Multivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell-Wall Hydrolysis

Dendritic cell-wall mimics: Choline-binding proteins from Streptococcus pneumoniae recognize distinctive multivalent choline architectures on the bacterial cell wall. Choline-functionalized dendrimers are potent inhibitors of these essential enzymes, with a 103–104-fold higher affinity than free cho...

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Authors: Hernandez-Rocamora, Victor; Maestro García-Donas, María Beatriz; de Waal, Bas; Morales, María; Garcia, Pedro; Meijer, Bert; Merx, Maarten; Sanz, Jesús
Format: Article
Publication date:2009
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/93420.2
Online Access:https://hdl.handle.net/20.500.14352/93420.2
Access Level:Open access
Keyword:577.1
Bioquímica (Química)
2403 Bioquímica
Summary:Dendritic cell-wall mimics: Choline-binding proteins from Streptococcus pneumoniae recognize distinctive multivalent choline architectures on the bacterial cell wall. Choline-functionalized dendrimers are potent inhibitors of these essential enzymes, with a 103–104-fold higher affinity than free choline, resulting in inhibition of autolysis and cell separation in bacterial cultures at low micromolar concentrations

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