Ideal cardiovascular health and inflammation in European adolescents: The HELENA study

Background and aims Inflammation plays a key role in atherosclerosis and this process seems to appear in childhood. The ideal cardiovascular health index (ICHI) has been inversely related to atherosclerotic plaque in adults. However, evidence regarding inflammation and ICHI in adolescents is scarce....

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Authors: González-Gil, E.M.; Santabárbara, J.; Ruiz, J.R.; Bel-Serrat, S.; Huybrechts, I.; Pedrero-Chamizo, R.; de la O, A.; Gottrand, F.; Kafatos, A.; Widhalm, K.; Manios, Y.; Molnar, D.; de Henauw, S.; Plada, M.; Ferrari, M.; Palacios Le Blé, G.; Siani, A.; González-Gross, M.; Gómez-Martínez, S.; Marcos, A.; Moreno Aznar, L.A.; Moreno, L.A.; Gilbert, C.; Libersa, C.; Castelló, S.; Kersting, M.; Sjöstrom, M.; Molnár, D.; Dallongeville, J.; Hall, G.; Maes, L.; Scalfi, L.; Meléndez, P.; Fleta, J.; Casajús, J.A.; Rodríguez, G.; Tomás, C.; Mesana, M.I.; Vicente-Rodríguez, G.; Villarroya, A.; Gil, C.M.; Ara, I.; Alvira, J.F.; Bueno, G.; Lázaro, A.; Bueno, O.; León, J.F.; Garagorri, J.M.; Bueno, M.; Labayen, I.; Iglesia, I.; Bel Serrat, S.; Gracia Marco, L.A.; Mouratidou, T.; Santaliestra-Pasías, A.; de Miguel-Etayo, P.; Julián Almárcegui, C.; Miguel-Berges, M.; Iguacel, I.; Wärnberg, J.; Nova, E.; Gómez, S.; Díaz, L.E.; Romeo, J.; Veses, A.; Zapatera, B.; Pozo, T.; Martínez, D.; Beghin, L.; Iliescu, C.; Von Berlepsch, J.; Sichert-Hellert, W.; Koeppen, E.; Erhardt, E.; Csernus, K.; Török, K.; Bokor, S.; Angster.; Nagy, E.Ö.; Kovács, O.; Répasi, J.; Codrington, C.; Papadaki, A.; Sarri, K.; Viskadourou, A.; Hatzis, C.; Kiriakakis, M.; Tsibinos, G.; Vardavas, C.; Sbokos, M.; Protoyeraki, E.; Fasoulaki, M.; Stehle, P.; Pietrzik, K.; Breidenassel, C.; Spinneker, A.; Al-Tahan, J.; Segoviano, M.; Berchtold, A.; Bierschbach, C.; Blatzheim, E.; Schuch, A.; Pickert, P.; Castillo, M.J.; Gutiérrez, Á.; Ortega, F.B.; Artero, E.G.; España, V.; Jiménez-Pavón, D.; Chillón, P.; Sánchez-Muñoz, C.; Cuenca, M.; Arcella, D.; Azzini, E.; Barrison, E.; Bevilacqua, N.; Buonocore, P.; Catasta, G.; Censi, L.; Ciarapica, D.; D''Acapito, P.; Galfo, M.; Le Donne, C.; Leclercq, C.; Maiani, G.; Mauro, B.; Mistura, L.; Pasquali, A.; Piccinelli, R.; Polito, A.; Roccaldo, R.; Spada, R.; Sette, S.; Zaccaria, M.; Vitaglione, P.; Montagnese, C.; De Bourdeaudhuij, I.; De Vriendt, T.; Matthys, C.; Vereecken, C.; de Maeyer, M.; Ottevaere, C.; Phillipp, K.; Dietrich, S.; Grammatikaki, E.; Bouloubasi, Z.; Cook, T.L.; Eleutheriou, S.; Consta, O.; Moschonis, G.; Katsaroli, I.; Kraniou, G.; Papoutsou, S.; Keke, D.; Petraki, I.; Bellou, E.; Tanagra, S.; Kallianoti, K.; Argyropoulou, D.; Tsikrika, S.; Karaiskos, C.; Meirhaeghe, A.; Hagströmer, M.; Wennlöf, A.H.; Hallström, L.; Patterson, E.; Kwak, L.; Rizzo, N.; Sánchez-Molero, J.; Picó, E.; Navarro, M.; Viadel, B.; Carreres, J.E.; Merino, G.; Sanjuán, R.; Lorente, M.; Sánchez, M.J.; Thomas, S.; Allchurch, E.; Burgess, P.; Astrom, A.; Sverkén, A.; Broberg, A.; Masson, A.; Lehoux, C.; Brabant, P.; Pate, P.; Fontaine, L.; Sebok, A.; Kuti, T.; Hegyi, A.; Maldonado, C.; Llorente, A.; García, E.; von Fircks, H.; Hallberg, M.L.; Messerer, M.; Larsson, M.
