Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction

BACKGROUND The potential benefit of dual antiplatelet therapy beyond 1 year after a myocardial infarction has not been established. We investigated the efficacy and safety of ticagrelor, a P2Y(12) receptor antagonist with established efficacy after an acute coronary syndrome, in this context. METHOD...

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Autores: Bonaca, MP; Bhatt, DL; Cohen, M; Steg, PG; Storey, RF; Jensen, EC; Magnani, G; Bansilal, S; Fish, MP; Im, K; Bengtsson, O; Ophuis, TO; Budaj, A; Theroux, P; Ruda, M; Hamm, C; Goto, S; Spinar, J; Nicolau, JC; Kiss, RG; Murphy, SA; Wiviott, SD; Held, P; Braunwald, E; Sabatine, MS; Morin, S; Dantzer, E; Acquilano, D; McGuire, RL; Gannon, JB; Gershman, E; Ahlbom, AM; Boberg, B; Abola, MT; Ardissino, D; Aylward, P; Corbalan, R; Dalby, A; Diaz, R; Hu, DY; Isaza, D; Kamensky, G; Kiss, R; Kontny, F; Lopez-Sendon, J; Medina, F; Montalescot, G; Nicolau, J; Paolasso, E; Parkhomenko, A; Van De Werf, F; Anderson, JL; White, HD; Verheugt, FWA; Pedersen, TR; DeMets, DL; Lowe, C; Arevalo, C; Awtry, E; Berger, C; Croce, K; Desai, A; Gelfand, E; Ho, C; Leeman, D; Link, M; Norden, A; Pande, A; Rost, N; Ruberg, F; Silverman, S; Singhal, A; Vita, J; Alvarisqueta, A; De Gennaro, N; Berli, M; Roude, AE; Di Gennaro, JA; Albisu, JF; Caccavo, A; Torres, M; Cuadrado, J; Bordoni, P; Cuello, J; Aviles, A; Glenny, A; Recoaro, R; Fernandez, R; Strada, BN; Fuentealba, V; Gallo, C; Duran, RG; Garcia, C; Hominal, M; Castoldi, M; Jure, H; Pacora, FF; Lorenzatti, A; Martinez, JM; Macin, S; Cocco, N; MacKinnon, I; Bagnato, MB; Marino, J; Cusimano, S; Arias, V; Focaccia, M; Muntaner, J; Mansilla, V; Poy, C; Prado, A; Paterlini, G; Montana, O; Camino, A; Sala, J; Luciani, C; Vico, M; Morell, Y; Dumont, C; Vottero, E; Zangroniz, P; Lescano, A; Morara, P; Marquez, LL; Patron, FR; Labarta, GB; Sivila, CD; Quiroga, AR; Maffei, L; Sassone, S; Rolandi, F; Vesentini, N; Carnero, G; Del Verme, S; Hershson, A; Figal, JC; Viso, ME; Hii, C; Smith, K; Singh, B; Acampo, M; Rogers, J; ODonoghue, M; Amerena, J; Long, A; Dart, A; Kay, S; Worthley, M; Nimmo, J; Lehman, R; Morrison, H; Dick, R; Savage, C; van Gaal, W; Park, M; Blombery, P; McCarthy, C; Oqueli, E; Hill, D; Sader, M; Vrachas, D; Purnell, P; Vibert, J; Collins, N; Gordon, A; Arstall, M; Rose, J; Aroney, C; Cleave, P; Fitzpatrick, M; Mackenzie, M; Garrahy, P; Hall, C; Nelson, G; Reid, E; Lee, A; Gibbs, J; Thompson, P; Crittenden, J; Hammett, C; Hindom, L; Antonis, P; Manzoney, A; Cross, D; Pollard, C; Brieger, D; Wu, J; Whelan, A; Tulloch, G; Taylor, A; Smith, B; Horowitz, J; Black, M; Boland, J; Malmendier, D; Celen, H; Wendelen, E; Claeys, M; Pieter, M; Cools, F; Simons, N; De Maeseneire, S; De Wolf, L; Brike, C; Dubois, P; Bolado, ACY; Foading-Deffo, B; Tahon, S; Friart, A; Arend, C; Gevaert, S; Verdegem, P; Marechal, P; Gits, F; Pierard, L; Celentano, C; Pirenne, B; Bouvy, C; Renkin, J; Huyberechts, D; Sinnaeve, P; De Velder, L; Stammen, F; Casier, T; Striekwold, H; Van den Broeck, D; Thoeng, J; Goris, R; Timmermans, P; Collard, SJ; Van De Borne, P; De