Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study.
: To assess oxidative-inflammatory biomarker prediction of incident CKD after 1-year follow-up in a population with overweight/obesity and metabolic syndrome. : Prospective nested case-control study comprising 117 CKD incident cases and 117 matched controls free of CKD after 1-year follow-up conduct...
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| Format: | Article |
| Publication date: | 2025 |
| Country: | España |
| Institution: | Conselleria de Salut i Consum del Govern de les Illes Balears |
| Repository: | Docusalut |
| Language: | English |
| OAI Identifier: | oai:docusalut.com:20.500.13003/25897 |
| Online Access: | https://hdl.handle.net/20.500.13003/25897 |
| Access Level: | Open access |
| Keyword: | Glomerular Filtration Rate Glomerular Filtration Barrier Inflammation Kidney Metabolic Syndrome Oxidative Stress Tasa de Filtración Glomerular Barrera de Filtración Glomerular Inflamación Riñón Síndrome Metabólico Estrés Oxidativo glomerular filtration inflammation kidney dysfunction metabolic syndrome oxidative stress |
| _version_ | 1878741307704213504 |
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| author | Quetglas-Llabrés, Maria Magdalena |
| author2 | Díaz-López, Andrés Bouzas, Cristina Monserrat Mesquida, Margalida Salas-Salvadó, Jordi Ruiz-Canela, Miguel Martínez, J Alfredo Santos-Lozano, José Manuel García, Silvia Estruch, Ramon López-Miranda, José Romaguera, Dora Tinahones, Francisco J García-Fernández, Marcos Mas-Fontao, Sebastián Matía-Martín, Pilar Vioque, Jesús Bueno, Aurora Babio, Nancy Tur, Josep A. Sureda, Antoni |
| author2_role | author author author author author author author author author author author author author author author author author author author author |
| author_browse | Babio, Nancy Bouzas, Cristina Bueno, Aurora Díaz-López, Andrés Estruch, Ramon García, Silvia García-Fernández, Marcos López-Miranda, José Martínez, J Alfredo Mas-Fontao, Sebastián Matía-Martín, Pilar Monserrat Mesquida, Margalida Quetglas-Llabrés, Maria Magdalena Romaguera, Dora Ruiz-Canela, Miguel Salas-Salvadó, Jordi Santos-Lozano, José Manuel Sureda, Antoni Tinahones, Francisco J Tur, Josep A. Vioque, Jesús |
| author_facet | Quetglas-Llabrés, Maria Magdalena Díaz-López, Andrés Bouzas, Cristina Monserrat Mesquida, Margalida Salas-Salvadó, Jordi Ruiz-Canela, Miguel Martínez, J Alfredo Santos-Lozano, José Manuel García, Silvia Estruch, Ramon López-Miranda, José Romaguera, Dora Tinahones, Francisco J García-Fernández, Marcos Mas-Fontao, Sebastián Matía-Martín, Pilar Vioque, Jesús Bueno, Aurora Babio, Nancy Tur, Josep A. Sureda, Antoni |
| author_role | author |
| collection | Docusalut |
| description | : To assess oxidative-inflammatory biomarker prediction of incident CKD after 1-year follow-up in a population with overweight/obesity and metabolic syndrome. : Prospective nested case-control study comprising 117 CKD incident cases and 117 matched controls free of CKD after 1-year follow-up conducted in 55-75-year-old participants. Controls were time-matched 1:1 to cases by intervention group, age (≤65 vs. >65 years), and sex. Serum creatinine (SCr), cystatin C (CyC), and urine albumin-to-creatinine ratio (UACR) were measured at baseline, and CKD Epidemiology Collaboration equations for Caucasians were used to assess SCr, CyC, and CyC-SCr-based estimated Glomerular Filtration Rate (eGFR). Baseline levels of malondialdehyde (MDA), carbonyls, tumour necrosis factor alpha (TNFα), interleukin (IL)-1β, IL-1ra, IL-6, monocyte chemoattractant protein 1 (MCP-1), and leptin were determined from fasting serum samples. An inflammatory-oxidative stress score based on these biomarkers was calculated. Incident CKD was defined by eGFR-SCr <60 mL/min/1.73 m, and/or UACR ≥30 mg/g in the absence of CKD at baseline. : UACR positively correlated with pro-inflammatory markers (IL-1β; TNFα) and oxidative damage marker (MDA); eGFR-cyC showed negative correlations with IL-1β and IL-1ra, and eGFR-SCr with leptin. The odds ratios (OR; 95% CI) for incident CKD in the highest vs. the lowest tertile of IL-1ra IL-6 and TNFα were (2.22; 1.22-4.04), (7.03; 2.88-17.14), and (3.79; 1.79-8.02), respectively. The inflammatory-oxidative stress score was associated with incident CKD (OR per 1-SD increment: 2.06; 1.49-2.83). : Inflammatory/oxidative stress is associated with CKD incidence in individuals with high cardiovascular risk, underscoring the importance in identify early inflammation to prevent this disease. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_e2e43f06d6ea491cfe5ebe689ecfdc3e |
