Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability
White adipose tissue (WAT) produces lactate in significant amount from circulating glucose, especially in obesity;Under normoxia, 3T3L1 cells secrete large quantities of lactate to the medium, again at the expense of glucose and proportionally to its levels. Most of the glucose was converted to lact...
| Autores: | ; ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2014 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/52928 |
| Acceso en línea: | https://hdl.handle.net/2445/52928 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Teixit adipós Glucosa Cultius cel·lulars humans Adipose tissues Glucose Human cell culture |
| _version_ | 1878740755312279552 |
|---|---|
| author | Sabater Martínez, David |
| author2 | Arriarán, Sofía Romero Romero, María del Mar Agnelli, Silvia Fernández López, José Antonio Remesar Betlloch, Xavier Alemany, Marià, 1946- |
| author2_role | author author author author author author |
| author_browse | Agnelli, Silvia Alemany, Marià, 1946- Arriarán, Sofía Fernández López, José Antonio Remesar Betlloch, Xavier Romero Romero, María del Mar Sabater Martínez, David |
| author_facet | Sabater Martínez, David Arriarán, Sofía Romero Romero, María del Mar Agnelli, Silvia Fernández López, José Antonio Remesar Betlloch, Xavier Alemany, Marià, 1946- |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | White adipose tissue (WAT) produces lactate in significant amount from circulating glucose, especially in obesity;Under normoxia, 3T3L1 cells secrete large quantities of lactate to the medium, again at the expense of glucose and proportionally to its levels. Most of the glucose was converted to lactate with only part of it being used to synthesize fat. Cultured adipocytes were largely anaerobic, but this was not a Warburg-like process. It is speculated that the massive production of lactate, is a process of defense of the adipocyte, used to dispose of excess glucose. This way, the adipocyte exports glucose carbon (and reduces the problem of excess substrate availability) to the liver, but the process may be also a mechanism of short-term control of hyperglycemia. The in vivo data obtained from adipose tissue of male rats agree with this interpretation. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_d8d2fd4ee511142cf65a37f4ac75a0ef |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/52928 |
| publishDate | 2014 |
| publishDateSort | 2014 |
| publisher | Nature Publishing Group |
| publisherStr | Nature Publishing Group |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability Sabater Martínez, David Arriarán, Sofía Romero Romero, María del Mar Agnelli, Silvia Fernández López, José Antonio Remesar Betlloch, Xavier Alemany, Marià, 1946- Teixit adipós Glucosa Cultius cel·lulars humans Adipose tissues Glucose Human cell culture White adipose tissue (WAT) produces lactate in significant amount from circulating glucose, especially in obesity;Under normoxia, 3T3L1 cells secrete large quantities of lactate to the medium, again at the expense of glucose and proportionally to its levels. Most of the glucose was converted to lactate with only part of it being used to synthesize fat. Cultured adipocytes were largely anaerobic, but this was not a Warburg-like process. It is speculated that the massive production of lactate, is a process of defense of the adipocyte, used to dispose of excess glucose. This way, the adipocyte exports glucose carbon (and reduces the problem of excess substrate availability) to the liver, but the process may be also a mechanism of short-term control of hyperglycemia. The in vivo data obtained from adipose tissue of male rats agree with this interpretation. Nature Publishing Group https://hdl.handle.net/2445/52928 |
| spellingShingle | Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability Sabater Martínez, David Teixit adipós Glucosa Cultius cel·lulars humans Adipose tissues Glucose Human cell culture |
| status_str | publishedVersion |
| title | Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability |
| title_full | Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability |
| title_fullStr | Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability |
| title_full_unstemmed | Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability |
| title_short | Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability |
| title_sort | Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability |
| topic | Teixit adipós Glucosa Cultius cel·lulars humans Adipose tissues Glucose Human cell culture |
| topic_facet | Teixit adipós Glucosa Cultius cel·lulars humans Adipose tissues Glucose Human cell culture |
| url | https://hdl.handle.net/2445/52928 |