Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity
Cardiorenal syndrome (CRS) represents a complex pathological interaction between the heart and the kidneys, where acute or chronic injury in one of them induces acute or chronic damage in the other. Out of the five subtypes, CRS type 1 (CRS-1), which is characterized by the worsening of cardiac func...
| Autor: | |
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| Tipo de documento: | Tesis doctoral |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/119052 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/119052 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | 616.61(043.2) Galectina Nefrología y urología 3205.06 Nefrología |
| _version_ | 1878741051057897472 |
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| author | Delgado Valero, Beatriz |
| author_browse | Delgado Valero, Beatriz |
| author_facet | Delgado Valero, Beatriz |
| author_role | author |
| collection | Docta Complutense |
| description | Cardiorenal syndrome (CRS) represents a complex pathological interaction between the heart and the kidneys, where acute or chronic injury in one of them induces acute or chronic damage in the other. Out of the five subtypes, CRS type 1 (CRS-1), which is characterized by the worsening of cardiac function leading to acute kidney injury [1], is known to have the highest incidence among the CRS diagnosed patients [2, 3]. Moreover, development of CRS-1 is known to increase hospitalization times and complicate clinical outcome in patients [4, 5].Although traditional cardiovascular risk factors such as hypertension, obesity or diabetes are believed to be implicated in the shared pathology of the heart and the kidneys, targeting only these factors in CRS-1 has shown unsatisfactory results [6], suggesting the need to assess non-conventional risk factors and other underlying mechanisms that could be relevant in the pathophysiology of CRS-induced renal damage... |
| eu_rights_str_mv | openAccess |
| format | doctoralThesis |
| id | ES_de3255f8ced0f55ea46cf43bc626b903 |
| institution | Universidad Complutense de Madrid (UCM) |
| instname_str | Universidad Complutense de Madrid (UCM) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:docta.ucm.es:20.500.14352/119052 |
| publishDate | 2025 |
| publishDateSort | 2025 |
| publisher | Universidad Complutense de Madrid |
| publisherStr | Universidad Complutense de Madrid |
| reponame_str | Docta Complutense |
| spelling | Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity La Galectina-3 promueve la activación del estrés de retículo endoplásmico a través de la disminución de let-7f-5p: relevancia en el daño renal post-infarto de miocardio en el contexto de la obesidad Delgado Valero, Beatriz 616.61(043.2) Galectina Nefrología y urología 3205.06 Nefrología Cardiorenal syndrome (CRS) represents a complex pathological interaction between the heart and the kidneys, where acute or chronic injury in one of them induces acute or chronic damage in the other. Out of the five subtypes, CRS type 1 (CRS-1), which is characterized by the worsening of cardiac function leading to acute kidney injury [1], is known to have the highest incidence among the CRS diagnosed patients [2, 3]. Moreover, development of CRS-1 is known to increase hospitalization times and complicate clinical outcome in patients [4, 5].Although traditional cardiovascular risk factors such as hypertension, obesity or diabetes are believed to be implicated in the shared pathology of the heart and the kidneys, targeting only these factors in CRS-1 has shown unsatisfactory results [6], suggesting the need to assess non-conventional risk factors and other underlying mechanisms that could be relevant in the pathophysiology of CRS-induced renal damage... Universidad Complutense de Madrid https://hdl.handle.net/20.500.14352/119052 |
| spellingShingle | Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity Delgado Valero, Beatriz 616.61(043.2) Galectina Nefrología y urología 3205.06 Nefrología |
| title | Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity |
| title_full | Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity |
| title_fullStr | Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity |
| title_full_unstemmed | Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity |
| title_short | Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity |
| title_sort | Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity |
| topic | 616.61(043.2) Galectina Nefrología y urología 3205.06 Nefrología |
| topic_facet | 616.61(043.2) Galectina Nefrología y urología 3205.06 Nefrología |
| url | https://hdl.handle.net/20.500.14352/119052 |