Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds
Recent studies suggest that misfolded tau molecules can be released, and taken up by adjacent neurons, propagating proteopathic seeds across neural systems. Yet critical to understanding whether tau propagation is relevant in pathophysiology of disease would be to learn if it alters neuronal propert...
| Authors: | ; ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2020 |
| Country: | España |
| Institution: | INCLIVA |
| Repository: | r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
| OAI Identifier: | oai:incliva.fundanetsuite.com:p15264 |
| Online Access: | https://incliva.portalinvestigacion.com/publicaciones/15264 |
| Access Level: | Open access |
| Keyword: | Alzheimer's disease Neurofibrillary tangles Tau seeding RNA expression |
| _version_ | 1878740974270676992 |
|---|---|
| author | Perez-Rando, M |
| author2 | Dujardin, S Bennett, RE Commins, C Nibhanupudy, T Hyman, BT |
| author2_role | author author author author author |
| author_browse | Bennett, RE Commins, C Dujardin, S Hyman, BT Nibhanupudy, T Perez-Rando, M |
| author_facet | Perez-Rando, M Dujardin, S Bennett, RE Commins, C Nibhanupudy, T Hyman, BT |
| author_role | author |
| collection | r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
| description | Recent studies suggest that misfolded tau molecules can be released, and taken up by adjacent neurons, propagating proteopathic seeds across neural systems. Yet critical to understanding whether tau propagation is relevant in pathophysiology of disease would be to learn if it alters neuronal properties. We utilized high resolution multi-color in situ hybridization technology, RNAScope, in a well-established tau transgenic animal, and found that a subset of neurons in the cortex do not appear to express the transgene, but do develop phospho-tau positive inclusions, consistent with having received tau seeds. Recipient neurons show decreases in their expression of synaptophysin, CAMKII alpha, and mouse tau in both young and old animals. These results contrast with neurons that develop tau aggregates and also overexpress the transgene, which have few changes in expression of metabolic and synaptic markers. Taken together, these results strongly suggest that tau propagation impacts neuronal functional integrity. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_dcc5dbe4bf5dc052d5122a521f84a659 |
| institution | INCLIVA |
| instname_str | INCLIVA |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:incliva.fundanetsuite.com:p15264 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher | BMC |
| publisherStr | BMC |
| reponame_str | r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
| spelling | Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds Perez-Rando, M Dujardin, S Bennett, RE Commins, C Nibhanupudy, T Hyman, BT Alzheimer's disease Neurofibrillary tangles Tau seeding RNA expression Recent studies suggest that misfolded tau molecules can be released, and taken up by adjacent neurons, propagating proteopathic seeds across neural systems. Yet critical to understanding whether tau propagation is relevant in pathophysiology of disease would be to learn if it alters neuronal properties. We utilized high resolution multi-color in situ hybridization technology, RNAScope, in a well-established tau transgenic animal, and found that a subset of neurons in the cortex do not appear to express the transgene, but do develop phospho-tau positive inclusions, consistent with having received tau seeds. Recipient neurons show decreases in their expression of synaptophysin, CAMKII alpha, and mouse tau in both young and old animals. These results contrast with neurons that develop tau aggregates and also overexpress the transgene, which have few changes in expression of metabolic and synaptic markers. Taken together, these results strongly suggest that tau propagation impacts neuronal functional integrity. BMC https://incliva.portalinvestigacion.com/publicaciones/15264 |
| spellingShingle | Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds Perez-Rando, M Alzheimer's disease Neurofibrillary tangles Tau seeding RNA expression |
| status_str | publishedVersion |
| title | Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds |
| title_full | Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds |
| title_fullStr | Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds |
| title_full_unstemmed | Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds |
| title_short | Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds |
| title_sort | Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds |
| topic | Alzheimer's disease Neurofibrillary tangles Tau seeding RNA expression |
| topic_facet | Alzheimer's disease Neurofibrillary tangles Tau seeding RNA expression |
| url | https://incliva.portalinvestigacion.com/publicaciones/15264 |