review
Introduction: Enterococcus faecium is a commensal microorganism that can cause infections such as bacteremia. Incidence of ampicillin-resistant and vancomycin-susceptible E. faecium (EfARSV) bacteremia is on the rise, and the mortality rate is high. Despite much data, the most appropriate treatment...
| Authors: | ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Accepted version |
| Publication date: | 2023 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/60151 |
| Online Access: | http://hdl.handle.net/10230/60151 http://dx.doi.org/10.1080/14787210.2023.2223977 |
| Access Level: | Open access |
| Keyword: | Bacteremia Enterococcus faecium Bloodstream infection Daptomycin Linezolid Oritavancin Teicoplanin Vancomycin |
| _version_ | 1878741361941807104 |
|---|---|
| author | Echeverría Esnal, Daniel |
| author2 | Sorli Redó, M. Luisa Navarrete Rouco, Maria Eugenia Prim, Núria Barceló-Vidal, Jaime Conde Estévez, David Milagro Montero, Maria Martín-Ontiyuelo, Clara Horcajada Gallego, Juan Pablo Grau Cerrato, Santiago |
| author2_role | author author author author author author author author author |
| author_browse | Barceló-Vidal, Jaime Conde Estévez, David Echeverría Esnal, Daniel Grau Cerrato, Santiago Horcajada Gallego, Juan Pablo Martín-Ontiyuelo, Clara Milagro Montero, Maria Navarrete Rouco, Maria Eugenia Prim, Núria Sorli Redó, M. Luisa |
| author_facet | Echeverría Esnal, Daniel Sorli Redó, M. Luisa Navarrete Rouco, Maria Eugenia Prim, Núria Barceló-Vidal, Jaime Conde Estévez, David Milagro Montero, Maria Martín-Ontiyuelo, Clara Horcajada Gallego, Juan Pablo Grau Cerrato, Santiago |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Introduction: Enterococcus faecium is a commensal microorganism that can cause infections such as bacteremia. Incidence of ampicillin-resistant and vancomycin-susceptible E. faecium (EfARSV) bacteremia is on the rise, and the mortality rate is high. Despite much data, the most appropriate treatment remains a question. Areas covered: This article mostly reviews the relevant aspects of EfARSV bacteremia: microbiology, gastrointestinal tract colonization and invasion, antibiotic resistance, epidemiology, risk factors, mortality, and treatment, including pharmacologic components of employed agents and related clinical evidence. A literature search was conducted on PubMed on 31 July 2022, which was updated on 15 November 2022. Expert opinion: EfARSV bacteremia presents high mortality. However, it is uncertain whether mortality is attributable to or a marker of severity/comorbidities. Considering its antibiotic resistance pattern, EfARSV is considered a difficult-to-treat microorganism. Glycopeptides have been used to treat EfARSV, with linezolid and daptomycin serving as potential alternative agents. Yet, the use of daptomycin is controversial due to a higher risk of treatment failures. Clinical evidence on this issue is scarce, unfortunately, and subject to many limitations. Despite increased incidence and mortality, EfARSV bacteremia presents multiple aspects to be addressed in well-conducted studies. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_e3d2c0ceab2bc476b08d2e97dd5f2dcb |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:10230/60151 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher | Taylor & Francis |
| publisherStr | Taylor & Francis |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review Echeverría Esnal, Daniel Sorli Redó, M. Luisa Navarrete Rouco, Maria Eugenia Prim, Núria Barceló-Vidal, Jaime Conde Estévez, David Milagro Montero, Maria Martín-Ontiyuelo, Clara Horcajada Gallego, Juan Pablo Grau Cerrato, Santiago Bacteremia Enterococcus faecium Bloodstream infection Daptomycin Linezolid Oritavancin Teicoplanin Vancomycin Introduction: Enterococcus faecium is a commensal microorganism that can cause infections such as bacteremia. Incidence of ampicillin-resistant and vancomycin-susceptible E. faecium (EfARSV) bacteremia is on the rise, and the mortality rate is high. Despite much data, the most appropriate treatment remains a question. Areas covered: This article mostly reviews the relevant aspects of EfARSV bacteremia: microbiology, gastrointestinal tract colonization and invasion, antibiotic resistance, epidemiology, risk factors, mortality, and treatment, including pharmacologic components of employed agents and related clinical evidence. A literature search was conducted on PubMed on 31 July 2022, which was updated on 15 November 2022. Expert opinion: EfARSV bacteremia presents high mortality. However, it is uncertain whether mortality is attributable to or a marker of severity/comorbidities. Considering its antibiotic resistance pattern, EfARSV is considered a difficult-to-treat microorganism. Glycopeptides have been used to treat EfARSV, with linezolid and daptomycin serving as potential alternative agents. Yet, the use of daptomycin is controversial due to a higher risk of treatment failures. Clinical evidence on this issue is scarce, unfortunately, and subject to many limitations. Despite increased incidence and mortality, EfARSV bacteremia presents multiple aspects to be addressed in well-conducted studies. Taylor & Francis http://hdl.handle.net/10230/60151 http://dx.doi.org/10.1080/14787210.2023.2223977 |
| spellingShingle | Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review Echeverría Esnal, Daniel Bacteremia Enterococcus faecium Bloodstream infection Daptomycin Linezolid Oritavancin Teicoplanin Vancomycin |
| status_str | acceptedVersion |
| title | Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review |
| title_full | Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review |
| title_fullStr | Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review |
| title_full_unstemmed | Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review |
| title_short | Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review |
| title_sort | Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review |
| topic | Bacteremia Enterococcus faecium Bloodstream infection Daptomycin Linezolid Oritavancin Teicoplanin Vancomycin |
| topic_facet | Bacteremia Enterococcus faecium Bloodstream infection Daptomycin Linezolid Oritavancin Teicoplanin Vancomycin |
| url | http://hdl.handle.net/10230/60151 http://dx.doi.org/10.1080/14787210.2023.2223977 |