Molecular population genetics of the Polycomb genes in Drosophila subobscura
Polycomb group (PcG) proteins are important regulatory factors that modulate the chromatin state. They form protein complexes that repress gene expression by the introduction of posttranslational histone modifications. The study of PcG proteins divergence in Drosophila revealed signals of coevolutio...
| Authors: | ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2017 |
| Country: | España |
| Institution: | Universidad de Barcelona |
| Repository: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/122640 |
| Online Access: | https://hdl.handle.net/2445/122640 |
| Access Level: | Open access |
| Keyword: | Drosòfila subobscura Mapatge cromosòmic humà Genètica molecular Drosophila subobscura Human gene mapping Molecular genetics |
| _version_ | 1878740082015338496 |
|---|---|
| author | Calvo Martín, Juan Manuel |
| author2 | Papaceit Vidal, Montserrat Segarra Robert, Carmen |
| author2_role | author author |
| author_browse | Calvo Martín, Juan Manuel Papaceit Vidal, Montserrat Segarra Robert, Carmen |
| author_facet | Calvo Martín, Juan Manuel Papaceit Vidal, Montserrat Segarra Robert, Carmen |
| author_role | author |
| collection | Dipòsit Digital de la UB |
| description | Polycomb group (PcG) proteins are important regulatory factors that modulate the chromatin state. They form protein complexes that repress gene expression by the introduction of posttranslational histone modifications. The study of PcG proteins divergence in Drosophila revealed signals of coevolution among them and an acceleration of the nonsynonymous evolutionary rate in the lineage ancestral to the obscura group species, mainly in subunits of the Pcl-PRC2 complex. Herein, we have studied the nucleotide polymorphism of PcG genes in a natural population of D. subobscura to detect whether natural selection has also modulated the evolution of these important regulatory genes in a more recent time scale. Results show that most genes are under the action of purifying selection and present a level and pattern of polymorphism consistent with predictions of the neutral model, the exceptions being Su(z)12 and Pho. MK tests indicate an accumulation of adaptive changes in the SU(Z)12 protein during the divergence of D. subobscura and D. guanche. In contrast, the HKA test shows a deficit of polymorphism at Pho. The most likely explanation for this reduced variation is the location of this gene in the dot-like chromosome and would indicate that this chromosome also has null or very low recombination in D. subobscura, as reported in D. melanogaster. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_cd2e7c2c217ed8f3fa5e95f648fbc4e4 |
| institution | Universidad de Barcelona |
| instname_str | Universidad de Barcelona |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:diposit.ub.edu:2445/122640 |
| publishDate | 2017 |
| publishDateSort | 2017 |
| publisher | Public Library of Science (PLoS) |
| publisherStr | Public Library of Science (PLoS) |
| reponame_str | Dipòsit Digital de la UB |
| spelling | Molecular population genetics of the Polycomb genes in Drosophila subobscura Calvo Martín, Juan Manuel Papaceit Vidal, Montserrat Segarra Robert, Carmen Drosòfila subobscura Mapatge cromosòmic humà Genètica molecular Drosophila subobscura Human gene mapping Molecular genetics Polycomb group (PcG) proteins are important regulatory factors that modulate the chromatin state. They form protein complexes that repress gene expression by the introduction of posttranslational histone modifications. The study of PcG proteins divergence in Drosophila revealed signals of coevolution among them and an acceleration of the nonsynonymous evolutionary rate in the lineage ancestral to the obscura group species, mainly in subunits of the Pcl-PRC2 complex. Herein, we have studied the nucleotide polymorphism of PcG genes in a natural population of D. subobscura to detect whether natural selection has also modulated the evolution of these important regulatory genes in a more recent time scale. Results show that most genes are under the action of purifying selection and present a level and pattern of polymorphism consistent with predictions of the neutral model, the exceptions being Su(z)12 and Pho. MK tests indicate an accumulation of adaptive changes in the SU(Z)12 protein during the divergence of D. subobscura and D. guanche. In contrast, the HKA test shows a deficit of polymorphism at Pho. The most likely explanation for this reduced variation is the location of this gene in the dot-like chromosome and would indicate that this chromosome also has null or very low recombination in D. subobscura, as reported in D. melanogaster. Public Library of Science (PLoS) https://hdl.handle.net/2445/122640 |
| spellingShingle | Molecular population genetics of the Polycomb genes in Drosophila subobscura Calvo Martín, Juan Manuel Drosòfila subobscura Mapatge cromosòmic humà Genètica molecular Drosophila subobscura Human gene mapping Molecular genetics |
| status_str | publishedVersion |
| title | Molecular population genetics of the Polycomb genes in Drosophila subobscura |
| title_full | Molecular population genetics of the Polycomb genes in Drosophila subobscura |
| title_fullStr | Molecular population genetics of the Polycomb genes in Drosophila subobscura |
| title_full_unstemmed | Molecular population genetics of the Polycomb genes in Drosophila subobscura |
| title_short | Molecular population genetics of the Polycomb genes in Drosophila subobscura |
| title_sort | Molecular population genetics of the Polycomb genes in Drosophila subobscura |
| topic | Drosòfila subobscura Mapatge cromosòmic humà Genètica molecular Drosophila subobscura Human gene mapping Molecular genetics |
| topic_facet | Drosòfila subobscura Mapatge cromosòmic humà Genètica molecular Drosophila subobscura Human gene mapping Molecular genetics |
| url | https://hdl.handle.net/2445/122640 |