Format: Article
Status:Accepted version
Publication date:2017
Country:España
Institution:Universidad de Zaragoza
Repository:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:76024
Online Access:http://zaguan.unizar.es/record/76024
Access Level:Open access
_version_ 1878740309325643776
author González-Gil, E.M.
author2 Santabárbara, J.
Ruiz, J.R.
Bel-Serrat, S.
Huybrechts, I.
Pedrero-Chamizo, R.
de la O, A.
Gottrand, F.
Kafatos, A.
Widhalm, K.
Manios, Y.
Molnar, D.
de Henauw, S.
Plada, M.
Ferrari, M.
Palacios Le Blé, G.
Siani, A.
González-Gross, M.
Gómez-Martínez, S.
Marcos, A.
Moreno Aznar, L.A.
Moreno, L.A.
Gilbert, C.
Libersa, C.
Castelló, S.
Kersting, M.
Sjöstrom, M.
Molnár, D.
Dallongeville, J.
Hall, G.
Maes, L.
Scalfi, L.
Meléndez, P.
Fleta, J.
Casajús, J.A.
Rodríguez, G.
Tomás, C.
Mesana, M.I.
Vicente-Rodríguez, G.
Villarroya, A.
Gil, C.M.
Ara, I.
Alvira, J.F.
Bueno, G.
Lázaro, A.
Bueno, O.
León, J.F.
Garagorri, J.M.
Bueno, M.
Labayen, I.
Iglesia, I.
Bel Serrat, S.
Gracia Marco, L.A.
Mouratidou, T.
Santaliestra-Pasías, A.
de Miguel-Etayo, P.
Julián Almárcegui, C.
Miguel-Berges, M.
Iguacel, I.
Wärnberg, J.
Nova, E.
Gómez, S.
Díaz, L.E.
Romeo, J.
Veses, A.
Zapatera, B.
Pozo, T.
Martínez, D.
Beghin, L.
Iliescu, C.
Von Berlepsch, J.
Sichert-Hellert, W.
Koeppen, E.
Erhardt, E.
Csernus, K.
Török, K.
Bokor, S.
Angster.
Nagy, E.Ö.
Kovács, O.
Répasi, J.
Codrington, C.
Papadaki, A.
Sarri, K.
Viskadourou, A.
Hatzis, C.
Kiriakakis, M.
Tsibinos, G.
Vardavas, C.
Sbokos, M.
Protoyeraki, E.
Fasoulaki, M.
Stehle, P.
Pietrzik, K.
Breidenassel, C.
Spinneker, A.
Al-Tahan, J.
Segoviano, M.
Berchtold, A.
Bierschbach, C.
Blatzheim, E.
Schuch, A.
Pickert, P.
Castillo, M.J.
Gutiérrez, Á.
Ortega, F.B.