| institution | Conselleria de Salut i Consum del Govern de les Illes Balears |
| instname_str | Conselleria de Salut i Consum del Govern de les Illes Balears |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:docusalut.com:20.500.13003/25897 |
| publishDate | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI |
| publisherStr | MDPI |
| reponame_str | Docusalut |
| spelling | Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study. Quetglas-Llabrés, Maria Magdalena Díaz-López, Andrés Bouzas, Cristina Monserrat Mesquida, Margalida Salas-Salvadó, Jordi Ruiz-Canela, Miguel Martínez, J Alfredo Santos-Lozano, José Manuel García, Silvia Estruch, Ramon López-Miranda, José Romaguera, Dora Tinahones, Francisco J García-Fernández, Marcos Mas-Fontao, Sebastián Matía-Martín, Pilar Vioque, Jesús Bueno, Aurora Babio, Nancy Tur, Josep A. Sureda, Antoni Glomerular Filtration Rate Glomerular Filtration Barrier Inflammation Kidney Metabolic Syndrome Oxidative Stress Tasa de Filtración Glomerular Barrera de Filtración Glomerular Inflamación Riñón Síndrome Metabólico Estrés Oxidativo glomerular filtration inflammation kidney dysfunction metabolic syndrome oxidative stress : To assess oxidative-inflammatory biomarker prediction of incident CKD after 1-year follow-up in a population with overweight/obesity and metabolic syndrome. : Prospective nested case-control study comprising 117 CKD incident cases and 117 matched controls free of CKD after 1-year follow-up conducted in 55-75-year-old participants. Controls were time-matched 1:1 to cases by intervention group, age (≤65 vs. >65 years), and sex. Serum creatinine (SCr), cystatin C (CyC), and urine albumin-to-creatinine ratio (UACR) were measured at baseline, and CKD Epidemiology Collaboration equations for Caucasians were used to assess SCr, CyC, and CyC-SCr-based estimated Glomerular Filtration Rate (eGFR). Baseline levels of malondialdehyde (MDA), carbonyls, tumour necrosis factor alpha (TNFα), interleukin (IL)-1β, IL-1ra, IL-6, monocyte chemoattractant protein 1 (MCP-1), and leptin were determined from fasting serum samples. An inflammatory-oxidative stress score based on these biomarkers was calculated. Incident CKD was defined by eGFR-SCr <60 mL/min/1.73 m, and/or UACR ≥30 mg/g in the absence of CKD at baseline. : UACR positively correlated with pro-inflammatory markers (IL-1β; TNFα) and oxidative damage marker (MDA); eGFR-cyC showed negative correlations with IL-1β and IL-1ra, and eGFR-SCr with leptin. The odds ratios (OR; 95% CI) for incident CKD in the highest vs. the lowest tertile of IL-1ra IL-6 and TNFα were (2.22; 1.22-4.04), (7.03; 2.88-17.14), and (3.79; 1.79-8.02), respectively. The inflammatory-oxidative stress score was associated with incident CKD (OR per 1-SD increment: 2.06; 1.49-2.83). : Inflammatory/oxidative stress is associated with CKD incidence in individuals with high cardiovascular risk, underscoring the importance in identify early inflammation to prevent this disease. MDPI https://hdl.handle.net/20.500.13003/25897 |
| spellingShingle | Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study. Quetglas-Llabrés, Maria Magdalena Glomerular Filtration Rate Glomerular Filtration Barrier Inflammation Kidney Metabolic Syndrome Oxidative Stress Tasa de Filtración Glomerular Barrera de Filtración Glomerular Inflamación Riñón Síndrome Metabólico Estrés Oxidativo glomerular filtration inflammation kidney dysfunction metabolic syndrome oxidative stress |
| title | Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study. |
| title_full | Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study. |
| title_fullStr | Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study. |
| title_full_unstemmed | Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study. |
| title_short | Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study. |
| title_sort | Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study. |
| topic | Glomerular Filtration Rate Glomerular Filtration Barrier Inflammation Kidney Metabolic Syndrome Oxidative Stress Tasa de Filtración Glomerular Barrera de Filtración Glomerular Inflamación Riñón Síndrome Metabólico Estrés Oxidativo glomerular filtration inflammation kidney dysfunction metabolic syndrome oxidative stress |
| topic_facet | Glomerular Filtration Rate Glomerular Filtration Barrier Inflammation Kidney Metabolic Syndrome Oxidative Stress Tasa de Filtración Glomerular Barrera de Filtración Glomerular Inflamación Riñón Síndrome Metabólico Estrés Oxidativo glomerular filtration inflammation kidney dysfunction metabolic syndrome oxidative stress |
| url | https://hdl.handle.net/20.500.13003/25897 |