The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development
In female mammals, the two X chromosomes are subject to epigenetic gene regulation in order to balance X-linked gene dosage with autosomes and in relation to males, which have one X and one Y chromosome. This is achieved by an intricate interplay of several processes; X-chromosome inactivation and r...
| Authors: | ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2023 |
| Country: | España |
| Institution: | Universitat Pompeu Fabra |
| Repository: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/57322 |
| Online Access: | http://hdl.handle.net/10230/57322 http://dx.doi.org/10.1042/BCJ20220450 |
| Access Level: | Open access |
| Keyword: | X chromosome Dosage compensation Epigenetic reprogramming Germ cell development |
| _version_ | 1878739899653292033 |
|---|---|
| author | Mattimoe, Tom |
| author2 | Payer, Bernhard |
| author2_role | author |
| author_browse | Mattimoe, Tom Payer, Bernhard |
| author_facet | Mattimoe, Tom Payer, Bernhard |
| author_role | author |
| collection | Repositorio Digital de la UPF |
| description | In female mammals, the two X chromosomes are subject to epigenetic gene regulation in order to balance X-linked gene dosage with autosomes and in relation to males, which have one X and one Y chromosome. This is achieved by an intricate interplay of several processes; X-chromosome inactivation and reactivation elicit global epigenetic regulation of expression from one X chromosome in a stage-specific manner, whilst the process of X-chromosome upregulation responds to this by fine-tuning transcription levels of the second X. The germline is unique in its function of transmitting both the genetic and epigenetic information from one generation to the next, and remodelling of the X chromosome is one of the key steps in setting the stage for successful development. Here, we provide an overview of the complex dynamics of X-chromosome dosage control during embryonic and germ cell development, and aim to decipher its potential role for normal germline competency. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_ca0cd7df20d8d7fe5173f37b2b5ccd9d |
| institution | Universitat Pompeu Fabra |
| instname_str | Universitat Pompeu Fabra |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositori.upf.edu:10230/57322 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher | Portland Press |
| publisherStr | Portland Press |
| reponame_str | Repositorio Digital de la UPF |
| spelling | The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development Mattimoe, Tom Payer, Bernhard X chromosome Dosage compensation Epigenetic reprogramming Germ cell development In female mammals, the two X chromosomes are subject to epigenetic gene regulation in order to balance X-linked gene dosage with autosomes and in relation to males, which have one X and one Y chromosome. This is achieved by an intricate interplay of several processes; X-chromosome inactivation and reactivation elicit global epigenetic regulation of expression from one X chromosome in a stage-specific manner, whilst the process of X-chromosome upregulation responds to this by fine-tuning transcription levels of the second X. The germline is unique in its function of transmitting both the genetic and epigenetic information from one generation to the next, and remodelling of the X chromosome is one of the key steps in setting the stage for successful development. Here, we provide an overview of the complex dynamics of X-chromosome dosage control during embryonic and germ cell development, and aim to decipher its potential role for normal germline competency. Portland Press http://hdl.handle.net/10230/57322 http://dx.doi.org/10.1042/BCJ20220450 |
| spellingShingle | The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development Mattimoe, Tom X chromosome Dosage compensation Epigenetic reprogramming Germ cell development |
| status_str | publishedVersion |
| title | The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development |
| title_full | The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development |
| title_fullStr | The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development |
| title_full_unstemmed | The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development |
| title_short | The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development |
| title_sort | The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development |
| topic | X chromosome Dosage compensation Epigenetic reprogramming Germ cell development |
| topic_facet | X chromosome Dosage compensation Epigenetic reprogramming Germ cell development |
| url | http://hdl.handle.net/10230/57322 http://dx.doi.org/10.1042/BCJ20220450 |