Clippel, M; Wollaert, B; Jacobs, C; Vankelecom, B; Daelemans, Y; Vervoort, G; Drieghe, S; Vranckx, P; Janssen, A; Vrolix, M; Simenon, I; Wijns, W; Delacroix, H; Denie, D; Schoors, D; Lemoine, I; Cornelis, K; Willems, AM; Schroder, E; Domange, J; Greque, G; Machado, H; Armaganijan, D; Del Monaco, MI; da Silva, D; Nakazone, R; Dutra, O; Vaz, R; Daher, R; Rodrigues, D; Guimaraes, A; Teixeira, A; Saraiva, J; Leaes, P; Blacher, M; Maia, L; Nakazone, MA; Manenti, E; Ruschel, K; Marin-Neto, J; Pavao, R; Preto, R; Junior, AA; Oliveira, G; Rassi, S; Sampaio, D; Rossi, PR; dos Santos, L; de Souza, J; Lino, E; Filho, PP; Zucchetti, C; Gomes, M; de Paiva, A; Sousa, AC; Almeida, A; Botelho, R; da Silva, R; Giraldez, R; Franken, M; Faludi, A; Bertolami, M; Hernandes, M; Lucas, N; Carvalho, A; Bertolami, A; Precoma, D; Geralde, L; Pereira, A; Cesar, L; Mioto, B; Marino, R; Rabelo, W; dos Santos, F; Vidotti, M; Mangione, J; Mauro, M; Kormann, A; Ultramari, F; Zimmermann, S; Michalaros, Y; Fonseca, M; Sampaio, C; Eliaschewitz, F; Barbosa, E; Drews, C; de Lorenzo, A; Barros, C; Cancado, G; Neuesnchwander, F; Zimmermann, E; Chompalova, B; Denchev, S; Gocheva, N; Mihov, A; Mincheva, V; Gelev, V; Tisheva, S; Todorov, G; Goudev, A; Parvanova, Z; Todorova, M; Mitkova, M; Smilov, L; Yakovova, S; Milanova, K; Aleksov, N; Mollov, M; Shishmanova, D; Hristova, K; Uzunangelov, Y; Peltegov, V; Karamitev, G; Benov, H; Vasileva, D; Parishev, G; Milcheva, N; Avramov, D; Miteva, B; Stoyanovski, V; Pencheva, G; Nikolova, L; Stancheva, N; Nyagina, M; Markov, D; Spirova, D; Peneva, Y; Peshkov, O; Mitkova, L; Mandzhukova, S; Rangelova, V; Ivanov, K; Krusheva, B; Raycheva, V; Gergova, V; Goranov, K; Stoykov, A; Staleva, M; Rashkova, V; Postadzhian, A; Krancheva, V; Lulova, E; Delchev, G; Cantor, W; Constance, C; Gosselin, G; Marr, D; Pandey, A; Pesant, Y; Pouliot, J; Gladstone, P; McPherson, T; Rupka, D; Saw, J; St-Amour, E; Syan, G; Syan, R; Rosenbloom, A; Vizel, S; Della Siega, A; Halperin, F; Nigro, F; Chehayeb, R; Fell, D; Labonte, R; Nawaz, S; Gupta, M; Ma, P; Glanz, A; Kouz, S; Bhargava, R; Dion, D; Dupuis, R; Grondin, F; Wong, B; Sabbah, E; Hui, W; Belisle, P; Tymchak, W; Montigny, M; Lonn, E; Bose, S; Kincade, D; Gallo, R; Lamy, A; Bell, A; Lemay, M; Bata, I; Kostuk, W; Cheung, S; Petrella, R; Lubelsky, B; Berlingieri, J; Fortin, C; DeYoung, J; Babapulle, M; Landry, D; Gupta, A; Bertrand, O; Jadin, M; Robbins, K; Gauthier, MF; Masson, C; Reyes, V; O'Blenis, G; Clarus, S; Sardin, V; Marquette, S; Bozek, B; Spurrell, D; Thiessen, S; Fox, R; Tremblay, I; Singh, J; Samms, S; Ross, B; Solomon, P; Nelson, S; Roberts, P; Forsyth, C; Lepage, C; McPherson, C; Dewar, C; Dela Cruz, C; Louch, D; Vilag, C; Roy, M; Stata, C; Morissette, A; Ouimet, F; Bilodeau, N; Chausse, I; Kvill, L; Chartrand, MJ; Harris, L; Bolduc, H; Magi, A; Jule, P; Valley, S; Morrissette, J; Power, P; Kailey, P; Thomas, A; Wright, D; Carr, S; Cleveland, T; Dihel, C; Coldwell, J; Schellenberg, S; Viau, C; Watt, M; Corke, R; Shea-Landry, G; Gandhi, A; Tishler, S; Prieto, JC; Noriega, V; Cobos, L; Obreque, C; Potthof, S; Zapata, J; Lucero, F; Luque, M; Pincetti, C; Torres, G; Yanez, M; Vasquez, C; Manriquez, L; Espinoza, MJ; Yovaniniz, P; Grandon, M; Castro, P; Llevaneras, S; Lanas, F; Hidalgo, J; Arriagada, G; Villan, C; Florenzano, F; Chacon, MV; Rodriguez, M; Barreda, B; Raffo, C; Reyes, T; Hu, D; Liu, W; Tan, N; Feng, Y; Dong, Y; Yang, D; Liao, Y; Wei, F; Wei, M; Yan, M; Yan, X; Wang, S; Li, Y; Yuan, Z; Xiong, Y; Zhu, J; Li, S; Ma, G; Chen, L; Li, Z; Liu, Y; Xiong, W; Pang, W; Chen, Y; Lu, G; Chen, Z; Zhao, S; Zhou, H; Huang, J; Gang, Y; Chai, Y; Yang, X; Zhang, Z; Mu, Z; Hernandez, E; Mora, C; Maria, E; Catalan, Y; Reynales, H; Huertas, D; Molina, D; Rendon, N; Sanchez, G; Tellez, R; Botero, R; Salazar, P; Vesga, B; Delgado, P; Herrera, M; Perez, D; Jaramillo, N; Toloza, R; Orozco, A; Bustamante, Y; Jaramillo, C; Garces, G; Saaibi, J; Castillo, J; Arana, C; Gonzalez, M; Urina, M; Ramirez, N; Manzur, F; Rosales, D; Quintero, A; Gonzalez, E; Accini, J; Reyes, M; Elbl, L; Malecha, J; Stanek, L; Jerabek, O; Lubanda, H; Kos, P; Zidkova, E; Vlckova, D; Naplava, R; Ludka, O; Ludkova, A; Soucek, M; Kuchar, J; Poloczek, M; Wasserburger, B; Panovsky, R; Linhart, A; Rihacek, I; Macha, J; Grunfeldova, H; Spinarova, L; Zanova, M; Bren, J; Zarembova, J; Cermak, O; Sembera, Z; Svobodova, I; Monhart, Z; Pleva, L; Sipula, J; Polasek, R; Kolmas, P; Dedek, V; Janota, T; Stipal, R; Kucera, D; Bednarova, J; Broulova, P; Lukac, M; Hanak, P; Reichert, P; Bouchal, P; Turkova, N; Krocova, E; Petrova, I; Matyasek, I; Brychta, T; Machova, V; Marusincova, I; Sperlingova, B; Macquin-Mavier, T; Khalife, K; Galley, D; Elhadad, S; Decoulx, E; Cottin, Y; Coisne, D; Bonnet, JL; Ferrari, E; Range, G; Cayla, G; Goralski, M; Furber, A; Elbaz, M; Aboyans, V; Poulard, JE; Zemour, G; Labeque, JN; Hirsch, JL; Vaquette, B; Livarek, B; Igigabel, P; Lafitte, S; Oudghiri, M; Bertin, B; Beitar, T; Merkling, D; Beltra, C; Maubert, A; El Jarroudi, M; Bichat, F; Berger, N; Fiacchetti, C; Douillet, M; Laure, C; Leperchois-Jacquey, C; Miran, S; Cornet, C; Rosolin, N; Pradel, V; Leparree, S; Doux, N; Mais, C; Sevilla, J; Laurencon, V; Georges, J; Gilard, V; Duprat, C; Giannitsis, E; Schenkenberger, I; Appel, KF; Toursarkissian, N; Bott, J; Nischik, R; Schmidt, E; Jung, T; Steiner, S; Khariouzov, A; Heuer, H; Kadel, C; Hanefeld, M; Weil, J; Koenig, W; Horacek, T; Muenzel, T; Brachmann, J; Weber, D; Wittlich, N; Stellbrink, C; Dungen, HD; Leschke, M; Zeymer, U; Dorsel, T; Voehringer, HF; Dissmann, M; Vom Dahl, J; Derwahl, KM; Trenk, D; Frey, N; Schroeder, T; Foerster, A; Bartels, R; Kisselbach, C; Deigentasch, H; Dreykluft, K; Becker, P; Scheuren, A; Erdas, M; Wipper, J; Schmidt, A; Henzler, A; Winter, K; Fischer, S; Kopf, S; Laschewski, B; Rahn, G; Schrapel, C; Miodek, M; Hildenbrand, S; Fink, P; Gebel, G; Goebel, U; Siepmann, C; Drexler, A; Maiwald, A; Blaich, B; Baumann, S; Iselt, M; Gebhardt, S; Kazcmarek, N; Krug-Hoeren, B; Traubler, B; Nicula, D; Reichenbach, D; Langer, C; Kiroglu, K; Riedel, S; Schulte, M; Borst, M; Katona, A; Vertes, A; Merkely, B; Ungi, I; Kiraly, C; Zolyomi, S; Horvath, I; Lupkovics, G; Edes, I; Simon, E; Czuriga, I; Laszlo, Z; Kancz, S; Takacs, J; Papp, A; Czigany, A; Muller, G; Tas, AS; Polgar, P; Jilling, MJ; Bartal, G; Kerkovits, A; Bodi, M; Benczur, B; Valco, J; Erdei, F; Sebo, J; Korda, A; Turi, T; Becker, D; Kalapos, A; Bosko, M; Pap, G; Magyari, B; Basa, A; Jenei, C; Bakai, J; Unterberger, K; Vas, K; Fulop, G; Nagy, M; Takacs, A; Mate, Z; Szilagyi, A; Nagy, K; Svab, M; Kis, E; Horthy, R; Kantor, F; Sperr, E; Bajcsi, E; Bujdoso, A; Martina, P; Fiscella, A; Marenzi, G; Tamburino, C; Terrosu, P; Presbitero, P; Cuccia, C; Bovenzi, F; Berti, S; Colivicchi, F; Paloscia, L; Scherillo, M; Tartaglione, S; Della