Mechanics-driven mechanobiological mechanisms of arterial tortuosity
[EN] Arterial tortuosity manifests in many conditions, including hypertension, genetic mutations predisposing to thoracic aortopathy, and vascular aging. Despite evidence that tortuosity disrupts efficient blood flow and that it may be an important clinical biomarker, underlying mechanisms remain po...
| Authors: | ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2020 |
| Country: | España |
| Institution: | Universitat Politècnica de València (UPV) |
| Repository: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Language: | English |
| OAI Identifier: | oai:riunet.upv.es:10251/191511 |
| Online Access: | https://riunet.upv.es/handle/10251/191511 |
| Access Level: | Open access |
| Keyword: | Tortuosity 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades |
| _version_ | 1878741303551852544 |
|---|---|
| author | Weiss, Dar |
| author2 | Cavinato, Cristina Gray, Authia Ramachandra, Abhay B. Avril, Stephane Humphrey, Jay D. Latorre, Marcos|||0000-0003-4142-0207 |
| author2_role | author author author author author author |
| author_browse | Avril, Stephane Cavinato, Cristina Gray, Authia Humphrey, Jay D. Latorre, Marcos|||0000-0003-4142-0207 Ramachandra, Abhay B. Weiss, Dar |
| author_facet | Weiss, Dar Cavinato, Cristina Gray, Authia Ramachandra, Abhay B. Avril, Stephane Humphrey, Jay D. Latorre, Marcos|||0000-0003-4142-0207 |
| author_role | author |
| collection | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| description | [EN] Arterial tortuosity manifests in many conditions, including hypertension, genetic mutations predisposing to thoracic aortopathy, and vascular aging. Despite evidence that tortuosity disrupts efficient blood flow and that it may be an important clinical biomarker, underlying mechanisms remain poorly understood but are widely appreciated to be largely biomechanical. Many previous studies suggested that tortuosity may arise via an elastic structural buckling instability, but the novel experimental-computational approach used here suggests that tortuosity arises from mechanosensitive, cell-mediated responses to local aberrations in the microstructural integrity of the arterial wall. In particular, computations informed by multimodality imaging show that aberrations in elastic fiber integrity, collagen alignment, and collagen turnover can lead to a progressive loss of structural stability that entrenches during the development of tortuosity. Interpreted in this way, microstructural defects or irregularities of the arterial wall initiate the condition and hypertension is a confounding factor. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_e2c76db36a6f23d2ea2cb9f63efaee8b |
| institution | Universitat Politècnica de València (UPV) |
| instname_str | Universitat Politècnica de València (UPV) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:riunet.upv.es:10251/191511 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher | American Association for the Advancement of Science |
| publisherStr | American Association for the Advancement of Science |
| reponame_str | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| spelling | Mechanics-driven mechanobiological mechanisms of arterial tortuosity Weiss, Dar Cavinato, Cristina Gray, Authia Ramachandra, Abhay B. Avril, Stephane Humphrey, Jay D. Latorre, Marcos|||0000-0003-4142-0207 Tortuosity 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades [EN] Arterial tortuosity manifests in many conditions, including hypertension, genetic mutations predisposing to thoracic aortopathy, and vascular aging. Despite evidence that tortuosity disrupts efficient blood flow and that it may be an important clinical biomarker, underlying mechanisms remain poorly understood but are widely appreciated to be largely biomechanical. Many previous studies suggested that tortuosity may arise via an elastic structural buckling instability, but the novel experimental-computational approach used here suggests that tortuosity arises from mechanosensitive, cell-mediated responses to local aberrations in the microstructural integrity of the arterial wall. In particular, computations informed by multimodality imaging show that aberrations in elastic fiber integrity, collagen alignment, and collagen turnover can lead to a progressive loss of structural stability that entrenches during the development of tortuosity. Interpreted in this way, microstructural defects or irregularities of the arterial wall initiate the condition and hypertension is a confounding factor. This work was supported by grants from the U.S. NIH (R01 HL105297, P01 HL134605, and U01 HL142518) American Association for the Advancement of Science https://riunet.upv.es/handle/10251/191511 |
| spellingShingle | Mechanics-driven mechanobiological mechanisms of arterial tortuosity Weiss, Dar Tortuosity 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades |
| title | Mechanics-driven mechanobiological mechanisms of arterial tortuosity |
| title_full | Mechanics-driven mechanobiological mechanisms of arterial tortuosity |
| title_fullStr | Mechanics-driven mechanobiological mechanisms of arterial tortuosity |
| title_full_unstemmed | Mechanics-driven mechanobiological mechanisms of arterial tortuosity |
| title_short | Mechanics-driven mechanobiological mechanisms of arterial tortuosity |
| title_sort | Mechanics-driven mechanobiological mechanisms of arterial tortuosity |
| topic | Tortuosity 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades |
| topic_facet | Tortuosity 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades |
| url | https://riunet.upv.es/handle/10251/191511 |