Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9
Chromosomal fusions represent one of the most common types of chromosomal rearrangements found in nature. Yet, their role in shaping the genomic landscape of recombination and hence genome evolution remains largely unexplored. Here, we take advantage of wild mice populations with chromosomal fusions...
| Authors: | ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Publication date: | 2024 |
| Country: | España |
| Institution: | Universitat Autònoma de Barcelona |
| Repository: | Dipòsit Digital de Documents de la UAB |
| Language: | English |
| OAI Identifier: | oai:ddd.uab.cat:300321 |
| Online Access: | https://ddd.uab.cat/record/300321 https://dx.doi.org/urn:doi:10.1093/molbev/msae063 |
| Access Level: | Open access |
| Keyword: | Robertsonian fusions Recombination Crossovers Prdm9 Genomic divergence Mus musculus domesticus |
| _version_ | 1878740812109447168 |
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| author | Marin Garcia, Cristina|||0000-0002-5008-1078 |
| author2 | Álvarez-González, Lucía|||0000-0001-8154-8614 Marin Gual, Laia|||0000-0003-1480-0976 Casillas Viladerrams, Sònia|||0000-0001-8191-0062 Picón, Judith Yam, Keren Garcias-Ramis, Maria Magdalena|||0000-0001-9725-5066 Vara González, Covadonga|||0000-0002-8264-9262 Ventura Queija, Jacinto|||0000-0001-7527-1532 Ruiz Herrera Moreno, Aurora|||0000-0003-3868-6151 |
| author2_role | author author author author author author author author author |
| author_browse | Casillas Viladerrams, Sònia|||0000-0001-8191-0062 Garcias-Ramis, Maria Magdalena|||0000-0001-9725-5066 Marin Garcia, Cristina|||0000-0002-5008-1078 Marin Gual, Laia|||0000-0003-1480-0976 Picón, Judith Ruiz Herrera Moreno, Aurora|||0000-0003-3868-6151 Vara González, Covadonga|||0000-0002-8264-9262 Ventura Queija, Jacinto|||0000-0001-7527-1532 Yam, Keren Álvarez-González, Lucía|||0000-0001-8154-8614 |
| author_facet | Marin Garcia, Cristina|||0000-0002-5008-1078 Álvarez-González, Lucía|||0000-0001-8154-8614 Marin Gual, Laia|||0000-0003-1480-0976 Casillas Viladerrams, Sònia|||0000-0001-8191-0062 Picón, Judith Yam, Keren Garcias-Ramis, Maria Magdalena|||0000-0001-9725-5066 Vara González, Covadonga|||0000-0002-8264-9262 Ventura Queija, Jacinto|||0000-0001-7527-1532 Ruiz Herrera Moreno, Aurora|||0000-0003-3868-6151 |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | Chromosomal fusions represent one of the most common types of chromosomal rearrangements found in nature. Yet, their role in shaping the genomic landscape of recombination and hence genome evolution remains largely unexplored. Here, we take advantage of wild mice populations with chromosomal fusions to evaluate the effect of this type of structural variant on genomic landscapes of recombination and divergence. To this aim, we combined cytological analysis of meiotic crossovers in primary spermatocytes with inferred analysis of recombination rates based on linkage disequilibrium using single nucleotide polymorphisms. Our results suggest the presence of a combined effect of Robertsonian fusions and Prdm9 allelic background, a gene involved in the formation of meiotic double strand breaks and postzygotic reproductive isolation, in reshaping genomic landscapes of recombination. We detected a chromosomal redistribution of meiotic recombination toward telomeric regions in metacentric chromosomes in mice with Robertsonian fusions when compared to nonfused mice. This repatterning was accompanied by increased levels of crossover interference and reduced levels of estimated recombination rates between populations, together with high levels of genomic divergence. Interestingly, we detected that Prdm9 allelic background was a major determinant of recombination rates at the population level, whereas Robertsonian fusions showed limited effects, restricted to centromeric regions of fused chromosomes. Altogether, our results provide new insights into the effect of Robertsonian fusions and Prdm9 background on meiotic recombination. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_d9cf5b26dfd681e5eded8d1cc7b3eb6b |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:300321 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9 Marin Garcia, Cristina|||0000-0002-5008-1078 Álvarez-González, Lucía|||0000-0001-8154-8614 Marin Gual, Laia|||0000-0003-1480-0976 Casillas Viladerrams, Sònia|||0000-0001-8191-0062 Picón, Judith Yam, Keren Garcias-Ramis, Maria Magdalena|||0000-0001-9725-5066 Vara González, Covadonga|||0000-0002-8264-9262 Ventura Queija, Jacinto|||0000-0001-7527-1532 Ruiz Herrera Moreno, Aurora|||0000-0003-3868-6151 Robertsonian fusions Recombination Crossovers Prdm9 Genomic divergence Mus musculus domesticus Chromosomal fusions represent one of the most common types of chromosomal rearrangements found in nature. Yet, their role in shaping the genomic landscape of recombination and hence genome evolution remains largely unexplored. Here, we take advantage of wild mice populations with chromosomal fusions to evaluate the effect of this type of structural variant on genomic landscapes of recombination and divergence. To this aim, we combined cytological analysis of meiotic crossovers in primary spermatocytes with inferred analysis of recombination rates based on linkage disequilibrium using single nucleotide polymorphisms. Our results suggest the presence of a combined effect of Robertsonian fusions and Prdm9 allelic background, a gene involved in the formation of meiotic double strand breaks and postzygotic reproductive isolation, in reshaping genomic landscapes of recombination. We detected a chromosomal redistribution of meiotic recombination toward telomeric regions in metacentric chromosomes in mice with Robertsonian fusions when compared to nonfused mice. This repatterning was accompanied by increased levels of crossover interference and reduced levels of estimated recombination rates between populations, together with high levels of genomic divergence. Interestingly, we detected that Prdm9 allelic background was a major determinant of recombination rates at the population level, whereas Robertsonian fusions showed limited effects, restricted to centromeric regions of fused chromosomes. Altogether, our results provide new insights into the effect of Robertsonian fusions and Prdm9 background on meiotic recombination. https://ddd.uab.cat/record/300321 https://dx.doi.org/urn:doi:10.1093/molbev/msae063 |
| spellingShingle | Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9 Marin Garcia, Cristina|||0000-0002-5008-1078 Robertsonian fusions Recombination Crossovers Prdm9 Genomic divergence Mus musculus domesticus |
| title | Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9 |
| title_full | Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9 |
| title_fullStr | Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9 |
| title_full_unstemmed | Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9 |
| title_short | Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9 |
| title_sort | Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9 |
| topic | Robertsonian fusions Recombination Crossovers Prdm9 Genomic divergence Mus musculus domesticus |
| topic_facet | Robertsonian fusions Recombination Crossovers Prdm9 Genomic divergence Mus musculus domesticus |
| url | https://ddd.uab.cat/record/300321 https://dx.doi.org/urn:doi:10.1093/molbev/msae063 |