Artero, E.G.
España, V.
Jiménez-Pavón, D.
Chillón, P.
Sánchez-Muñoz, C.
Cuenca, M.
Arcella, D.
Azzini, E.
Barrison, E.
Bevilacqua, N.
Buonocore, P.
Catasta, G.
Censi, L.
Ciarapica, D.
D''Acapito, P.
Galfo, M.
Le Donne, C.
Leclercq, C.
Maiani, G.
Mauro, B.
Mistura, L.
Pasquali, A.
Piccinelli, R.
Polito, A.
Roccaldo, R.
Spada, R.
Sette, S.
Zaccaria, M.
Vitaglione, P.
Montagnese, C.
De Bourdeaudhuij, I.
De Vriendt, T.
Matthys, C.
Vereecken, C.
de Maeyer, M.
Ottevaere, C.
Phillipp, K.
Dietrich, S.
Grammatikaki, E.
Bouloubasi, Z.
Cook, T.L.
Eleutheriou, S.
Consta, O.
Moschonis, G.
Katsaroli, I.
Kraniou, G.
Papoutsou, S.
Keke, D.
Petraki, I.
Bellou, E.
Tanagra, S.
Kallianoti, K.
Argyropoulou, D.
Tsikrika, S.
Karaiskos, C.
Meirhaeghe, A.
Hagströmer, M.
Wennlöf, A.H.
Hallström, L.
Patterson, E.
Kwak, L.
Rizzo, N.
Sánchez-Molero, J.
Picó, E.
Navarro, M.
Viadel, B.
Carreres, J.E.
Merino, G.
Sanjuán, R.
Lorente, M.
Sánchez, M.J.
Thomas, S.
Allchurch, E.
Burgess, P.
Astrom, A.
Sverkén, A.
Broberg, A.
Masson, A.
Lehoux, C.
Brabant, P.
Pate, P.
Fontaine, L.
Sebok, A.
Kuti, T.
Hegyi, A.
Maldonado, C.
Llorente, A.
García, E.
von Fircks, H.
Hallberg, M.L.
Messerer, M.
Larsson, M.
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author_browse Al-Tahan, J.
Allchurch, E.
Alvira, J.F.
Angster.
Ara, I.
Arcella, D.
Argyropoulou, D.
Artero, E.G.
Astrom, A.
Azzini, E.
Barrison, E.
Beghin, L.
Bel Serrat, S.
Bel-Serrat, S.
Bellou, E.
Berchtold, A.
Bevilacqua, N.
Bierschbach, C.
Blatzheim, E.
Bokor, S.
Bouloubasi, Z.
Brabant, P.
Breidenassel, C.
Broberg, A.
Bueno, G.
Bueno, M.
Bueno, O.
Buonocore, P.
Burgess, P.
Carreres, J.E.
Casajús, J.A.
Castelló, S.
Castillo, M.J.
Catasta, G.
Censi, L.
Chillón, P.
Ciarapica, D.
Codrington, C.
Consta, O.
Cook, T.L.
Csernus, K.
Cuenca, M.
D''Acapito, P.
Dallongeville, J.
De Bourdeaudhuij, I.
De Vriendt, T.
Dietrich, S.
Díaz, L.E.
Eleutheriou, S.
Erhardt, E.
España, V.
Fasoulaki, M.
Ferrari, M.
Fleta, J.
Fontaine, L.
Galfo, M.
Garagorri, J.M.
García, E.
Gil, C.M.
Gilbert, C.
González-Gil, E.M.
González-Gross, M.
Gottrand, F.
Gracia Marco, L.A.
Grammatikaki, E.
Gutiérrez, Á.
Gómez, S.
Gómez-Martínez, S.
Hagströmer, M.
Hall, G.
Hallberg, M.L.
Hallström, L.
Hatzis, C.
Hegyi, A.
Huybrechts, I.
Iglesia, I.