Rovere, F; De Cesare, N; Manari, A; Astarita, C; Oltrona, L; Marzilli, M; Caldarola, P; Merlini, P; Celentano, A; Di Sciascio, G; Pajes, G; Silvestri, O; Delfino, R; Bassani, F; Cavallini, C; Fattore, L; Di Lorenzo, L; Notarangelo, F; Stefanin, C; Giacoppo, M; Rubino, M; Dammino, L; Chessa, P; Di Pizzo, A; Musmeci, G; Mazzoni, A; Tyack, K; Aiello, A; Mascellanti, M; Formigli, D; Guglielmino, G; Bernabo, P; Bocciarelli, M; De Iaco, G; Russo, G; Rizzotti, D; Orsini, E; Saponetti, LS; Babbolin, M; De Divitiis, M; Patti, G; Monti, F; Silvestri, N; Valbusa, A; Lazzarotti, M; Puccetti, L; Grikstaite, E; Patrizi, G; Bosco, B; Marchegiano, R; Takenaka, T; Ono, M; Suzuki, M; Hasegawa, K; Domae, H; Fukui, K; Iseki, H; Aoyama, T; Suzuki, C; Sakai, R; Hashimoto, T; Inoko, M; Sasaki, T; Kataoka, T; Okutsu, M; Yasaka, Y; Miyamoto, T; Tomobuchi, Y; Tamura, R; Hosokawa, S; Komura, Y; Takahashi, N; Mima, T; Sadamatsu, K; Fujimoto, K; Matsumura, T; Koide, S; Himi, T; Hashimoto, Y; Yamasaki, M; Okubo, M; Takase, H; Morii, I; Utsu, N; Higashino, Y; Shigematsu, S; Nakagawa, T; Ota, T; Takahashi, W; Kakishita, M; Hayashi, Y; Momiyama, Y; Baden, M; Saeki, T; Hiroi, S; Wada, A; Nakata, A; Nishi, Y; Hirasawa, S; Shibata, Y; Fukuzawa, S; Machida, M; Takama, N; Teranishi, J; Sakuma, K; Abe, Y; Suzuki, A; Yamazaki, A; Nakachi, T; Nagayama, H; Fujino, S; Tsurukai, A; Nojima, S; Ishiguchi, Y; Hada, K; Nakatani, K; Yamamoto, K; Matsuo, A; Yamaguchi, E; Ito, S; Matsuda, M; Onishi, M; Kawanishi, Y; Ohashi, Y; Ochi, K; Miyamoto, S; Ichishita, Y; Iwamoto, H; Sagara, Y; Komori, M; Matsumura, A; Nakashima, R; Kondo, M; Suzuki, K; Kodama, S; Kotajima, H; Fujimoto, N; Honda, K; Iwamoto, M; Okada, S; Ichinose, K; Takinami, N; Takagi, E; Nakano, A; Tomari, H; Yokoyama, T; Matsui, Y; Nishimura, N; Asano, T; Mochiduki, A; Yamashita, S; Okino, S; Hirabayashi, K; Funada, R; Wardeh, AJ; Dille, C; De Melker, EC; van der Spoel, A; Willems, FF; Maassen, E; Westendorp, ICD; Zweers, D; Dunselman, PHJM; Blom, L; Ronner, E; Wissenburg, A; van der Sluis, A; Badings, EA; den Hartog, FR; Singerling, M; Aksoy, I; Heil, A; Tjeerdsma, G; van Daalen, C; Lenderink, T; Lardenois, R; Prins, FJ; Rutten, R; Plomp, J; Veldmeijer, S; De Vries, RJM; Krikken, J; Ophuis, TAJMO; Buvelot, S; Bos, RJ; Tan-Urgert, B; Werner, HA; Wittekoek, M; van Daele, MERM; Bouwens, M; Oomen, A; Meijlis, P; Verheul, JA; Uiterwaal, H; Knufman, N; de Lange, H; Bartels, GL; Hendriks-Van Woerden, M; van Bemmel, B; Beyering, M; Zwart, PAG; Teng, Y; van der Zwaan, C; Havenaar, J; Hermans, WRM; de Graauw, J; Hamraoui, K; Dabrowska, K; de Nooijer, C; Groenenberg, I; Kietselae, BLJH; Muis, L; Hamer, BJB; Hobe, C; van Eck, JWM; Elzebroek, N; Tans, JGM; Stapel, AGT; Nierop, PR; Dirks, M; Kuijper, AFM; Schiks, M; de Groot, MR; Post, G; ten Berg, JM; Bras, R; Koolen, JJ; van