Quantitative informant- and self-reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4

Introduction: Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals. Methods: A total o...

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Autores: Sánchez Benavides, Gonzalo; Salvadó, Gemma; Arenaza Urquijo, Eider M.; Grau Rivera, Oriol; Suárez Calvet, Marc; Milà Alomà, Marta; González de Echávarri, José M.; Minguillón, Carolina; Crous Bou, Marta; Niñerola Baizán, Aida; Perissinotti, Andrés; Gispert, Juan Domingo; Molinuevo, José Luis; ALFA Study
Tipo de documento: Artículo
Estado:Published version
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/185358
Acceso en línea:https://hdl.handle.net/2445/185358
Nivel de acceso:Acceso abierto
Palabra clave:Malaltia d'Alzheimer
Amiloïdosi
Trastorns de la cognició
Símptomes
Diagnòstic
Alzheimer's disease
Amyloidosis
Cognition disorders
Symptoms
Diagnosis
Sumario:Introduction: Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals. Methods: A total of 261 participants from the ALFA+ study underwent [18F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD-Q) concurrently, and 3 years before scan. We used logistic regressions to evaluate the ability of SCD-Q scores (self and informant) to predict Aβ PET visual read, and repeated analysis of variance to assess whether changes in SCD-Q scores relate to Aβ status. Results: Self-perception of decline in memory (odds ratio [OR] = 1.2), and informant perception of executive decline (OR = 1.6), increased the probability of a positive scan. Informant reports 3 years before scanning predicted Aβ PET outcome. Longitudinal increase of self-reported executive decline was predictive of Aβ in women (P = .003). Discussion: Subjective reports of cognitive decline are useful to predict Aβ and may improve recruitment strategies.

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