Iguacel, I.
Iliescu, C.
Jiménez-Pavón, D.
Julián Almárcegui, C.
Kafatos, A.
Kallianoti, K.
Karaiskos, C.
Katsaroli, I.
Keke, D.
Kersting, M.
Kiriakakis, M.
Koeppen, E.
Kovács, O.
Kraniou, G.
Kuti, T.
Kwak, L.
Labayen, I.
Larsson, M.
Le Donne, C.
Leclercq, C.
Lehoux, C.
León, J.F.
Libersa, C.
Llorente, A.
Lorente, M.
Lázaro, A.
Maes, L.
Maiani, G.
Maldonado, C.
Manios, Y.
Marcos, A.
Martínez, D.
Masson, A.
Matthys, C.
Mauro, B.
Meirhaeghe, A.
Meléndez, P.
Merino, G.
Mesana, M.I.
Messerer, M.
Miguel-Berges, M.
Mistura, L.
Molnar, D.
Molnár, D.
Montagnese, C.
Moreno Aznar, L.A.
Moreno, L.A.
Moschonis, G.
Mouratidou, T.
Nagy, E.Ö.
Navarro, M.
Nova, E.
Ortega, F.B.
Ottevaere, C.
Palacios Le Blé, G.
Papadaki, A.
Papoutsou, S.
Pasquali, A.
Pate, P.
Patterson, E.
Pedrero-Chamizo, R.
Petraki, I.
Phillipp, K.
Piccinelli, R.
Pickert, P.
Picó, E.
Pietrzik, K.
Plada, M.
Polito, A.
Pozo, T.
Protoyeraki, E.
Rizzo, N.
Roccaldo, R.
Rodríguez, G.
Romeo, J.
Ruiz, J.R.
Répasi, J.
Sanjuán, R.
Santabárbara, J.
Santaliestra-Pasías, A.
Sarri, K.
Sbokos, M.
Scalfi, L.
Schuch, A.
Sebok, A.
Segoviano, M.
Sette, S.
Siani, A.
Sichert-Hellert, W.
Sjöstrom, M.
Spada, R.
Spinneker, A.
Stehle, P.
Sverkén, A.
Sánchez, M.J.
Sánchez-Molero, J.
Sánchez-Muñoz, C.
Tanagra, S.
Thomas, S.
Tomás, C.
Tsibinos, G.
Tsikrika, S.
Török, K.
Vardavas, C.
Vereecken, C.
Veses, A.
Viadel, B.
Vicente-Rodríguez, G.
Villarroya, A.
Viskadourou, A.
Vitaglione, P.
Von Berlepsch, J.
Wennlöf, A.H.
Widhalm, K.
Wärnberg, J.
Zaccaria, M.
Zapatera, B.
de Henauw, S.
de Maeyer, M.
de Miguel-Etayo, P.
de la O, A.
von Fircks, H.
author_facet González-Gil, E.M.
Santabárbara, J.
Ruiz, J.R.
Bel-Serrat, S.
Huybrechts, I.
Pedrero-Chamizo, R.
de la O, A.
Gottrand, F.
Kafatos, A.
Widhalm, K.
Manios, Y.
Molnar, D.
de Henauw, S.
Plada, M.
Ferrari, M.
Palacios Le Blé, G.
Siani, A.
González-Gross, M.
Gómez-Martínez, S.
Marcos, A.
Moreno Aznar, L.A.
Moreno, L.A.
Gilbert, C.
Libersa, C.
Castelló, S.
Kersting, M.
Sjöstrom, M.
Molnár, D.
Dallongeville, J.
Hall, G.
Maes, L.
Scalfi, L.
Meléndez, P.
Fleta, J.
Casajús, J.A.
Rodríguez, G.
Tomás, C.
Mesana, M.I.
Vicente-Rodríguez, G.
Villarroya, A.
Gil, C.M.
Ara, I.
