Physical activity is directly associated with total energy expenditure without evidence of constraint or compensation
The prevailing linear model of physical activity (PA) and total energy expenditure (TEE) has been challenged by models that predict an upper limit of TEE linked to a compensatory reduction elsewhere in the energy budget in response to increased PA. We determined the equation of best fit between PA a...
| Autores: | ; ; ; ; ; ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad de Burgos (UBU) |
| Repositorio: | Repositorio Institucional de la Universidad de Burgos (RIUBU) |
| OAI Identifier: | oai:riubu.ubu.es:10259/11212 |
| Acceso en línea: | https://hdl.handle.net/10259/11212 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Physical activity Energy expenditure Doubly-labelled water Constraint Compensation Fisiología humana Ejercicio físico Metabolismo energético Human physiology Exercise Energy metabolism |
| _version_ | 1878741361888329728 |
|---|---|
| author | Howard, Kristen R. |
| author2 | Prado‐Nóvoa, Olalla Zorrilla Revilla, Guillermo Laskaridou, Eleni Reid, Glen R. Marinik, Elaina L. Stamatiou, Marina Hambly, Catherine Davy, Brenda M. Speakman, John R. Davy, Kevin P. |
| author2_role | author author author author author author author author author author |
| author_browse | Davy, Brenda M. Davy, Kevin P. Hambly, Catherine Howard, Kristen R. Laskaridou, Eleni Marinik, Elaina L. Prado‐Nóvoa, Olalla Reid, Glen R. Speakman, John R. Stamatiou, Marina Zorrilla Revilla, Guillermo |
| author_facet | Howard, Kristen R. Prado‐Nóvoa, Olalla Zorrilla Revilla, Guillermo Laskaridou, Eleni Reid, Glen R. Marinik, Elaina L. Stamatiou, Marina Hambly, Catherine Davy, Brenda M. Speakman, John R. Davy, Kevin P. |
| author_role | author |
| collection | Repositorio Institucional de la Universidad de Burgos (RIUBU) |
| description | The prevailing linear model of physical activity (PA) and total energy expenditure (TEE) has been challenged by models that predict an upper limit of TEE linked to a compensatory reduction elsewhere in the energy budget in response to increased PA. We determined the equation of best fit between PA and TEE and explored relationships between PA and behavioral and physiological compensation. Using linear and nonlinear modeling, we observed a positive linear relationship between PA and TEE either without or after adjustment for fat-free mass (R2= 0.3492, TEE = 0.00685*PA + 7.124: R2=0.3667, TEE_ADJ(FFM) = 0.00511*PA + 8.598). Higher PA was associated with lower sedentary time (R2= 0.7207, %SPA= −0.0211*X + 91.261). There was no association between PA, TEE, or resting metabolic rate and adjusted biomarkers of immune, reproductive, or thyroid function after Bonferroni correction. The findings of this observational study do not support the constrained/compensated model but affirm the conventional additive relationship between PA and TEE across a broad range of PA levels. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_e3d0fc4a9c48dcb4e43dd1eac03e9bc0 |
| institution | Universidad de Burgos (UBU) |
| instname_str | Universidad de Burgos (UBU) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:riubu.ubu.es:10259/11212 |
| publishDate | 2025 |
| publishDateSort | 2025 |
| publisher | National Academy of Sciences |
| publisherStr | National Academy of Sciences |
| reponame_str | Repositorio Institucional de la Universidad de Burgos (RIUBU) |
| spelling | Physical activity is directly associated with total energy expenditure without evidence of constraint or compensation Howard, Kristen R. Prado‐Nóvoa, Olalla Zorrilla Revilla, Guillermo Laskaridou, Eleni Reid, Glen R. Marinik, Elaina L. Stamatiou, Marina Hambly, Catherine Davy, Brenda M. Speakman, John R. Davy, Kevin P. Physical activity Energy expenditure Doubly-labelled water Constraint Compensation Fisiología humana Ejercicio físico Metabolismo energético Human physiology Exercise Energy metabolism The prevailing linear model of physical activity (PA) and total energy expenditure (TEE) has been challenged by models that predict an upper limit of TEE linked to a compensatory reduction elsewhere in the energy budget in response to increased PA. We determined the equation of best fit between PA and TEE and explored relationships between PA and behavioral and physiological compensation. Using linear and nonlinear modeling, we observed a positive linear relationship between PA and TEE either without or after adjustment for fat-free mass (R2= 0.3492, TEE = 0.00685*PA + 7.124: R2=0.3667, TEE_ADJ(FFM) = 0.00511*PA + 8.598). Higher PA was associated with lower sedentary time (R2= 0.7207, %SPA= −0.0211*X + 91.261). There was no association between PA, TEE, or resting metabolic rate and adjusted biomarkers of immune, reproductive, or thyroid function after Bonferroni correction. The findings of this observational study do not support the constrained/compensated model but affirm the conventional additive relationship between PA and TEE across a broad range of PA levels. K.R.H. is funded by a Virginia Tech Translational Obesity Research Interdisciplinary Graduate Education Predoctoral Fellowship, O.P.-N. is funded by a Virginia Tech Presidential Postdoctoral Fellowship, and G.Z.-R. is funded by Next Generation European Union funds Margarita Salas Postdoctoral Fellowship. National Academy of Sciences https://hdl.handle.net/10259/11212 |
| spellingShingle | Physical activity is directly associated with total energy expenditure without evidence of constraint or compensation Howard, Kristen R. Physical activity Energy expenditure Doubly-labelled water Constraint Compensation Fisiología humana Ejercicio físico Metabolismo energético Human physiology Exercise Energy metabolism |
| status_str | publishedVersion |
| title | Physical activity is directly associated with total energy expenditure without evidence of constraint or compensation |
| title_full | Physical activity is directly associated with total energy expenditure without evidence of constraint or compensation |
| title_fullStr | Physical activity is directly associated with total energy expenditure without evidence of constraint or compensation |
| title_full_unstemmed | Physical activity is directly associated with total energy expenditure without evidence of constraint or compensation |
| title_short | Physical activity is directly associated with total energy expenditure without evidence of constraint or compensation |
| title_sort | Physical activity is directly associated with total energy expenditure without evidence of constraint or compensation |
| topic | Physical activity Energy expenditure Doubly-labelled water Constraint Compensation Fisiología humana Ejercicio físico Metabolismo energético Human physiology Exercise Energy metabolism |
| topic_facet | Physical activity Energy expenditure Doubly-labelled water Constraint Compensation Fisiología humana Ejercicio físico Metabolismo energético Human physiology Exercise Energy metabolism |
| url | https://hdl.handle.net/10259/11212 |