Harnessing landrace diversity empowers wheat breeding
Harnessing genetic diversity in major staple crops through the development of new breeding capabilities is essential to ensure food security1. Here we examined the genetic and phenotypic diversity of the A. E. Watkins landrace collection2 of bread wheat (Triticum aestivum), a major global cereal, by...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2024 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10459.1/466820 |
| Online Access: | https://doi.org/10.1038/s41586-024-07682-9 https://hdl.handle.net/10459.1/466820 |
| Access Level: | Open access |
| Keyword: | Alleles Crops, Agricultural Genetic Introgression Genetic Variation Genome, Plant |
| _version_ | 1878740943035695104 |
|---|---|
| author | Cheng, Shifeng |
| author2 | Feng, Cong Wingen, Luzie U. Cheng, Hong Riche, Andrew B. Jiang, Mei Leverington-Waite, Michelle Huang, Zejian Collier, Sarah Orford, Simon Wang, Xiaoming Awal, Rajani Barker, Gary O’Hara, Tom Lister, Clare Bicego, Breno |
| author2_role | author author author author author author author author author author author author author author author |
| author_browse | Awal, Rajani Barker, Gary Bicego, Breno Cheng, Hong Cheng, Shifeng Collier, Sarah Feng, Cong Huang, Zejian Jiang, Mei Leverington-Waite, Michelle Lister, Clare Orford, Simon O’Hara, Tom Riche, Andrew B. Wang, Xiaoming Wingen, Luzie U. |
| author_facet | Cheng, Shifeng Feng, Cong Wingen, Luzie U. Cheng, Hong Riche, Andrew B. Jiang, Mei Leverington-Waite, Michelle Huang, Zejian Collier, Sarah Orford, Simon Wang, Xiaoming Awal, Rajani Barker, Gary O’Hara, Tom Lister, Clare Bicego, Breno |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Harnessing genetic diversity in major staple crops through the development of new breeding capabilities is essential to ensure food security1. Here we examined the genetic and phenotypic diversity of the A. E. Watkins landrace collection2 of bread wheat (Triticum aestivum), a major global cereal, by whole-genome re-sequencing of 827 Watkins landraces and 208 modern cultivars and in-depth field evaluation spanning a decade. We found that modern cultivars are derived from two of the seven ancestral groups of wheat and maintain very long-range haplotype integrity. The remaining five groups represent untapped genetic sources, providing access to landrace-specific alleles and haplotypes for breeding. Linkage disequilibrium-based haplotypes and association genetics analyses link Watkins genomes to the thousands of identified high-resolution quantitative trait loci and significant marker–trait associations. Using these structured germplasm, genotyping and informatics resources, we revealed many Watkins-unique beneficial haplotypes that can confer superior traits in modern wheat. Furthermore, we assessed the phenotypic effects of 44,338 Watkins-unique haplotypes, introgressed from 143 prioritized quantitative trait loci in the context of modern cultivars, bridging the gap between landrace diversity and current breeding. This study establishes a framework for systematically utilizing genetic diversity in crop improvement to achieve sustainable food security. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_dc3293d79656d45587fd4103bb2af3da |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:10459.1/466820 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| publisher | Nature Research |
| publisherStr | Nature Research |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Harnessing landrace diversity empowers wheat breeding Cheng, Shifeng Feng, Cong Wingen, Luzie U. Cheng, Hong Riche, Andrew B. Jiang, Mei Leverington-Waite, Michelle Huang, Zejian Collier, Sarah Orford, Simon Wang, Xiaoming Awal, Rajani Barker, Gary O’Hara, Tom Lister, Clare Bicego, Breno Alleles Crops, Agricultural Genetic Introgression Genetic Variation Genome, Plant Harnessing genetic diversity in major staple crops through the development of new breeding capabilities is essential to ensure food security1. Here we examined the genetic and phenotypic diversity of the A. E. Watkins landrace collection2 of bread wheat (Triticum aestivum), a major global cereal, by whole-genome re-sequencing of 827 Watkins landraces and 208 modern cultivars and in-depth field evaluation spanning a decade. We found that modern cultivars are derived from two of the seven ancestral groups of wheat and maintain very long-range haplotype