Alvira, J.F.
Bueno, G.
Lázaro, A.
Bueno, O.
León, J.F.
Garagorri, J.M.
Bueno, M.
Labayen, I.
Iglesia, I.
Bel Serrat, S.
Gracia Marco, L.A.
Mouratidou, T.
Santaliestra-Pasías, A.
de Miguel-Etayo, P.
Julián Almárcegui, C.
Miguel-Berges, M.
Iguacel, I.
Wärnberg, J.
Nova, E.
Gómez, S.
Díaz, L.E.
Romeo, J.
Veses, A.
Zapatera, B.
Pozo, T.
Martínez, D.
Beghin, L.
Iliescu, C.
Von Berlepsch, J.
Sichert-Hellert, W.
Koeppen, E.
Erhardt, E.
Csernus, K.
Török, K.
Bokor, S.
Angster.
Nagy, E.Ö.
Kovács, O.
Répasi, J.
Codrington, C.
Papadaki, A.
Sarri, K.
Viskadourou, A.
Hatzis, C.
Kiriakakis, M.
Tsibinos, G.
Vardavas, C.
Sbokos, M.
Protoyeraki, E.
Fasoulaki, M.
Stehle, P.
Pietrzik, K.
Breidenassel, C.
Spinneker, A.
Al-Tahan, J.
Segoviano, M.
Berchtold, A.
Bierschbach, C.
Blatzheim, E.
Schuch, A.
Pickert, P.
Castillo, M.J.
Gutiérrez, Á.
Ortega, F.B.
Artero, E.G.
España, V.
Jiménez-Pavón, D.
Chillón, P.
Sánchez-Muñoz, C.
Cuenca, M.
Arcella, D.
Azzini, E.
Barrison, E.
Bevilacqua, N.
Buonocore, P.
Catasta, G.
Censi, L.
Ciarapica, D.
D''Acapito, P.
Galfo, M.
Le Donne, C.
Leclercq, C.
Maiani, G.
Mauro, B.
Mistura, L.
Pasquali, A.
Piccinelli, R.
Polito, A.
Roccaldo, R.
Spada, R.
Sette, S.
Zaccaria, M.
Vitaglione, P.
Montagnese, C.
De Bourdeaudhuij, I.
De Vriendt, T.
Matthys, C.
Vereecken, C.
de Maeyer, M.
Ottevaere, C.
Phillipp, K.
Dietrich, S.
Grammatikaki, E.
Bouloubasi, Z.
Cook, T.L.
Eleutheriou, S.
Consta, O.
Moschonis, G.
Katsaroli, I.
Kraniou, G.
Papoutsou, S.
Keke, D.
Petraki, I.
Bellou, E.
Tanagra, S.
Kallianoti, K.
Argyropoulou, D.
Tsikrika, S.
Karaiskos, C.
Meirhaeghe, A.
Hagströmer, M.
Wennlöf, A.H.
Hallström, L.
Patterson, E.
Kwak, L.
Rizzo, N.
Sánchez-Molero, J.
Picó, E.
Navarro, M.
Viadel, B.
Carreres, J.E.
Merino, G.
Sanjuán, R.
Lorente, M.
Sánchez, M.J.
Thomas, S.
Allchurch, E.
Burgess, P.
Astrom, A.
Sverkén, A.
Broberg, A.
Masson, A.
Lehoux, C.
Brabant, P.
Pate, P.
Fontaine, L.
Sebok, A.
Kuti, T.
Hegyi, A.
Maldonado, C.
Llorente, A.
García, E.
von Fircks, H.
Hallberg, M.L.
Messerer, M.
