Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia.
Both genetic and environmental factors have been found to play a significant role in psychosis relapse, either independently or through their synergistic interaction. Recently, DNA methylation (DNAm) has been proposed through the calculation of methylation profile scores (MPS). The aim of the presen...
| Autores: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/227759 |
| Acceso en línea: | https://hdl.handle.net/2445/227759 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Esquizofrènia Metilació Epigenètica Schizophrenia Methylation Epigenetics |
| _version_ | 1878740094853054465 |
|---|---|
| author | González Segura, Àlex |
| author2 | Prohens Coll, Llucia Julià, Laura Amoretti Guadall, Silvia RIbero Rodríguez, Maria Pino Camacho, Laura Cano Escalera, Guillermo Mané, Anna Rodriguez Jimenez, Roberto Roldán, Alexandra Sarró, Salvador Ibáñez Cuadrado, Ángela Usall i Rodié, Judith Lobo, Antonio García Rizo, Clemente Cuesta, Manuel J. Parellada, Mara González-Pinto, Ana Berrocoso, Esther Bernardo Arroyo, Miquel Mas Herrero, Sergi Rodríguez Ferret, Natalia |
| author2_role | author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Amoretti Guadall, Silvia Bernardo Arroyo, Miquel Berrocoso, Esther Cano Escalera, Guillermo Cuesta, Manuel J. García Rizo, Clemente González Segura, Àlex González-Pinto, Ana Ibáñez Cuadrado, Ángela Julià, Laura Lobo, Antonio Mané, Anna Mas Herrero, Sergi Parellada, Mara Pino Camacho, Laura Prohens Coll, Llucia RIbero Rodríguez, Maria Rodriguez Jimenez, Roberto Rodríguez Ferret, Natalia Roldán, Alexandra Sarró, Salvador Usall i Rodié, Judith |
| author_facet | González Segura, Àlex Prohens Coll, Llucia Julià, Laura Amoretti Guadall, Silvia RIbero Rodríguez, Maria Pino Camacho, Laura Cano Escalera, Guillermo Mané, Anna Rodriguez Jimenez, Roberto Roldán, Alexandra Sarró, Salvador Ibáñez Cuadrado, Ángela Usall i Rodié, Judith Lobo, Antonio García Rizo, Clemente Cuesta, Manuel J. Parellada, Mara González-Pinto, Ana Berrocoso, Esther Bernardo Arroyo, Miquel Mas Herrero, Sergi Rodríguez Ferret, Natalia |
| author_role | author |
| collection | Dipòsit Digital de la UB |
| description | Both genetic and environmental factors have been found to play a significant role in psychosis relapse, either independently or through their synergistic interaction. Recently, DNA methylation (DNAm) has been proposed through the calculation of methylation profile scores (MPS). The aim of the present study is to evaluate the association of MPS as a surrogate marker of the biological impact of early stressful life events (including stressful intrauterine conditions and obstetric complications, childhood adversity and toxic habits), with the risk of schizophrenia (SCZ) relapse. 91 participants from a cohort of first-episode schizophrenia (FES) patients with less than five years of evolution were classified as non-relapse (patients who had not experienced a relapse after 3 years of enrollment) or relapse (patients who relapsed during the 3-year follow-up). As inclusion criteria, patients fulfilled Andreasen’s criteria of symptomatic remission. Genome-wide DNA methylation (DNAm) was profiled and fourteen MPS reflecting environmental exposure were constructed including both early stressful life events (including stressful intrauterine conditions and delivery issues, childhood adversity) and toxic habits. Increased levels of MPS reflecting gestational diabetes (p = 0.009), hypertensive disorders during pregnancy (p = 0.004), pre-eclampsia (p = 0.049), early preterm birth (p = 0.030), childhood adversity abuse (p = 0.021) and all childhood adversity (p = 0.030) were significantly associated with an increased risk of relapse. Our study suggests that changes in specific methylation patterns may represent one of the biological mechanisms linking early stressful life events to an increased risk of relapse. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_cd5cec5581a16e079088728403592ae2 |
| institution | Universidad de Barcelona |
| instname_str | Universidad de Barcelona |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:diposit.ub.edu:2445/227759 |
| publishDate | 2025 |
| publishDateSort | 2025 |
| publisher | Elsevier B.V. |
| publisherStr | Elsevier B.V. |
| reponame_str | Dipòsit Digital de la UB |
| spelling | Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia. González Segura, Àlex Prohens Coll, Llucia Julià, Laura Amoretti Guadall, Silvia RIbero Rodríguez, Maria Pino Camacho, Laura Cano Escalera, Guillermo Mané, Anna Rodriguez Jimenez, Roberto Roldán, Alexandra Sarró, Salvador Ibáñez Cuadrado, Ángela Usall i Rodié, Judith Lobo, Antonio García Rizo, Clemente Cuesta, Manuel J. Parellada, Mara González-Pinto, Ana Berrocoso, Esther Bernardo Arroyo, Miquel Mas Herrero, Sergi Rodríguez Ferret, Natalia Esquizofrènia Metilació Epigenètica Schizophrenia Methylation Epigenetics Both genetic and environmental factors have been found to play a significant role in psychosis relapse, either independently or through their synergistic interaction. Recently, DNA methylation (DNAm) has been proposed through the calculation of methylation profile scores (MPS). The aim of the present study is to evaluate the association of MPS as a surrogate marker of the biological impact of early stressful life events (including stressful intrauterine conditions and obstetric complications, childhood adversity and toxic habits), with the risk of schizophrenia (SCZ) relapse. 91 participants from a cohort of first-episode schizophrenia (FES) patients with less than five years of evolution were classified as non-relapse (patients who had not experienced a relapse after 3 years of enrollment) or relapse (patients who relapsed during the 3-year follow-up). As inclusion criteria, patients fulfilled Andreasen’s criteria of symptomatic remission. Genome-wide DNA methylation (DNAm) was profiled and fourteen MPS reflecting environmental exposure were constructed including both early stressful life events (including stressful intrauterine conditions and delivery issues, childhood adversity) and toxic habits. Increased levels of MPS reflecting gestational diabetes (p = 0.009), hypertensive disorders during pregnancy (p = 0.004), pre-eclampsia (p = 0.049), early preterm birth (p = 0.030), childhood adversity abuse (p = 0.021) and all childhood adversity (p = 0.030) were significantly associated with an increased risk of relapse. Our study suggests that changes in specific methylation patterns may represent one of the biological mechanisms linking early stressful life events to an increased risk of relapse. Elsevier B.V. https://hdl.handle.net/2445/227759 |
| spellingShingle | Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia. González Segura, Àlex Esquizofrènia Metilació Epigenètica Schizophrenia Methylation Epigenetics |
| status_str | publishedVersion |
| title | Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia. |
| title_full | Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia. |
| title_fullStr | Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia. |
| title_full_unstemmed | Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia. |
| title_short | Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia. |
| title_sort | Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia. |
| topic | Esquizofrènia Metilació Epigenètica Schizophrenia Methylation Epigenetics |
| topic_facet | Esquizofrènia Metilació Epigenètica Schizophrenia Methylation Epigenetics |
| url | https://hdl.handle.net/2445/227759 |