Leur, L; Herrman, JPR; Roelse, A; Ebink, C; Jones, B; Lipsic, E; Couperus, M; Bogaard, K; Dijk, A; Pettersen, KI; Fortun, M; Gullestad, L; Stueflotten, W; Popovic, I; Sobye, ET; Hogalmen, G; German, M; Hysing, J; Flagstad, E; Slettom, G; Nordrehaug, JE; Isaksen, A; Graven, T; Haug, H; Sandvik, J; Thunhaug, H; Ronning, PB; Gravrok, B; Lappegard, KT; Enebakk, T; Ronnevik, P; Ronnevik, T; Hurtig, U; Skanke, E; Omland, T; Tobiassen, GM; Berrospi, P; Ragas, Y; Bustamante, G; Marruffo, Y; Chavez, E; Chaname, A; Heredia, J; Gamero, K; Lema, J; Carrion, AM; Rodriguez, V; Cabanillas, N; Rodriguez, A; Zena, N; Segura, L; Rojas, C; Toce, L; Carrera, J; Orihuela, B; Del Portal, M; Roldan, Y; Roldan, G; Rodriguez, J; Chavez, C; Luna, G; Parra, J; Ramos, J; Mogrovejo, W; Godoy, J; Talledo, MZ; Diestra, J; Godoy, A; Matta, M; Pino, C; Vergara, R; Chois, A; Guillen, AM; Medina, J; Chirinos, J; Paredes, A; Quiroz, M; Camacho, L; Gil, M; Cerbito, S; Beltran, J; Tanglao, M; Uy, N; Busa, J; Rogelio, G; Arbis, MG; Prado, JP; Miranda, M; Sulit, DJ; Dioquino, R; Sevilla, R; Soriano, RA; Rosita, RR; Amazona, A; Atilano, A; Lim, E; Ebo, G; Maglasang, P; Palmes, P; Loreno, CA; Tirador, L; Alagban, C; Roxas, DJ; Roxas, JF; Cheng, F; De Guzman, S; Morales, D; Mararac, T; Barbas, B; Barbas, K; Ferrolino, A; Baysac, C; Llarena, AC; Julianes, C; Torun, A; Dalkowski, M; Widejko, K; Derlaga, B; Laskowska, E; Dudek, D; Dziewierz, A; Jozwa, R; Busz-Papiez, B; Pawlowicz, L; Kaczmarczyk, M; Jaworska, K; Skonieczny, G; Kopaczewski, J; Wujkowski, M; Krasowski, W; Krzyzanek, P; Kubica, J; Kozinski, M; Miekus, P; Glaza, M; Podolec, P; Wilkolek, P; Piepiorka, M; Piepiorka-Broniecka, M; Pluta, W; Ploch, M; Rynkiewicz, A; Mosakowska, K; Szpajer, M; Lesinski, D; Szwed, H; Jasek, S; Sciborski, R; Piotrowicz, R; Musial, W; Lisowska, A; Rekosz, J; Kasznicka, M; Korzeniak, R; Staneta, P; Konczakowski, P; Waluszek-Konczakowska, I; Cymerman, K; Lubinski, A; Grycewicz, T; Hiczkiewicz, J; Plucinski, M; Korol, M; Szczech, J; Hawro, M; Skorski, M; Cichon, K; Jankowski, M; Cygler, J; Ottomanska-Cygler, M; Korecki, J; Gulaj, E; Zechowicz, T; Zechowicz, M; Goch, A; Topolinski, B; Ogorek, M; Szczepanska, A; Wojewoda, P; Jagoda, E; Krzyzanowski, W; Muzyk-Osikowicz, M; Jaszczurowski, W; Stasiewski, A; Wietrzynska, J; Miklaszewicz, B; Beme, A; Sudnik, W; Matys, U; Ponikowski, P; Powierza, S; Kim, YH; Choi, DJ; Seung, KB; Lim, DS; Lee, SH; Kim, HS; Bae, JH; Hong, TJ; Hong, MK; Tahk, SJ; Kim, YJ; Yoon, J; Jeong, MH; Chae, JK; Cho, MC; Hong, SK; Hur, SH; Jeong, JO; Her, SH; Lee, JM; Chang, KC; Yoon, CH; Chang, K; Park, J; Choi, S; Park, K; Bae, Y; Lee, H; Kim, BK; Yoon, MH; Park, JS; Jang, H; Kim, C; Cho, EJ; Bae, J; Lee, D; Lee, J; Choi, YY; Dimulescu, D; Vintila, M; Fruntelata, A; Pirvu, O; Stanciulescu, G; Giuca, A; Militaru, C; Radoi, M; Bobescu, E; Crisu, D; Creteanu, M; Minescu, B; Bolohan, F; Manitiu, I; Bengus, C; Iosipescu, L; Ciobotaru, V; Basarab, G; Benedek, I; Constantinescu, M; Cristea, M; Capalneanu, R; Tatu-Chitoiu, G; Huidu, S; Protopopescu, L; Greavu, M; Diaconu, M; Blajan, D; Istratoaie, O; Lican, G; Bisoc, A; Doka, B; Jemna, D; Parasteac, M; Serban, L; Mihai, M; Cioca, G; Ochean, V; Costache, L; Andor, M; Stoica, D; Benedek, T; Sava, N; Anciu, M; Mot, S; Cornaciu, S; Boldueva, S; Golitsyn, S; Karpov, Y; Kobalava, Z; Konstantinov, V; Kuimov, A; Ezhov, M; Panov, A; Novikova, T; Simanenkov, V; Smolenskaya, O; Tsyba, L; Vishnevsky, A; Yakhontova, P; Kislyak, O; Demchenko, E; Yakovlev, A; Ermoshkina, L; Arkhipov, M; Galyavich, A; Strongin, L; Kosmacheva, E; Goloshchekin, B; Sidorenko, B; Izmozherova, N; Shustov, S; Orlikova, O; Lukyanov, Y; Koziolova, N; Nedogoda, S; Statsenko, M; Kotelnikov, M; Osipenko, M; Oshchepkova, E; Bolieva, L; Ryamzina, I; Pavlysh, E; Samokhvalova, M; Mironova, N; Buza, V; Shavarov, A; Serebrenitskaya, M; Khomyakova, L; Safarova, M; Lohovinina, N; Staroverov, I; Bitakova, F; Zakharova, N; Khurs, E; Belenky, D; Kositsyn, D; Rovnykh, Y; Kasatova, T; Lubinskaya, E; Omelchenko, M; Slukhaenko, I; Kozulin, A; Baleeva, L; Pochinka, I; Kizhvatova, N; Laptev, I; Bugrimova, M; Popov, A; Kovalevskaya, E; Orlikov, E; Paltsman, Z; Lamden, D; Surovtseva, M; Tsoma, V; Derevjanchenko, M; Streltsov, S; Bikbulatova, E; Dmitriev, V; Byazrova, S; Khovaeva, Y; Komandenko, O; Dlesk, A; Urban, M; Vinanska, D; Dzupina, A; Hranai, M; Cisar, P; Toth, P; Paulov, S; Sivak, V; Bolvanska, N; Pella, D; Palka, J; Nedelova, I; Benacka, J; Gergel, V; Hatalova, K; Kohut, P; Kovar, F; Knazeje, M; Macek, V; Sinska, R; Bugan, V; Badenhorst, JCW; Erasmus, L; Burgess, LJ; de Necker, I; Corbett, CH; Fouche, L; Dawood, SY; Conradie, C; Delport, EF; Kruger, M; Ebrahim, I; Bobak, C; Nethononda, MR; Nunkoo, T; van Rensburg, FPJ; Middle, R; Horak, AR; Henley, L; Mabin, TA; King, A; Ranjith, N; Ramdas, S; Roodt, A; Coetsee, E; Theron, H; Karsten, M; Van Zyl, LJ; Roscher, M; Venter, TP; de Kock, L; Becker, AC; Swanepoel, J; Ismail, SM; Dalby, AJ; Allman, J; Roux, JP; Christie, H; Naidoo, DP; Vawda, GHM; Manga, P; Olckers, W; Mpe, MT; Farrell, BM; Areses, ELD; Lopez, SV; Fernandez, JMC; Roldan, JG; Pavia, PG; Segovia, AG; Puig, JG; Garcia, VC; Aguilera, RM; Munoa, MD; Cortada, JB; Cereto, PC; Perez, IP; Cid, LP; Basilio, EG; Guerra, PC; Ortiz, AF; Balcones, LDV; Vera, TR; Martinez, JMG; Galvan, ED; Caballero, AH; Blanco, VMR; Lopez, JMR; Franco, MRP; Soriano, FR; Porcar, LC; Fillat, ARC; Moreno, SG; Montejano, MG; Guerrero, JMD; Coronado, JLB; Eizagaechevarria, NM; Araucua, GN; Rubio, AM; Roca, MC; Marimon, XGM; Perales, MV; Gonzalez, AB; Sastre, MP; Juanatey, JRG; Acuna, JMG; Al-Khalili, F; Lof, P; Bandh, S; Myllyla, L; Christensen, K; Johansson, K; Dellborg, M; Hultsberg-Olsson, G; Alstrom, P; Damm, TL; Erlinge, D; Brolin, G; Ravn-Fischer, PA; Johansson, P; Andreen, S; Linderfalk, C; Ram, B; Lindholm, CJ; Assarsson, E; Mooe, T; Lindberg, A; Paren, P; Moodh, J; Svensson, P; Andersson, I; Wodlin, P; Raschperger, A; Skogvard, P; Koch, A; Lind, N; Osberg, L; Nilsson, C; Svensson, K; Bengtsson, M; Samad, B; Nilsson, M; Berglund, E; Lundgren, C; Lindmark, K; Sundholm, C; Aladellie, L; Welin-Berger, B; Guneri, S; Dogan, NB; Ersanli, M; Coskun, U; Cayli, M; Seker, T; Camsari, A; Ozcan, T; Ongen, Z; Karadag, B; Boyaci, B; Sezenoz, B; Pekdemir, H; Hidayet, S; Erol, M; Yalcin, A; Sezer, M; Emet, S; Bozkurt, E; Ozen, MB; Lutay, Y; Dyadyk, O; Kholopov, L; Rudyk, I; Shaposhnikova, Y; Chopey, I; Ternuschak, T; Reshotko, D; Popova, G; Batushkin, V; Gema, A; Vizir, V; Berezyn, O; Lutai, M; Tovstukha, V; Shumakov, V; Pogurelska, O; Sirenko, Y; Rekovets, O; Kraiz, I; Kamenska, E; Tseluyko, V; Yakovleva, L; Yena, L; Artemenko, V; Koval, O; Kaplan, P; Karpenko, O; Nevolina, I; Bazilevych, A; Harbar, M; Rudenko, L; Beregova, O; Mostovyi, Y; Rasputina, L; Vatutin, M; Shevelok, A; Kovalenko, V; Polenova, N; Amosova, K; Tkachenko, L; Volkov, V; Zaprovalna, O; Storey, R; Thomas, M; Pell, A; Moriarty, A; Kinnin, M; Ahsan, A; Burton, J; ORourke, B; Young, J; Lang, C; Forbes, J; Rowlands, D; Hamill, S; Sprigings, D; Cadd, A; de Belder, M; Atkinson, B; Ramsey, M; Fagan, JC; Pye, M; Wright, L; Keeling, P; Hughes, D; Fraser, D; Phillips, H; Muthusamy, R; Lawan, M; Levy, T; Kennard, S; Bodalia, B; Mottram, J; Calvert, J; Brodie, K; Gunstone, A; Douglas, C; Trouton, T; Hunter, B; Gerber, R; Pepper, H; Mathur, A; Andiapen, M; Baumbach, A; Bowles, R; Hildick-Smith, D; McGregor, A; Loh, I; Plocky, J; Adams, K; Clemmer, K; Aggarwal, K; Burkhardt, V; Costa, M; Lemmertz, K; Anderson, J; York, T; Angiolillo, D; Green, E; Sperling, M; Vasquez, E; Aycock, G; Tatum, D; Amin, J; Davidson, A; Hendrix, E; Shepard, L; Strain, J; Michel, K; Talano, J; Szalanski, N; Berk, M; Ibarra, M; Bhagwat, R; Winterrowd, D; Bilazarian, S; Marsters, M; Blonder, R; Graf, L; Brilakis, E; Roesle, M; Byrd, L; Sullivan, A; Longo, J; Pennella, A; Westerhausen, D; Weil, R; Carr, K; Piazza, J; Carr, KW; Castello, R; Hawks, M; Chandna, H; Holly, D; Chandrashekhar, YS; Molinaro, N; Carter, M; Antonino, M; Kosmicki, D; Kelley, M; Richwine, R; Pazier, P; Glasgow, B; Bresee, S; Alexander, J; Concha, M; Martinez, E; Connelly, T; Schenks, R; Cooper, M; Garman, V; Condit, J; White, A; Fialkow, J; Mckercher, M; Luna, M; Soto, G; Prodafikas, J; Rambaud, B; Donovan, J; Mudd, D; Doty, W; Parsons, T; D'Urso, M; Bies, J; Han, J; Treadwell, M; Erickson, B; Dahl, P; Fattal, P; Braem, J; Felten, W; Prior, J; French, W; Barillas, O; Berger, R; Genova, E; Gelernt, M; Cockrell, D; Miller, G; Dumka, K; Gill, S; Elliot, S; Goldberg, R; Barrett, M; Gordon, P; Stern, L; Ayres, T; Rhule, V; Gupta, D; Holton, T; Haddad, T; Jain, J; Hakas, J; McSorley, J; Hamroff, G; Hollenweger, L; Wainwright, W; Jones, S; Casagrande, M; Casagrande, MG; Effat, M; Mardis, R; Henderson, D; Millard, D; Hermany, P; Meissner-Dengler, S; Hinchman, D; Luck, K; Hodson, R; Severson, L; Horwitz, P; Miller, K; Isserman, S; Moore, C; Jan, M; Bilyk, O; Kersh, R; DaCosta, A; Kim, E; Gonzales, C; Kmetzo, J; Taylor, D; Knutson, T; Belanger, B; Hage-Korban, E; Harrington, A; Murdock, D; Heiman, M; Dandekar, U; Khan, M; Khan, G; Lui, H; Holman, L; MacDonald, L; Derbyshire, S; Watkins, K; Mayer, N; Mitchell, B; McCullum, K; Delio-Cox, B; Mckay, R; Cloutier, J; McKenzie, M; Rodkey, K; McLaurin, B; Lack, A; Minisi, A; Jeter, D; Mitchell, R; Keane-Richmond, P; Stine, R; Bullivant, M; Morford, R; White, J; Oberoi, M; Geraldo-Abache, A; O'Dea, D; Mehta, R; Tang, N; Ong, S; Edwards, M; Osborne, J; Alonzo, C; Lev, V; Monroe, J; Popeil, L; Sorrentino, N; Portelli, J; Landi, T; Potu, R; Smith, N; Prashad, R; McDonough, C; Qureshi, M; Howe, A; Raikhel, M; Arsate, M; Rogers, W; Saag, L; Sangrigoli, R; Schwarz, L; Abu-Fadel, M; Hagee, A; Kinnaman, S; McDaniel, V; Wilson, V; Purcell, T; Roberts, J; Riofrio, K; Shah, U; Narang, S; Gredler, F; Knap, P; Shanes, J; Hansen, C; Sharma, M; Gibson, T; Sheldon, W; Bohn, A; Siegel, C; Tibbits, L; Singh, V; Nelson, M; Singh, N; Logwood, D; Randhawa, P; Vargas, B; Stegemoller, R; Cole, B; Aggarwal, R; Johnson, M; Steinhoff, J; Dunaway, B; Patel, K; Boomer, L; Taheri, H; Morgan, K; Tahirkheli, N; Santos, A; Thadani, U; Alexander, D; Bennett, W; Kelley, E; Thomas, J; Macnicholas, D; Varma, S; Evans, S; Vlastaris, A; Bittel, B; Voyce, S; Mack, B; Weiss, R; Fournier, T; Whitney, R; Orosco, C; Willis, J; VonGerichten, S; Wiseman, A; Sharrow, A; Wohns, D; Schuitema, J; Amin, M; Ramus, A; Wilson, W; Moeller, C; Newell, M; Tindell, L; Rivera, W; Kwierant, J; Bretton, E; Corbin, B; Labroo, A; Lopez, C; Brown, C; Craig, M; Lucca, M; Keinanen, T; Eisenberg, S; Fielding, M; Doorey, A; Squire, A; Suresh, D; Frost, J; Teklinski, A; Stone, B; Waksman, R; Griffin, S; Wharton, W; Blakely, J; Fishbein, G; Weller, C; Camp, A; Fisher, S; Meholick, A; Hejna, E; Anderson, R; Long, S; Parikh, S; Norton, N; Vijay, N; Washam, M; Smith, S; Stepanov, N
Tipo de documento: Artículo
Estado:Published version
Fecha de publicación:2015
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p14507
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14507
Nivel de acceso:Acceso abierto
Descripción
Sumario:BACKGROUND The potential benefit of dual antiplatelet therapy beyond 1 year after a myocardial infarction has not been established. We investigated the efficacy and safety of ticagrelor, a P2Y(12) receptor antagonist with established efficacy after an acute coronary syndrome, in this context. METHODS We randomly assigned, in a double-blind 1: 1: 1 fashion, 21,162 patients who had had a myocardial infarction 1 to 3 years earlier to ticagrelor at a dose of 90 mg twice daily, ticagrelor at a dose of 60 mg twice daily, or placebo. All the patients were to receive low-dose aspirin and were followed for a median of 33 months. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The primary safety end point was Thrombolysis in Myocardial Infarction (TIMI) major bleeding. RESULTS The two ticagrelor doses each reduced, as compared with placebo, the rate of the primary efficacy end point, with Kaplan-Meier rates at 3 years of 7.85% in the group that received 90 mg of ticagrelor twice daily, 7.77% in the group that received 60 mg of ticagrelor twice daily, and 9.04% in the placebo group (hazard ratio for 90 mg of ticagrelor vs. placebo, 0.85; 95% confidence interval [CI], 0.75 to 0.96; P = 0.008; hazard ratio for 60 mg of ticagrelor vs. placebo, 0.84; 95% CI, 0.74 to 0.95; P = 0.004). Rates of TIMI major bleeding were higher with ticagrelor (2.60% with 90 mg and 2.30% with 60 mg) than with placebo (1.06%) (P < 0.001 for each dose vs. placebo); the rates of intracranial hemorrhage or fatal bleeding in the three groups were 0.63%, 0.71%, and 0.60%, respectively. CONCLUSIONS In patients with a myocardial infarction more than 1 year previously, treatment with ticagrelor significantly reduced the risk of cardiovascular death, myocardial infarction, or stroke and increased the risk of major bleeding. (Funded by AstraZeneca; PEGASUS-TIMI 54 ClinicalTrials.gov number, NCT01225562.)