Safety Profile and Tolerability of Topical Phosphodiesterase 4 Inhibitors for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis
Evaluate the safety profile and tolerability of topical phosphodiesterase 4 (PDE4) inhibitors versus vehicle as treatment for atopic dermatitis in published studies.A search was performed in Medline/PubMed, Web of Science, and Cochrane Library databases on September 27, 2021, by 1 evaluator, without...
| Autores: | ; ; ; |
|---|---|
| Tipo de documento: | Artigo |
| Estado: | Published version |
| Data de publicação: | 2022 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositório: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/201455 |
| Acesso em linha: | https://hdl.handle.net/2445/201455 |
| Nível de acesso: | Acesso aberto |
| Palavra-chave: | Dermatitis atòpica Inhibidors de fosfodiesterases Atopic dermatitis Phosphodiesterase Inhibitors |
| _version_ | 1878740691154108416 |
|---|---|
| author | Martín Santiago, Ana |
| author2 | Puig i Sardà, Susana Arumí, Daniel Rebollo Laserna, Francisco José |
| author2_role | author author author |
| author_browse | Arumí, Daniel Martín Santiago, Ana Puig i Sardà, Susana Rebollo Laserna, Francisco José |
| author_facet | Martín Santiago, Ana Puig i Sardà, Susana Arumí, Daniel Rebollo Laserna, Francisco José |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Evaluate the safety profile and tolerability of topical phosphodiesterase 4 (PDE4) inhibitors versus vehicle as treatment for atopic dermatitis in published studies.A search was performed in Medline/PubMed, Web of Science, and Cochrane Library databases on September 27, 2021, by 1 evaluator, without restrictions on publication dates or languages. Terms such as atopic dermatitis, phosphodiesterase 4 inhibitors, calcineurin inhibitors, and randomized controlled trials were included. The database searches were carried out by 1 evaluator. The titles and abstracts were reviewed for the identification and evaluation of potentially eligible studies. Study selection was made by two reviewers, so there was no intra-examiner statistic at the study selection step. The full-text articles were reviewed to determine whether or not they would be included in the systematic review. Global analyses, which included studies with both unclear and low risk of bias and subanalyses of studies with a low risk of bias were performed.Out of 237 identified articles, 14 clinical trials were included in the meta-analysis. In global analyses of studies with low and unclear risk of bias, topical treatment with PDE4 inhibitors did not differ from vehicle treatment in global treatment emergent adverse events (relative risk?=?0.99; 95% CI, 0.87-1.14; P?=?0.94) or in serious emergent adverse events appearance (relative risk?=?0.92; 95% CI, 0.39-2.20; P?=?0.86). In subanalyses of studies with a low risk of bias, a reduced rate of atopic dermatitis exacerbation was observed in PDE4 inhibitors compared with the vehicle (relative risk?=?0.62; 95% CI, 0.39-0.98; P?=?0.04) and risk of pain at the application site was confirmed (relative risk?=?2.59; 95% CI, 1.27-5.28; P?=?0.01).PDE4 inhibitors did not show differences from vehicle treatment in treatment emergent adverse events or serious emergent adverse events incidence. In studies with low risk of bias, PDE4 inhibitors had a statistically significant risk of producing pain and reduced occurrence of atopic dermatitis exacerbation.© 2022 The Author(s). |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_d7a1c33fdfb8cfd4b4e7cfd65a05c6c2 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/201455 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher | Elsevier BV |
| publisherStr | Elsevier BV |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Safety Profile and Tolerability of Topical Phosphodiesterase 4 Inhibitors for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis Martín Santiago, Ana Puig i Sardà, Susana Arumí, Daniel Rebollo Laserna, Francisco José Dermatitis atòpica Inhibidors de fosfodiesterases Atopic dermatitis Phosphodiesterase Inhibitors Evaluate the safety profile and tolerability of topical phosphodiesterase 4 (PDE4) inhibitors versus vehicle as treatment for atopic dermatitis in published studies.A search was performed in Medline/PubMed, Web of Science, and Cochrane Library databases on September 27, 2021, by 1 evaluator, without restrictions on publication dates or languages. Terms such as atopic dermatitis, phosphodiesterase 4 inhibitors, calcineurin inhibitors, and randomized controlled trials were included. The database searches were carried out by 1 evaluator. The titles and abstracts were reviewed for the identification and evaluation of potentially eligible studies. Study selection was made by two reviewers, so there was no intra-examiner statistic at the study selection step. The full-text articles were reviewed to determine whether or not they would be included in the systematic review. Global analyses, which included studies with both unclear and low risk of bias and subanalyses of studies with a low risk of bias were performed.Out of 237 identified articles, 14 clinical trials were included in the meta-analysis. In global analyses of studies with low and unclear risk of bias, topical treatment with PDE4 inhibitors did not differ from vehicle treatment in global treatment emergent adverse events (relative risk?=?0.99; 95% CI, 0.87-1.14; P?=?0.94) or in serious emergent adverse events appearance (relative risk?=?0.92; 95% CI, 0.39-2.20; P?=?0.86). In subanalyses of studies with a low risk of bias, a reduced rate of atopic dermatitis exacerbation was observed in PDE4 inhibitors compared with the vehicle (relative risk?=?0.62; 95% CI, 0.39-0.98; P?=?0.04) and risk of pain at the application site was confirmed (relative risk?=?2.59; 95% CI, 1.27-5.28; P?=?0.01).PDE4 inhibitors did not show differences from vehicle treatment in treatment emergent adverse events or serious emergent adverse events incidence. In studies with low risk of bias, PDE4 inhibitors had a statistically significant risk of producing pain and reduced occurrence of atopic dermatitis exacerbation.© 2022 The Author(s). Elsevier BV https://hdl.handle.net/2445/201455 |
| spellingShingle | Safety Profile and Tolerability of Topical Phosphodiesterase 4 Inhibitors for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis Martín Santiago, Ana Dermatitis atòpica Inhibidors de fosfodiesterases Atopic dermatitis Phosphodiesterase Inhibitors |
| status_str | publishedVersion |
| title | Safety Profile and Tolerability of Topical Phosphodiesterase 4 Inhibitors for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis |
| title_full | Safety Profile and Tolerability of Topical Phosphodiesterase 4 Inhibitors for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis |
| title_fullStr | Safety Profile and Tolerability of Topical Phosphodiesterase 4 Inhibitors for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Safety Profile and Tolerability of Topical Phosphodiesterase 4 Inhibitors for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis |
| title_short | Safety Profile and Tolerability of Topical Phosphodiesterase 4 Inhibitors for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis |
| title_sort | Safety Profile and Tolerability of Topical Phosphodiesterase 4 Inhibitors for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis |
| topic | Dermatitis atòpica Inhibidors de fosfodiesterases Atopic dermatitis Phosphodiesterase Inhibitors |
| topic_facet | Dermatitis atòpica Inhibidors de fosfodiesterases Atopic dermatitis Phosphodiesterase Inhibitors |
| url | https://hdl.handle.net/2445/201455 |