Larsson, M.
author_role author
collection Zaguán. Repositorio Digital de la Universidad de Zaragoza
description Background and aims Inflammation plays a key role in atherosclerosis and this process seems to appear in childhood. The ideal cardiovascular health index (ICHI) has been inversely related to atherosclerotic plaque in adults. However, evidence regarding inflammation and ICHI in adolescents is scarce. The aim is to assess the association between ICHI and inflammation in European adolescents. Methods and results As many as 543 adolescents (251 boys and 292 girls) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, a cross-sectional multi-center study including 9 European countries, were measured. C-reactive protein (CRP), complement factors C3 and C4, leptin and white blood cell counts were used to compute an inflammatory score. Multilevel linear models and multilevel logistic regression were used to assess the association between ICHI and inflammation controlling by covariates. Higher ICHI was associated with a lower inflammatory score, as well as with several individual components, both in boys and girls (p < 0.01). In addition, adolescents with at least 4 ideal components of the ICHI had significantly lower inflammatory score and lower levels of the study biomarkers, except CRP. Finally, the multilevel logistic regression showed that for every unit increase in the ICHI, the probability of having an inflammatory profile decreased by 28.1% in girls. Conclusion Results from this study suggest that a better ICHI is associated with a lower inflammatory profile already in adolescence. Improving these health behaviors, and health factors included in the ICHI, could play an important role in CVD prevention.
eu_rights_str_mv openAccess
format article
id ES_d0c10db623abc2d4ab64cf8d5dbaa8cd
institution Universidad de Zaragoza
instname_str Universidad de Zaragoza
network_acronym_str ES
network_name_str España
oai_identifier_str oai:zaguan.unizar.es:76024
publishDate 2017
publishDateSort 2017
reponame_str Zaguán. Repositorio Digital de la Universidad de Zaragoza
spelling Ideal cardiovascular health and inflammation in European adolescents: The HELENA study González-Gil, E.M. Santabárbara, J. Ruiz, J.R. Bel-Serrat, S. Huybrechts, I. Pedrero-Chamizo, R. de la O, A. Gottrand, F. Kafatos, A. Widhalm, K. Manios, Y. Molnar, D. de Henauw, S. Plada, M. Ferrari, M. Palacios Le Blé, G. Siani, A. González-Gross, M. Gómez-Martínez, S. Marcos, A. Moreno Aznar, L.A. Moreno, L.A. Gilbert, C. Libersa, C. Castelló, S. Kersting, M. Sjöstrom, M. Molnár, D. Dallongeville, J. Hall, G. Maes, L. Scalfi, L. Meléndez, P. Fleta, J. Casajús, J.A. Rodríguez, G. Tomás, C. Mesana, M.I. Vicente-Rodríguez, G. Villarroya, A. Gil, C.M. Ara, I. Alvira, J.F. Bueno, G. Lázaro, A. Bueno, O. León, J.F. Garagorri, J.M. Bueno, M. Labayen, I. Iglesia, I. Bel Serrat, S. Gracia Marco, L.A. Mouratidou, T. Santaliestra-Pasías, A. de Miguel-Etayo, P. Julián Almárcegui, C. Miguel-Berges, M. Iguacel, I. Wärnberg, J. Nova, E. Gómez, S. Díaz, L.E. Romeo, J. Veses, A. Zapatera, B. Pozo, T. Martínez, D. Beghin, L. Iliescu, C. Von Berlepsch, J. Sichert-Hellert, W. Koeppen, E. Erhardt, E. Csernus, K. Török, K. Bokor, S. Angster. Nagy, E.