Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis
This observational, longitudinal retrospective, noncomparative study was designed to assess the persistence and effectiveness of golimumab as a second anti-tumor necrosis factor (TNF) drug in patients with spondyloarthritis requiring discontinuation from a first anti-TNF drug.Data were collected ret...
| Authors: | ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Publication date: | 2021 |
| Country: | España |
| Institution: | Universitat Autònoma de Barcelona |
| Repository: | Dipòsit Digital de Documents de la UAB |
| Language: | English |
| OAI Identifier: | oai:ddd.uab.cat:272006 |
| Online Access: | https://ddd.uab.cat/record/272006 https://dx.doi.org/urn:doi:10.1097/MD.0000000000025223 |
| Access Level: | Open access |
| Keyword: | Ankylosing spondylitis Anti- tumor necrosis factor Golimumab Psoriatic arthritis Spondyloarthritis Tumor necrosis factor inhibitor |
| _version_ | 1878740346311016448 |
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| author | Alegre-Sancho, Juan José|||0000-0003-1641-0875 |
| author2 | Juanola, Xavier|||0000-0001-5998-6300 Rodriguez-Heredia, José Manuel|||0000-0002-4493-1419 Manero, Javier Villa-Blanco, Ignacio Laiz, Ana|||0000-0002-2820-4801 Arteaga, María J. Cea-Calvo, Luis González, Carlos M.|||0000-0001-5511-8274 |
| author2_role | author author author author author author author author |
| author_browse | Alegre-Sancho, Juan José|||0000-0003-1641-0875 Arteaga, María J. Cea-Calvo, Luis González, Carlos M.|||0000-0001-5511-8274 Juanola, Xavier|||0000-0001-5998-6300 Laiz, Ana|||0000-0002-2820-4801 Manero, Javier Rodriguez-Heredia, José Manuel|||0000-0002-4493-1419 Villa-Blanco, Ignacio |
| author_facet | Alegre-Sancho, Juan José|||0000-0003-1641-0875 Juanola, Xavier|||0000-0001-5998-6300 Rodriguez-Heredia, José Manuel|||0000-0002-4493-1419 Manero, Javier Villa-Blanco, Ignacio Laiz, Ana|||0000-0002-2820-4801 Arteaga, María J. Cea-Calvo, Luis González, Carlos M.|||0000-0001-5511-8274 |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | This observational, longitudinal retrospective, noncomparative study was designed to assess the persistence and effectiveness of golimumab as a second anti-tumor necrosis factor (TNF) drug in patients with spondyloarthritis requiring discontinuation from a first anti-TNF drug.Data were collected retrospectively for all patients with axial spondyloarthritis or psoriatic arthritis from 20 rheumatology clinics in Spain who started golimumab as a second anti-TNF drug between January 2013 and December 2015. Golimumab persistence was assessed with Kaplan-Meier survival analysis, and associated factors were assessed with Cox regression analysis.210 patients started golimumab as a second anti-TNF drug: 131 with axial spondyloarthritis and 79 with psoriatic arthritis. In axial spondyloarthritis patients, the mean (standard deviation) Bath Ankylosing Spondylitis Disease Activity Index score at baseline was 5.5 (2.1), decreasing to 3.9 (2.0) at month 3 and 3.5 (2.0) at year 1, and remaining stable thereafter. In psoriatic arthritis patients, mean (standard deviation) baseline Disease Activity Score was 4.0 (1.3), reducing to 2.5 (1.2) at month 3 and to 2.2 (1.3) at year 1. Corresponding improvements were recorded from baseline in C-reactive protein levels and erythrocyte sedimentation rates. The probability of persistence of treatment with golimumab was 80% at year 1, 70% at year 2 and 65% at years 3 and year 4, and was similar in those who had stopped the first anti-TNF due to loss of efficacy or other reasons. Cox regression analysis showed that the probability of survival with golimumab was higher in patients with higher erythrocyte sedimentation rate, in patients with axial spondyloarthritis than with psoriatic arthritis, and in those who had discontinued adalimumab as first anti-TNF. Seventy-two patients (34.3%) discontinued golimumab during follow-up, 50 of them due to lack of efficacy.In patients with spondyloarthritis requiring discontinuation from a first anti-TNF drug, treatment with golimumab was effective and showed a high probability of persistence up to 4years of treatment. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_d16129d8ca4479110a018adb0def49b4 |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:272006 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis A retrospective study Alegre-Sancho, Juan José|||0000-0003-1641-0875 Juanola, Xavier|||0000-0001-5998-6300 Rodriguez-Heredia, José Manuel|||0000-0002-4493-1419 Manero, Javier Villa-Blanco, Ignacio Laiz, Ana|||0000-0002-2820-4801 Arteaga, María J. Cea-Calvo, Luis González, Carlos M.|||0000-0001-5511-8274 Ankylosing spondylitis Anti- tumor necrosis factor Golimumab Psoriatic arthritis Spondyloarthritis Tumor necrosis factor inhibitor This observational, longitudinal retrospective, noncomparative study was designed to assess the persistence and effectiveness of golimumab as a second anti-tumor necrosis factor (TNF) drug in patients with spondyloarthritis requiring discontinuation from a first anti-TNF drug.Data were collected retrospectively for all patients with axial spondyloarthritis or psoriatic arthritis from 20 rheumatology clinics in Spain who started golimumab as a second anti-TNF drug between January 2013 and December 2015. Golimumab persistence was assessed with Kaplan-Meier survival analysis, and associated factors were assessed with Cox regression analysis.210 patients started golimumab as a second anti-TNF drug: 131 with axial spondyloarthritis and 79 with psoriatic arthritis. In axial spondyloarthritis patients, the mean (standard deviation) Bath Ankylosing Spondylitis Disease Activity Index score at baseline was 5.5 (2.1), decreasing to 3.9 (2.0) at month 3 and 3.5 (2.0) at year 1, and remaining stable thereafter. In psoriatic arthritis patients, mean (standard deviation) baseline Disease Activity Score was 4.0 (1.3), reducing to 2.5 (1.2) at month 3 and to 2.2 (1.3) at year 1. Corresponding improvements were recorded from baseline in C-reactive protein levels and erythrocyte sedimentation rates. The probability of persistence of treatment with golimumab was 80% at year 1, 70% at year 2 and 65% at years 3 and year 4, and was similar in those who had stopped the first anti-TNF due to loss of efficacy or other reasons. Cox regression analysis showed that the probability of survival with golimumab was higher in patients with higher erythrocyte sedimentation rate, in patients with axial spondyloarthritis than with psoriatic arthritis, and in those who had discontinued adalimumab as first anti-TNF. Seventy-two patients (34.3%) discontinued golimumab during follow-up, 50 of them due to lack of efficacy.In patients with spondyloarthritis requiring discontinuation from a first anti-TNF drug, treatment with golimumab was effective and showed a high probability of persistence up to 4years of treatment. https://ddd.uab.cat/record/272006 https://dx.doi.org/urn:doi:10.1097/MD.0000000000025223 |
| spellingShingle | Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis Alegre-Sancho, Juan José|||0000-0003-1641-0875 Ankylosing spondylitis Anti- tumor necrosis factor Golimumab Psoriatic arthritis Spondyloarthritis Tumor necrosis factor inhibitor |
| title | Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis |
| title_full | Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis |
| title_fullStr | Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis |
| title_full_unstemmed | Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis |
| title_short | Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis |
| title_sort | Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis |
| topic | Ankylosing spondylitis Anti- tumor necrosis factor Golimumab Psoriatic arthritis Spondyloarthritis Tumor necrosis factor inhibitor |
| topic_facet | Ankylosing spondylitis Anti- tumor necrosis factor Golimumab Psoriatic arthritis Spondyloarthritis Tumor necrosis factor inhibitor |
| url | https://ddd.uab.cat/record/272006 https://dx.doi.org/urn:doi:10.1097/MD.0000000000025223 |