integrity. The remaining five groups represent untapped genetic sources, providing access to landrace-specific alleles and haplotypes for breeding. Linkage disequilibrium-based haplotypes and association genetics analyses link Watkins genomes to the thousands of identified high-resolution quantitative trait loci and significant marker–trait associations. Using these structured germplasm, genotyping and informatics resources, we revealed many Watkins-unique beneficial haplotypes that can confer superior traits in modern wheat. Furthermore, we assessed the phenotypic effects of 44,338 Watkins-unique haplotypes, introgressed from 143 prioritized quantitative trait loci in the context of modern cultivars, bridging the gap between landrace diversity and current breeding. This study establishes a framework for systematically utilizing genetic diversity in crop improvement to achieve sustainable food security. The authors thank G. Moore and M. Bevan for providing valuable feedback at multiple stages of the project; colleagues for assistance in Watkins field trial and phenotyping work from five experimental stations across China: Z. Zhu, Q. Wang, Y. Song, Y. Zhu and X. Zhang; the John Innes Centre (JIC) NBI Computing Infrastructure for Science group; the JIC Field Trials and Horticultural Services teams for support in field and glasshouse experiments; T. Florio for figure visualization; and the Rothamsted Research farm team and Analytical Chemistry unit for support in field experiments and analytical mineral analyses. This work was supported by the Program for Guangdong \u201CZhuJiang\u201D Introducing Innovative and Entrepreneurial Teams (2019ZT08N628), the National Natural Science Foundation of China (32022006), the Agricultural Science and Technology Innovation Program (CAAS-ASTIP-2021-AGIS-ZDRW202101), the Shenzhen Science and Technology Program (AGIS-ZDKY202002) to S. Cheng, and the Guangdong Basic and Applied Basic Research Foundation (2020A1515110677) to L.M. The UK work was possible owing to the long-term investment of the UK Biotechnology and Biological Sciences Research Council (BBSRC) in wheat research through Institute Strategic Programme (ISP) grants and longer larger grants: BBSRC LOLA \u2018Enhancing diversity in UK wheat through a public sector prebreeding programme\u2019 (BB/I002545/1); BBSRC ISP \u2018JIC WISP ISP\u2014Wheat Institute Strategic Programme\u2019 (BB/J004596/1); BBSRC ISP \u2018BBSRC Strategic Programme in Designing Future Wheat (DFW)\u2019 (BB/P016855/1); BBSRC ISP \u2018BBSRC Institute Strategic Programme: Delivering Sustainable Wheat (DSW)\u2019 (BB/X011003/1) and for wheat germplasm conservation and global distribution through the Germplasm Resources BBSRC National Capability award (BBS/E/J/000PR8000). S.G. and C.L. also received support from the UK Department for Environment, Food and Rural Affairs (Defra) as part of WGIN phases 3 and 4 (CH0106 and CH0109). This work was also supported by the European Research Council (ERC-2019-COG-866328), the Sustainable Crop Production Research for International Development (SCPRID) programme (BB/J012017/1), the Mexican Consejo Nacional de Ciencia y Tecnolog\u00EDa (CONACYT; 2018-000009-01EXTF-00306), the Science, Technology & Innovation Funding Authority (STDF), Egypt-UK Newton-Mosharafa Institutional Links award, project ID 30718 and EG\u2013US cycle 19\u2013project ID 42687. Nature Research https://doi.org/10.1038/s41586-024-07682-9 https://hdl.handle.net/10459.1/466820 |
| spellingShingle | Harnessing landrace diversity empowers wheat breeding Cheng, Shifeng Alleles Crops, Agricultural Genetic Introgression Genetic Variation Genome, Plant |
| status_str | publishedVersion |
| title | Harnessing landrace diversity empowers wheat breeding |
| title_full | Harnessing landrace diversity empowers wheat breeding |
| title_fullStr | Harnessing landrace diversity empowers wheat breeding |
| title_full_unstemmed | Harnessing landrace diversity empowers wheat breeding |
| title_short | Harnessing landrace diversity empowers wheat breeding |
| title_sort | Harnessing landrace diversity empowers wheat breeding |
| topic | Alleles Crops, Agricultural Genetic Introgression Genetic Variation Genome, Plant |
| topic_facet | Alleles Crops, Agricultural Genetic Introgression Genetic Variation Genome, Plant |
| url | https://doi.org/10.1038/s41586-024-07682-9 https://hdl.handle.net/10459.1/466820 |