Ö. Kovács, O. Répasi, J. Codrington, C. Papadaki, A. Sarri, K. Viskadourou, A. Hatzis, C. Kiriakakis, M. Tsibinos, G. Vardavas, C. Sbokos, M. Protoyeraki, E. Fasoulaki, M. Stehle, P. Pietrzik, K. Breidenassel, C. Spinneker, A. Al-Tahan, J. Segoviano, M. Berchtold, A. Bierschbach, C. Blatzheim, E. Schuch, A. Pickert, P. Castillo, M.J. Gutiérrez, Á. Ortega, F.B. Artero, E.G. España, V. Jiménez-Pavón, D. Chillón, P. Sánchez-Muñoz, C. Cuenca, M. Arcella, D. Azzini, E. Barrison, E. Bevilacqua, N. Buonocore, P. Catasta, G. Censi, L. Ciarapica, D. D''Acapito, P. Galfo, M. Le Donne, C. Leclercq, C. Maiani, G. Mauro, B. Mistura, L. Pasquali, A. Piccinelli, R. Polito, A. Roccaldo, R. Spada, R. Sette, S. Zaccaria, M. Vitaglione, P. Montagnese, C. De Bourdeaudhuij, I. De Vriendt, T. Matthys, C. Vereecken, C. de Maeyer, M. Ottevaere, C. Phillipp, K. Dietrich, S. Grammatikaki, E. Bouloubasi, Z. Cook, T.L. Eleutheriou, S. Consta, O. Moschonis, G. Katsaroli, I. Kraniou, G. Papoutsou, S. Keke, D. Petraki, I. Bellou, E. Tanagra, S. Kallianoti, K. Argyropoulou, D. Tsikrika, S. Karaiskos, C. Meirhaeghe, A. Hagströmer, M. Wennlöf, A.H. Hallström, L. Patterson, E. Kwak, L. Rizzo, N. Sánchez-Molero, J. Picó, E. Navarro, M. Viadel, B. Carreres, J.E. Merino, G. Sanjuán, R. Lorente, M. Sánchez, M.J. Thomas, S. Allchurch, E. Burgess, P. Astrom, A. Sverkén, A. Broberg, A. Masson, A. Lehoux, C. Brabant, P. Pate, P. Fontaine, L. Sebok, A. Kuti, T. Hegyi, A. Maldonado, C. Llorente, A. García, E. von Fircks, H. Hallberg, M.L. Messerer, M. Larsson, M. Background and aims Inflammation plays a key role in atherosclerosis and this process seems to appear in childhood. The ideal cardiovascular health index (ICHI) has been inversely related to atherosclerotic plaque in adults. However, evidence regarding inflammation and ICHI in adolescents is scarce. The aim is to assess the association between ICHI and inflammation in European adolescents. Methods and results As many as 543 adolescents (251 boys and 292 girls) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, a cross-sectional multi-center study including 9 European countries, were measured. C-reactive protein (CRP), complement factors C3 and C4, leptin and white blood cell counts were used to compute an inflammatory score. Multilevel linear models and multilevel logistic regression were used to assess the association between ICHI and inflammation controlling by covariates. Higher ICHI was associated with a lower inflammatory score, as well as with several individual components, both in boys and girls (p < 0.01). In addition, adolescents with at least 4 ideal components of the ICHI had significantly lower inflammatory score and lower levels of the study biomarkers, except CRP. Finally, the multilevel logistic regression showed that for every unit increase in the ICHI, the probability of having an inflammatory profile decreased by 28.1% in girls. Conclusion Results from this study suggest that a better ICHI is associated with a lower inflammatory profile already in adolescence. Improving these health behaviors, and health factors included in the ICHI, could play an important role in CVD prevention. http://zaguan.unizar.es/record/76024
spellingShingle Ideal cardiovascular health and inflammation in European adolescents: The HELENA study
González-Gil, E.M.
status_str acceptedVersion
title Ideal cardiovascular health and inflammation in European adolescents: The HELENA study
title_full Ideal cardiovascular health and inflammation in European adolescents: The HELENA study
title_fullStr Ideal cardiovascular health and inflammation in European adolescents: The HELENA study
title_full_unstemmed Ideal cardiovascular health and inflammation in European adolescents: The HELENA study
title_short Ideal cardiovascular health and inflammation in European adolescents: The HELENA study
title_sort Ideal cardiovascular health and inflammation in European adolescents: The HELENA study
url http://zaguan.unizar.es/record/76024