Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
Introduction: Age-related health, brain, and cognitive impairment is a great challenge in current society. Cognitive training, aerobic exercise and their combination have been shown to benefit health, brain, cognition and psychological status in healthy older adults. Inconsistent results across stud...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2019 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/175688 |
| Online Access: | https://hdl.handle.net/2445/175688 |
| Access Level: | Open access |
| Keyword: | Persones grans Exercici Neurociència cognitiva Older people Exercise Cognitive neuroscience |
| _version_ | 1878739974413615104 |
|---|---|
| author | Castells Sánchez, Alba |
| author2 | Roig-Coll, Francesca Lamonja-Vicente, Noemí Altés Magret, Marina Torán Monserrat, Pere Via i García, Marc García Molina, Alberto Tormos, José María Heras, Antonio Alzamora, María Teresa Forés, Rosa Pera, Guillem Dacosta-Aguayo, Rosalia Soriano Raya, Juan José Cáceres, Cynthia Montero Alía, Pilar Montero Alia, Juan José Jiménez González, María Mercedes Hernández Pérez, María Perera Lluna, Alexandre Grove, George A. Munuera, Josep Domènech, Sira Erickson, Kirk I. Mataró Serrat, Maria |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Altés Magret, Marina Alzamora, María Teresa Castells Sánchez, Alba Cáceres, Cynthia Dacosta-Aguayo, Rosalia Domènech, Sira Erickson, Kirk I. Forés, Rosa García Molina, Alberto Grove, George A. Heras, Antonio Hernández Pérez, María Jiménez González, María Mercedes Lamonja-Vicente, Noemí Mataró Serrat, Maria Montero Alia, Juan José Montero Alía, Pilar Munuera, Josep Pera, Guillem Perera Lluna, Alexandre Roig-Coll, Francesca Soriano Raya, Juan José Tormos, José María Torán Monserrat, Pere Via i García, Marc |
| author_facet | Castells Sánchez, Alba Roig-Coll, Francesca Lamonja-Vicente, Noemí Altés Magret, Marina Torán Monserrat, Pere Via i García, Marc García Molina, Alberto Tormos, José María Heras, Antonio Alzamora, María Teresa Forés, Rosa Pera, Guillem Dacosta-Aguayo, Rosalia Soriano Raya, Juan José Cáceres, Cynthia Montero Alía, Pilar Montero Alia, Juan José Jiménez González, María Mercedes Hernández Pérez, María Perera Lluna, Alexandre Grove, George A. Munuera, Josep Domènech, Sira Erickson, Kirk I. Mataró Serrat, Maria |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Introduction: Age-related health, brain, and cognitive impairment is a great challenge in current society. Cognitive training, aerobic exercise and their combination have been shown to benefit health, brain, cognition and psychological status in healthy older adults. Inconsistent results across studies may be related to several variables. We need to better identify cognitive changes, individual variables that may predict the effect of these interventions, and changes in structural and functional brain outcomes as well as physiological molecular correlates that may be mediating these effects. Projecte Moviment is a multi-domain randomized trial examining the effect of these interventions applied 5 days per week for 3 months compared to a passive control group. The aim of this paper is to describe the sample, procedures and planned analyses. Methods: One hundred and forty healthy physically inactive older adults will be randomly assigned to computerized cognitive training (CCT), aerobic exercise (AE), combined training (COMB), or a control group. The intervention consists of a 3 month home-based program 5 days per week in sessions of 45 min. Data from cognitive, physical, and psychological tests, cardiovascular risk factors, structural and functional brain scans, and blood samples will be obtained before and after the intervention. Results: Effects of the interventions on cognitive outcomes will be described in intention-to-treat and per protocol analyses. We will also analyze potential genetic, demographic, brain, and physiological molecular correlates that may predict the effects of intervention, as well as the association between cognitive effects and changes in these variables using the per protocol sample. Discussion: Projecte Moviment is a multi-domain intervention trial based on prior evidence that aims to understand the effects of CCT, AE, and COMB on cognitive and psychological outcomes compared to a passive control group, and to determine related biological correlates and predictors of the intervention effects.Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03123900. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_cb67eae9a47d3ec60c95526e4e4dfffa |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/175688 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | Frontiers Media |
| publisherStr | Frontiers Media |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol Castells Sánchez, Alba Roig-Coll, Francesca Lamonja-Vicente, Noemí Altés Magret, Marina Torán Monserrat, Pere Via i García, Marc García Molina, Alberto Tormos, José María Heras, Antonio Alzamora, María Teresa Forés, Rosa Pera, Guillem Dacosta-Aguayo, Rosalia Soriano Raya, Juan José Cáceres, Cynthia Montero Alía, Pilar Montero Alia, Juan José Jiménez González, María Mercedes Hernández Pérez, María Perera Lluna, Alexandre Grove, George A. Munuera, Josep Domènech, Sira Erickson, Kirk I. Mataró Serrat, Maria Persones grans Exercici Neurociència cognitiva Older people Exercise Cognitive neuroscience Introduction: Age-related health, brain, and cognitive impairment is a great challenge in current society. Cognitive training, aerobic exercise and their combination have been shown to benefit health, brain, cognition and psychological status in healthy older adults. Inconsistent results across studies may be related to several variables. We need to better identify cognitive changes, individual variables that may predict the effect of these interventions, and changes in structural and functional brain outcomes as well as physiological molecular correlates that may be mediating these effects. Projecte Moviment is a multi-domain randomized trial examining the effect of these interventions applied 5 days per week for 3 months compared to a passive control group. The aim of this paper is to describe the sample, procedures and planned analyses. Methods: One hundred and forty healthy physically inactive older adults will be randomly assigned to computerized cognitive training (CCT), aerobic exercise (AE), combined training (COMB), or a control group. The intervention consists of a 3 month home-based program 5 days per week in sessions of 45 min. Data from cognitive, physical, and psychological tests, cardiovascular risk factors, structural and functional brain scans, and blood samples will be obtained before and after the intervention. Results: Effects of the interventions on cognitive outcomes will be described in intention-to-treat and per protocol analyses. We will also analyze potential genetic, demographic, brain, and physiological molecular correlates that may predict the effects of intervention, as well as the association between cognitive effects and changes in these variables using the per protocol sample. Discussion: Projecte Moviment is a multi-domain intervention trial based on prior evidence that aims to understand the effects of CCT, AE, and COMB on cognitive and psychological outcomes compared to a passive control group, and to determine related biological correlates and predictors of the intervention effects.Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03123900. Frontiers Media https://hdl.handle.net/2445/175688 |
| spellingShingle | Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol Castells Sánchez, Alba Persones grans Exercici Neurociència cognitiva Older people Exercise Cognitive neuroscience |
| status_str | publishedVersion |
| title | Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol |
| title_full | Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol |
| title_fullStr | Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol |
| title_full_unstemmed | Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol |
| title_short | Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol |
| title_sort | Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol |
| topic | Persones grans Exercici Neurociència cognitiva Older people Exercise Cognitive neuroscience |
| topic_facet | Persones grans Exercici Neurociència cognitiva Older people Exercise Cognitive neuroscience |
| url | https://hdl.handle.net/2445/175688 |